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1EBL
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THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL-ACP SYNTHASE III, COENZYME A
Authors:Davies, C, Heath, R.J, White, S.W, Rock, C.O.
Deposit date:2000-01-24
Release date:2000-02-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
1HN9
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III
Descriptor: BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, PHOSPHATE ION
Authors:Qiu, X, Janson, C.A, Konstantinidis, A.K, Nwagwu, S, Silverman, C, Smith, W.W, Khandekar, S.K, Lonsdale, J, Abdel-Meguid, S.S.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.
J.Biol.Chem., 274, 1999
1HND
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III-COA COMPLEX
Descriptor: BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, COENZYME A
Authors:Qiu, X, Janson, C.A, Smith, W.W, Head, M, Lonsdale, J, Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNH
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + DEGRADED FORM OF ACETYL-COA
Descriptor: BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, COENZYME A
Authors:Qiu, X, Janson, C.A, Smith, W.W, Head, M, Lonsdale, J, Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNJ
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III + MALONYL-COA
Descriptor: BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III, MALONYL-COENZYME A, PHOSPHATE ION
Authors:Qiu, X, Janson, C.A, Smith, W.W, Head, M, Lonsdale, J, Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HNK
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III, APO TETRAGONAL FORM
Descriptor: BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III
Authors:Qiu, X, Janson, C.A, Smith, W.W, Head, M, Lonsdale, J, Konstantinidis, A.K.
Deposit date:2000-12-07
Release date:2000-12-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of beta-ketoacyl-acyl carrier protein synthase III.
J.Mol.Biol., 307, 2001
1HZP
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Crystal Structure of the Myobacterium Tuberculosis Beta-Ketoacyl-Acyl Carrier Protein Synthase III
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III, GLYCEROL, LAURIC ACID
Authors:Scarsdale, J.N, Kazanina, G, He, X, Reynolds, K.A, Wright, H.T, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-25
Release date:2001-06-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
J.Biol.Chem., 276, 2001
1M1M
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X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
Authors:Sacchettini, J.C, Sridharan, S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-06-19
Release date:2002-07-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
1MZJ
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Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
Descriptor: ACETYL GROUP, Beta-ketoacylsynthase III, COENZYME A
Authors:Pan, H, Tsai, S.C, Meadows, E.S, Miercke, L.J.W, Keatinge-Clay, A, O'Connell, J, Khosla, C, Stroud, R.M.
Deposit date:2002-10-08
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
1MZS
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CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor
Descriptor: 1-(5-CARBOXYPENTYL)-5-(2,6-DICHLOROBENZYLOXY)-1H-INDOLE-2-CARBOXYLIC ACID, 3-oxoacyl-[acyl-carrier-protein] synthase III, PHOSPHATE ION
Authors:Daines, R.A, Pendrak, I, Sham, K, Van Aller, G.S, Konstantinidis, A.K, Lonsdale, J.T, Janson, C.A, Qui, X, Brandt, M, Silverman, C, Head, M.S.
Deposit date:2002-10-09
Release date:2002-11-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling
J.Med.Chem., 46, 2003
1U6E
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1.85 Angstrom Crystal Structure of the C112A Mutant of Mycobacterium Tuberculosis Beta-Ketoacyl-Acyl Carrier Protein Synthase III (FabH)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III, CHLORIDE ION
Authors:Mussayev, F, Sachedeva, S, Scarsdale, J.N, Reynolds, K.A, Wright, H.T.
Deposit date:2004-07-29
Release date:2005-05-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
J.Mol.Biol., 346, 2005
1U6S
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Crystal Structure of the Complex Between Mycobacterium Tuberculosis Beta-Ketoacyl-Acyl Carrier Protein Synthase III and Lauroyl Coenzyme A
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III, DODECYL-COA
Authors:Musayev, F, Sachdeva, S, Scarsdale, J.N, Reynolds, K.A, Wright, H.T.
Deposit date:2004-07-30
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A.
J.Mol.Biol., 346, 2005
1UB7
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The Crystal Analysis of Beta-Keroacyl-[Acyl Carrier Protein] Synthase III (FABH)From Thermus Thermophilus.
