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3VKG
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BU of 3vkg by Molmil
X-ray structure of an MTBD truncation mutant of dynein motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Dynein heavy chain, cytoplasmic, ...
Authors:Kon, T, Oyama, T, Shimo-Kon, R, Suto, K, Kurisu, G.
Deposit date:2011-11-16
Release date:2012-03-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:The 2.8 A crystal structure of the dynein motor domain
Nature, 484, 2012
8FD6
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BU of 8fd6 by Molmil
Engineered human dynein motor domain in the microtubule-unbound state in the buffer containing ATP-Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ...
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-02
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8GLV
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BU of 8glv by Molmil
96-nm repeat unit of doublet microtubules from Chlamydomonas reinhardtii flagella
Descriptor: 28 kDa inner dynein arm light chain, axonemal, AAA+ ATPase domain-containing protein, ...
Authors:Walton, T, Brown, A.
Deposit date:2023-03-23
Release date:2023-05-31
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Axonemal structures reveal mechanoregulatory and disease mechanisms.
Nature, 618, 2023
7MGM
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BU of 7mgm by Molmil
Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lahiri, I, Reimer, J.M, Leschziner, A.E.
Deposit date:2021-04-12
Release date:2022-01-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Elife, 11, 2022
8FDT
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BU of 8fdt by Molmil
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ...
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-04
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
7KZO
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BU of 7kzo by Molmil
Outer dynein arm docking complex bound to doublet microtubules from C. reinhardtii
Descriptor: Dynein gamma chain, flagellar outer arm, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Walton, T, Wu, H, Brown, A.B.
Deposit date:2020-12-10
Release date:2021-01-20
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
4AKG
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BU of 4akg by Molmil
Dynein Motor Domain - ATP complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, ...
Authors:Schmidt, H, Gleave, E.S, Carter, A.P.
Deposit date:2012-02-22
Release date:2012-03-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
8FDU
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BU of 8fdu by Molmil
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-04
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
7Z8I
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BU of 7z8i by Molmil
The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-08-17
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
4AI6
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BU of 4ai6 by Molmil
Dynein Motor Domain - ADP complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, ...
Authors:Schmidt, H, Gleave, E.S, Carter, A.P.
Deposit date:2012-02-08
Release date:2012-03-14
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
8FCY
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BU of 8fcy by Molmil
Engineered human dynein motor domain in microtubule-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
4RH7
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BU of 4rh7 by Molmil
Crystal structure of human cytoplasmic dynein 2 motor domain in complex with ADP.Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ...
Authors:Schmidt, H, Zalyte, R, Urnavicius, L, Carter, A.P.
Deposit date:2014-10-01
Release date:2014-12-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Structure of human cytoplasmic dynein-2 primed for its power stroke.
Nature, 518, 2015
7Z8H
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BU of 7z8h by Molmil
Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7K58
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BU of 7k58 by Molmil
Structure of outer-arm dyneins bound to microtubule with microtubule binding state 1(MTBS-1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Qinhui, R, Kai, Z.
Deposit date:2020-09-16
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
Nat.Struct.Mol.Biol., 28, 2021
7MI3
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BU of 7mi3 by Molmil
Signal subtracted reconstruction of AAA2, AAA3, and AAA4 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 4
Descriptor: (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ...
Authors:Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-11-03
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
7Z8G
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BU of 7z8g by Molmil
Cytoplasmic dynein-1 motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
4W8F
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BU of 4w8f by Molmil
Crystal structure of the dynein motor domain in the AMPPNP-bound state
Descriptor: Dynein heavy chain lysozyme chimera, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Cheng, H.-C, Bhabha, G, Zhang, N, Vale, R.D.
Deposit date:2014-08-24
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.541 Å)
Cite:Allosteric communication in the Dynein motor domain.
Cell, 159, 2014
4AKH
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BU of 4akh by Molmil
Dynein Motor Domain - AMPPNP complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, DYNEIN HEAVY CHAIN CYTOPLASMIC, ...
Authors:Schmidt, H, Gleave, E.S, Carter, A.P.
Deposit date:2012-02-22
Release date:2012-03-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
8E00
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BU of 8e00 by Molmil
Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Reimer, J.M, Lahiri, I, Leschziner, A.E.
Deposit date:2022-08-08
Release date:2023-08-30
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
4AKI
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BU of 4aki by Molmil
Dynein Motor Domain - LuAc derivative
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, DYNEIN HEAVY CHAIN CYTOPLASMIC, ...
Authors:Schmidt, H, Gleave, E.S, Carter, A.P.
Deposit date:2012-02-22
Release date:2012-03-14
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
7MI8
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BU of 7mi8 by Molmil
Signal subtracted reconstruction of AAA5 and AAA6 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 5
Descriptor: Fusion protein of Dynein and Endolysin
Authors:Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-11-03
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
5NUG
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BU of 5nug by Molmil
Motor domains from human cytoplasmic dynein-1 in the phi-particle conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Zhang, K, Foster, H.E, Carter, A.P.
Deposit date:2017-04-30
Release date:2017-06-28
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Cell, 169, 2017
3VKH
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BU of 3vkh by Molmil
X-ray structure of a functional full-length dynein motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Dynein heavy chain, cytoplasmic
Authors:Kon, T, Oyama, T, Shimo-Kon, R, Suto, K, Kurisu, G.
Deposit date:2011-11-16
Release date:2012-03-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The 2.8 A crystal structure of the dynein motor domain
Nature, 484, 2012
6SC2
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BU of 6sc2 by Molmil
Structure of the dynein-2 complex; IFT-train bound model
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 2 light intermediate chain 1, ...
Authors:Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J.
Deposit date:2019-07-23
Release date:2019-09-04
Last modified:2019-09-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the dynein-2 complex and its assembly with intraflagellar transport trains.
Nat.Struct.Mol.Biol., 26, 2019
7MI6
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BU of 7mi6 by Molmil
Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1
Descriptor: (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ...
Authors:Santarossa, C.C, Urnavicius, L, Coudray, N, Ekeirt, D.C, Bhabha, G, Kapoor, T.M.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-11-03
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021

 

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