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7S47
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BU of 7s47 by Molmil
Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E)
Descriptor: Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
2BRQ
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Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
Descriptor: FILAMIN A, GLUTATHIONE, GLYCEROL, ...
Authors:Kiema, T.-R, Ylanne, J.
Deposit date:2005-05-11
Release date:2006-02-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis of Filamin Binding to Integrins and Competition with Talin.
Mol.Cell, 21, 2006
3G9W
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Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ...
Authors:Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
2JF1
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CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE
Descriptor: FILAMIN-A, GLYCEROL, INTEGRIN BETA-2 SUBUNIT
Authors:Kiema, T, Ylanne, J.
Deposit date:2007-01-25
Release date:2008-02-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding.
Blood, 112, 2008
6VGU
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BU of 6vgu by Molmil
Crystal structure of FERM-folded talin head domain bound to the NPLY motif of beta3-integrin
Descriptor: Integrin beta-3,Talin-1
Authors:Zhang, P, Sun, Y, Wu, J.
Deposit date:2020-01-09
Release date:2020-12-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding.
Proc.Natl.Acad.Sci.USA, 117, 2020
4UM8
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Crystal structure of alpha V beta 6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
8GCD
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Full length Integrin AlphaIIbBeta3 in inactive state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Full-length AlphaIIbBeta3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture
To Be Published
8T2U
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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
7NWL
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Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-17
Release date:2021-06-02
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
8GCE
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The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Full-length AlphaIIbBeta3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture
To Be Published
7LA4
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Integrin AlphaIIbBeta3-PT25-2 Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J.
Deposit date:2021-01-05
Release date:2022-01-12
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
Blood Adv, 5, 2021
8T2V
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BU of 8t2v by Molmil
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A.
Deposit date:2023-06-06
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
7NXD
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BU of 7nxd by Molmil
Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-18
Release date:2021-08-25
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
2LJE
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BU of 2lje by Molmil
Biphosphorylated (747pY, 759pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions
Descriptor: Integrin beta-3
Authors:Deshmukh, L, Vinogradova, O.
Deposit date:2011-09-11
Release date:2011-10-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Tyrosine phosphorylation as a conformational switch: a case study of integrin Beta3 cytoplasmic tail.
J.Biol.Chem., 286, 2011
2L1C
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BU of 2l1c by Molmil
Shc-PTB:biphosphorylated integrin beta3 cytoplasmic tail complex (1:1)
Descriptor: Integrin beta-3, SHC (Src homology 2 domain containing) transforming protein 1, isoform CRA_d
Authors:Deshmukh, L, Gorbatyuk, V, Vinogradova, O.
Deposit date:2010-07-27
Release date:2010-08-18
Last modified:2012-04-18
Method:SOLUTION NMR
Cite:Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
J.Biol.Chem., 285, 2010
2LJD
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BU of 2ljd by Molmil
monophosphorylated (747pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions
Descriptor: Integrin beta-3
Authors:Deshmukh, L, Vinogradova, O.
Deposit date:2011-09-11
Release date:2011-10-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Tyrosine phosphorylation as a conformational switch: a case study of integrin Beta3 cytoplasmic tail.
J.Biol.Chem., 286, 2011
2MTP
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BU of 2mtp by Molmil
The structure of Filamin repeat 21 bound to integrin
Descriptor: Filamin-A, Integrin alpha-IIb, Integrin beta-3
Authors:Liu, J, Qin, J.
Deposit date:2014-08-28
Release date:2015-04-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural mechanism of integrin inactivation by filamin.
Nat.Struct.Mol.Biol., 22, 2015
5ZAZ
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BU of 5zaz by Molmil
Solution structure of integrin b2 monomer tranmembrane domain in bicelle
Descriptor: Integrin beta-2
Authors:Li, H, Guo, J, Xu, C.
Deposit date:2018-02-09
Release date:2018-10-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Intramembrane ionic protein-lipid interaction regulates integrin structure and function.
PLoS Biol., 16, 2018
1KUZ
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BU of 1kuz by Molmil
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Descriptor: integrin alpha-IIb, integrin beta-3
Authors:Weljie, A.M, Hwang, P.M, Vogel, H.J.
Deposit date:2002-01-22
Release date:2002-05-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc.Natl.Acad.Sci.USA, 99, 2002
1KUP
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BU of 1kup by Molmil
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Descriptor: integrin alpha-IIb, integrin beta-3
Authors:Weljie, A.M, Hwang, P.M, Vogel, H.J.
Deposit date:2002-01-22
Release date:2002-05-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc.Natl.Acad.Sci.USA, 99, 2002
1S4X
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BU of 1s4x by Molmil
NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles
Descriptor: Integrin beta-3
Authors:Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J.
Deposit date:2004-01-19
Release date:2004-03-09
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Proc.Natl.Acad.Sci.USA, 101, 2004
1M8O
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BU of 1m8o by Molmil
Platelet integrin alfaIIb-beta3 cytoplasmic domain
Descriptor: platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain
Authors:Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J.
Deposit date:2002-07-25
Release date:2002-09-18
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A Structural mechanism of integrin alfaiib beta3 "Inside-out" Activation as regulated by its cytoplasmic face.
Cell(Cambridge,Mass.), 110, 2002
2KNC
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BU of 2knc by Molmil
Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex
Descriptor: Integrin alpha-IIb, Integrin beta-3
Authors:Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J.
Deposit date:2009-08-20
Release date:2009-09-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation.
Proc.Natl.Acad.Sci.USA, 106, 2009
2KV9
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Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain
Descriptor: Integrin beta-3
Authors:Metcalf, D.G, Kielec, J.M, Valentine, K.G, Wand, A, Bennett, J.S, William, D.F, Moore, D.T, Molnar, K.
Deposit date:2010-03-10
Release date:2011-01-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR analysis of the {alpha}IIb{beta}3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2LJF
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Monophosphorylated (747pY) beta3 integrin cytoplasmic tail under aqueous conditions
Descriptor: Integrin beta-3
Authors:Deshmukh, L, Vinogradova, O.
Deposit date:2011-09-11
Release date:2011-10-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Tyrosine phosphorylation as a conformational switch: a case study of integrin Beta3 cytoplasmic tail.
J.Biol.Chem., 286, 2011

217705

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