1K3B
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE I (CATHEPSIN C): EXCLUSION DOMAIN ADDED TO AN ENDOPEPTIDASE FRAMEWORK CREATES THE MACHINE FOR ACTIVATION OF GRANULAR SERINE PROTEASES
Descriptor:dipeptydil-peptidase I exclusion domain, dipeptydil-peptidase I light chain, dipeptydil-peptidase I heavy chain, ...
Authors:Turk, D., Janjic, V., Stern, I., Podobnik, M., Lamba, D., Dahl, S.W., Lauritzen, C., Pedersen, J., Turk, V., Turk, B.
Deposit date:2001-10-02
Release date:2002-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.
EMBO J., 20, 2001
1JQP
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DIPEPTIDYL PEPTIDASE I (CATHEPSIN C), A TETRAMERIC CYSTEINE PROTEASE OF THE PAPAIN FAMILY
Descriptor:dipeptidyl peptidase I, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Olsen, J.G., Kadziola, A., Lauritzen, C., Pedersen, J., Larsen, S., Dahl, S.W.
Deposit date:2001-08-08
Release date:2002-10-18
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain
FEBS LETT., 506, 2001
2DJF
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE I (CATHEPSIN C) IN COMPLEX WITH THE INHIBITOR GLY-PHE-CHN2
Descriptor:Dipeptidyl-peptidase 1, N-ACETYL-D-GLUCOSAMINE, ACETIC ACID, ...
Authors:Molgaard, A., Arnau, J., Lauritzen, C., Larsen, S., Petersen, G., Pedersen, J.
Deposit date:2006-04-02
Release date:2006-11-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2
Biochem.J., 401, 2007
2DJG
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RE-DETERMINATION OF THE NATIVE STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE I (CATHEPSIN C)
Descriptor:Dipeptidyl-peptidase 1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Molgaard, A., Arnau, J., Lauritzen, C., Larsen, S., Petersen, G., Pedersen, J.
Deposit date:2006-04-02
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2
Biochem.J., 401, 2007
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DISCOVERY OF NOVEL CYANAMIDE-BASED INHIBITORS OF CATHEPSIN C
Descriptor:Dipeptidyl peptidase 1, 2,5-dibromo-N-{(3R,5S)-1-[(Z)-iminomethyl]-5-methylpyrrolidin-3-yl}benzenesulfonamide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhao, B., Laine, D.
Deposit date:2010-10-22
Release date:2011-10-26
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C
To be Published
4CDC
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HUMAN DPP1 IN COMPLEX WITH (2S)-2-AMINO-N-((1S)-1-CYANO-2-(4- PHENYLPHENYL)ETHYL)BUTANAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDD
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HUMAN DPP1 IN COMPLEX WITH (2S)-N-((1S)-1-CYANO-2-(4-(4-CYANOPHENYL) PHENYL)ETHYL)PIPERIDINE-2-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDE
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HUMAN DPP1 IN COMPLEX WITH 4-AMINO-N-((1S)-1-CYANO-2-(4-(4- CYANOPHENYL)PHENYL)ETHYL)TETRAHYDROPYRAN-4-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4CDF
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HUMAN DPP1 IN COMPLEX WITH (2S,4S)-N-((1S)-1-CYANO-2-(4-(4- CYANOPHENYL)PHENYL)ETHYL)-4-HYDROXY-PIPERIDINE-2-CARBOXAMIDE
Descriptor:DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ...
Authors:Debreczeni, J., Edman, K., Furber, M., Tiden, A., Gardiner, P., Mete, T., Ford, R., Millichip, I., Stein, L., Mather, A., Kinchin, E., Luckhurst, C., Cage, P., Sanghanee, H., Breed, J., Wissler, L.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57, 2014
4OEL
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CRYSTAL STRUCTURE OF CATHEPSIN C IN COMPLEX WITH DIPEPTIDE SUBSTRATES
Descriptor:Dipeptidyl peptidase 1 Heavy chain, Dipeptidyl peptidase 1 Light chain, SERINE, ...
Authors:Zhao, B., Smallwood, A., Concha, N.
Deposit date:2014-01-13
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
Biochemistry, 51, 2012
4OEM
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CRYSTAL STRUCTURE OF CATHEPSIN C IN COMPLEX WITH DIPEPTIDE SUBSTRATES
Descriptor:Dipeptidyl peptidase 1 Heavy chain, Dipeptidyl peptidase 1 Light chain, GLYCINE, ...
Authors:Zhao, B., Smallwood, A., Concha, N.
Deposit date:2014-01-13
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.
Biochemistry, 51, 2012
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