PDB: 30 resultsInfo pagesStatus searchChemie searchBIRD

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3SQZ	Crystal structure of HMG_CoA synthase complexed with CoA Descriptor: COENZYME A, GLYCEROL, Putative hydroxymethylglutaryl-CoA synthase Authors: Liu, Y.H, Fu, T.M, Liu, X, Su, X.D. Deposit date: 2011-07-06 Release date: 2012-07-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of HMG-CoA synthase from Streptococcus mutans To be Published
5HWO	MvaS in complex with 3-hydroxy-3-methylglutaryl coenzyme A Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ... Authors: Bock, T, Kasten, J, Blankenfeldt, W. Deposit date: 2016-01-29 Release date: 2016-05-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus. Chembiochem, 17, 2016
5HWQ	MvaS in complex with acetoacetyl coenzyme A Descriptor: ACETOACETYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ... Authors: Bock, T, Kasten, J, Blankenfeldt, W. Deposit date: 2016-01-29 Release date: 2016-05-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus. Chembiochem, 17, 2016
5HWR	MvaS in complex with coenzyme A Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ... Authors: Bock, T, Kasten, J, Blankenfeldt, W. Deposit date: 2016-01-29 Release date: 2016-05-11 Last modified: 2016-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus. Chembiochem, 17, 2016
3V4N	The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HMG-CoA synthase Authors: Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M. Deposit date: 2011-12-15 Release date: 2012-04-25 Last modified: 2014-09-10 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry, 51, 2012
5KP7	Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Holo Donor-ACP Descriptor: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ... Authors: Maloney, F.P, Smith, J.L. Deposit date: 2016-07-02 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc.Natl.Acad.Sci.USA, 113, 2016
1XPM	Crystal Structure of Staphylococcus aureus HMG-COA Synthase with HMG-CoA and Acetoacetyl-COA and Acetylated Cysteine Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, ... Authors: Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T. Deposit date: 2004-10-08 Release date: 2004-11-02 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time" Proc.Natl.Acad.Sci.USA, 47, 2004
2WYA	CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2) Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, HYDROXYMETHYLGLUTARYL-COA SYNTHASE, ... Authors: Yue, W.W, Shafqat, N, Savitsky, P, Roos, A.K, Cooper, C, Murray, J.W, von Delft, F, Arrowsmith, C, Wikstrom, M, Edwards, A, Bountra, C, Oppermann, U. Deposit date: 2009-11-13 Release date: 2009-11-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design. J.Mol.Biol., 398, 2010
3LEH	The Crystal Structure of smu.943c from Streptococcus mutans UA159 Descriptor: NITRATE ION, Putative hydroxymethylglutaryl-CoA synthase Authors: Su, X.-D, Liu, Y.H, Liu, X. Deposit date: 2010-01-14 Release date: 2011-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Crystal Structure of smu.943c from Streptococcus mutans UA159 TO BE PUBLISHED
5KP8	Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Acetyl Donor-ACP Descriptor: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ... Authors: Maloney, F.P, Smith, J.L. Deposit date: 2016-07-02 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc.Natl.Acad.Sci.USA, 113, 2016
1YSL	Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand. Descriptor: ACETOACETIC ACID, COENZYME A, GLYCEROL, ... Authors: Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. Deposit date: 2005-02-08 Release date: 2005-11-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA. Biochemistry, 44, 2005
3V4X	The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin Descriptor: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, HMG-CoA synthase Authors: Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M. Deposit date: 2011-12-15 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.952 Å) Cite: Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry, 51, 2012
2P8U	Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ... Authors: Turnbull, A, Shafqat, N, Salah, E, Niesen, F.H, Burgess, N, Bunkoczi, G, Debreczeni, J, Pike, A.C.W, Umeano, C, Gorrec, F, von Delft, F, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2007-03-23 Release date: 2007-04-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design. J.Mol.Biol., 398, 2010
1XPL	Crystal Structure of Staphylococcus aureus HMG-COA Synthase with Acetoacetyl-COA and Acetylated Cysteine Descriptor: 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, SULFATE ION Authors: Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T. Deposit date: 2004-10-08 Release date: 2004-11-02 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time" Proc.Natl.Acad.Sci.USA, 47, 2004
1XPK	CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-CoA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, ... Authors: Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T. Deposit date: 2004-10-08 Release date: 2004-11-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time" Proc.Natl.Acad.Sci.USA, 47, 2004
1TVZ	Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Staphylococcus aureus Descriptor: 3-hydroxy-3-methylglutaryl-CoA synthase, SULFATE ION Authors: Campobasso, N, Patel, M, Wilding, I.E, Kallender, H, Rosenberg, M, Gwynn, M. Deposit date: 2004-06-30 Release date: 2004-08-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism J.Biol.Chem., 279, 2004
5KP6	Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Apo Donor-ACP Descriptor: CurB, CurD Authors: Maloney, F.P, Smith, J.L. Deposit date: 2016-07-02 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc.Natl.Acad.Sci.USA, 113, 2016
4YXT	PksG, a HMG-CoA Synthase from Bacillus subtilus Descriptor: Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG Authors: Till, M, Nair, A.V, Robson, A, Race, P.R. Deposit date: 2015-03-23 Release date: 2016-06-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: PksG, a HMG-CoA Synthase from Bacillus subtilus To Be Published
5KP5	Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase Descriptor: CurD, SULFATE ION Authors: Maloney, F.P, Smith, J.L. Deposit date: 2016-07-02 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc.Natl.Acad.Sci.USA, 113, 2016
2F82	HMG-CoA synthase from Brassica juncea in the apo-form Descriptor: HMG-CoA synthase Authors: Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P. Deposit date: 2005-12-01 Release date: 2006-07-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proc.Natl.Acad.Sci.Usa, 103, 2006
5HWP	MvaS with acetylated Cys115 in complex with coenzyme A Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ... Authors: Bock, T, Kasten, J, Blankenfeldt, W. Deposit date: 2016-01-29 Release date: 2016-05-11 Last modified: 2016-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus. Chembiochem, 17, 2016
2HDB	HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HMG-CoA synthase, SULFATE ION Authors: Steussy, C.N, Sutherlin, A, Stauffacher, C.V. Deposit date: 2006-06-20 Release date: 2007-03-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A structural limitation on enzyme activity: the case of HMG-CoA synthase. Biochemistry, 45, 2006
1X9E	Crystal structure of HMG-CoA synthase from Enterococcus faecalis Descriptor: HMG-CoA synthase, SULFATE ION Authors: Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V. Deposit date: 2004-08-20 Release date: 2005-11-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA Biochemistry, 44, 2005
4YXQ	PksG, a HMG-CoA Synthase from Bacillus subtilis Descriptor: DI(HYDROXYETHYL)ETHER, Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG Authors: Nair, A.V, Race, P.R, Till, M. Deposit date: 2015-03-23 Release date: 2016-06-29 Method: X-RAY DIFFRACTION (2.47 Å) Cite: PksG, a HMG-CoA Synthase from Bacillus subtilis To Be Published
2FA0	HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, HMG-CoA synthase Authors: Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P. Deposit date: 2005-12-06 Release date: 2006-07-25 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proc.Natl.Acad.Sci.Usa, 103, 2006

 

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