Descriptor: 3-oxoacyl-[acyl-carrier protein] synthase, GLYCEROL
Authors:Inagaki, E, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-03-31
Release date:2003-04-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase III (Fabh) from Thermus Thermophilus
To be Published
1ZOW
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Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase III
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III
Authors:Qiu, X, Choudhry, A.E, Janson, C.A, Grooms, M, Daines, R.A, Lonsdale, J.T, Khandekar, S.S.
Deposit date:2005-05-15
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.
Protein Sci., 14, 2005
2AHB
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X-ray crystal structure of R46A,R161A mutant of Mycobacterium tuberculosis FabH
Descriptor: Beta- ketoacyl-ACP synthase III
Authors:Brown, A.K, Sridharan, S, Kremer, L, Lindenberg, S, Dover, L.G, Sacchettini, J.C, Besra, G.S.
Deposit date:2005-07-27
Release date:2005-08-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis {beta}-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: FACTORS INFLUENCING CATALYSIS AND SUBSTRATE SPECIFICITY
J.Biol.Chem., 280, 2005
2AJ9
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X-ray crystal structure of W42A,R161A double mutant of Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III
Authors:Brown, A.K, Sridharan, S, Kremer, L, Lindenberg, S, Dover, L.G, Sacchettini, J.C, Besra, G.S.
Deposit date:2005-08-01
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: Factors Influencing Catalysis And Substrate Specificity.
J.Biol.Chem., 280, 2005
2EBD
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Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Aquifex aeolicus VF5
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3
Authors:Kumarevel, T.S, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-02-08
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Aquifex aeolicus VF5
To be Published
2EFT
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Methanethiol-CYS 112 inhibition complex of E. coli ketoacyl synthase III (FABH) and Coenzyme A (high concentration (1.7mM) soak)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, COENZYME A, METHANETHIOL, ...
Authors:Alhamadsheh, M.M, Musayev, F, Komissarov, A.A, Sachdeva, S, Wright, H.T, Scarsdale, N, Florova, G, Reynolds, K.A.
Deposit date:2007-02-24
Release date:2007-06-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes
Chem.Biol., 14, 2007
2GYO
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Methanethiol-Cys 112 Inhibition Complex of E. Coli Ketoacyl Synthase III (FabH) and Coenzyme A
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, COENZYME A, METHANETHIOL, ...
Authors:Alhamadsheh, M.M, Musayev, F, Komissarov, A.A, Sachdeva, S, Wright, H.T, Scarsdale, N, Florova, G, Reynolds, K.A.
Deposit date:2006-05-09
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes.
Chem.Biol., 14, 2007
2QNX
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Crystal structure of the complex between the mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and 11-[(decyloxycarbonyl)dithio]-undecanoic acid
Descriptor: 11-MERCAPTOUNDECANOIC ACID, 3-oxoacyl-[acyl-carrier-protein] synthase 3, O-DECYL HYDROGEN THIOCARBONATE
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QNY
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Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, BETA-MERCAPTOETHANOL, DECYL FORMATE
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QNZ
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Crystal structure of the complex between the mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl)-O-decyl ester carbono(dithioperoxoic) acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, BETA-MERCAPTOETHANOL, DECYL FORMATE
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QO0
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Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and 11-(decyldithiocarbonyloxy)-undecanoic acid
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, DECANE-1-THIOL
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QO1
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2.6 Angstrom Crystal Structure of the Complex Between 11-(decyldithiocarbonyloxy)-undecanoic acid and Mycobacterium Tuberculosis FabH.
Descriptor: 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID, 3-oxoacyl-[acyl-carrier-protein] synthase 3, DECANE-1-THIOL
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-07-19
Release date:2008-05-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15, 2008
2QX1
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Crystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide
Descriptor: Beta-ketoacyl-ACP synthase III, COENZYME A, DECANE-1-THIOL
Authors:Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A.
Deposit date:2007-08-10
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Bioorg.Chem., 36, 2008

217705

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