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1ILE
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BU of 1ile by Molmil
ISOLEUCYL-TRNA SYNTHETASE
Descriptor: ISOLEUCYL-TRNA SYNTHETASE, ZINC ION
Authors:Nureki, O, Vassylyev, D.G, Tateno, M, Shimada, A, Nakama, T, Fukai, S, Konno, M, Schimmel, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-02-24
Release date:1999-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science, 280, 1998
1QU2
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor: ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, ...
Authors:Silvian, L.F, Wang, J, Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1QU3
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor: ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MUPIROCIN, ...
Authors:Silvian, L.F, Wang, J, Steitz, T.A.
Deposit date:1999-07-06
Release date:1999-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1FFY
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BU of 1ffy by Molmil
INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
Descriptor: ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, MAGNESIUM ION, ...
Authors:Silvian, L.F, Wang, J, Steitz, T.A.
Deposit date:2000-07-26
Release date:2000-08-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1GAX
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BU of 1gax by Molmil
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor: N-[VALINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, TRNA(VAL), VALYL-TRNA SYNTHETASE, ...
Authors:Fukai, S, Nureki, O, Sekine, S, Shimada, A, Tao, J, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2000-06-23
Release date:2000-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase.
Cell(Cambridge,Mass.), 103, 2000
1JZQ
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BU of 1jzq by Molmil
Isoleucyl-tRNA synthetase Complexed with Isoleucyl-adenylate analogue
Descriptor: Isoleucyl-tRNA synthetase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ZINC ION
Authors:Nakama, T, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1JZS
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Isoleucyl-tRNA synthetase Complexed with mupirocin
Descriptor: Isoleucyl-tRNA synthetase, MUPIROCIN, ZINC ION
Authors:Nakama, T, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2001-09-17
Release date:2001-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase.
J.Biol.Chem., 276, 2001
1H3N
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Leucyl-tRNA synthetase from Thermus thermophilus complexed with a sulphamoyl analogue of leucyl-adenylate
Descriptor: LEUCINE, LEUCYL-TRNA SYNTHETASE, SULFATE ION, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
1IVS
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BU of 1ivs by Molmil
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS VALYL-TRNA SYNTHETASE COMPLEXED WITH TRNA(VAL) AND VALYL-ADENYLATE ANALOGUE
Descriptor: N-[VALINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, Valyl-tRNA synthetase, tRNA (Val)
Authors:Fukai, S, Nureki, O, Sekine, S.-I, Shimada, A, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-29
Release date:2003-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1OBH
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BU of 1obh by Molmil
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor: LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, NORVALINE, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2003-01-31
Release date:2003-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBC
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor: 2'-AMINO-2'-DEOXYADENOSINE, LEUCINE, LEUCYL-TRNA SYNTHETASE, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2003-01-30
Release date:2003-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1IYW
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BU of 1iyw by Molmil
Preliminary Structure of Thermus thermophilus Ligand-Free Valyl-tRNA Synthetase
Descriptor: Valyl-tRNA Synthetase
Authors:Fukai, S, Nureki, O, Sekine, S, Shimada, A, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-09-10
Release date:2003-06-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (4 Å)
Cite:Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
RNA, 9, 2003
1WKB
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BU of 1wkb by Molmil
Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation
Descriptor: Leucyl-tRNA synthetase, SULFATE ION
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-30
Release date:2005-02-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Leucyl-tRNA Synthetase from the Archaeon Pyrococcus horikoshii Reveals a Novel Editing Domain Orientation
J.Mol.Biol., 346, 2005
1WZ2
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BU of 1wz2 by Molmil
The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex
Descriptor: Leucyl-tRNA synthetase, tRNA
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-02-21
Release date:2005-09-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex
to be published
2BYT
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BU of 2byt by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation
Descriptor: LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ...
Authors:Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
Deposit date:2005-08-04
Release date:2005-09-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2BTE
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BU of 2bte by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation and a post- transfer editing substrate analogue
Descriptor: 2'-AMINO-2'-DEOXYADENOSINE, AMINOACYL-TRNA SYNTHETASE, LEUCINE, ...
Authors:Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
Deposit date:2005-05-31
Release date:2005-09-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2CSX
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BU of 2csx by Molmil
Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met)
Descriptor: Methionyl-tRNA synthetase, RNA (75-MER)
Authors:Nakanishi, K, Ogiso, Y, Nakama, T, Fukai, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2CT8
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BU of 2ct8 by Molmil
Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) and methionyl-adenylate anologue
Descriptor: 5'-O-[(L-METHIONYL)-SULPHAMOYL]ADENOSINE, Methionyl-tRNA synthetase, RNA (74-MER)
Authors:Nakanishi, K, Ogiso, Y, Nakama, T, Fukai, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-23
Release date:2005-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol., 12, 2005
2V0G
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BU of 2v0g by Molmil
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site.
Descriptor: AMINOACYL-TRNA SYNTHETASE, LEUCINE, MERCURY (II) ION, ...
Authors:Rock, F, Mao, W, Yaremchuk, A, Tukalo, M, Crepin, T, Zhou, H, Zhang, Y, Hernandez, V, Akama, T, Baker, S, Plattner, J, Shapiro, L, Martinis, S.A, Benkovic, S.J, Cusack, S, Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
2V0C
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site
Descriptor: AMINOACYL-TRNA SYNTHETASE, LEUCINE, SULFATE ION, ...
Authors:Rock, F, Mao, W, Yaremchuk, A, Tukalo, M, Crepin, T, Zhou, H, Zhang, Y, Hernandez, V, Akama, T, Baker, S, Plattner, J, Shapiro, L, Martinis, S.A, Benkovic, S.J, Cusack, S, Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
4ARC
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BU of 4arc by Molmil
Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucine in the editing conformation
Descriptor: LEUCINE, LEUCINE--TRNA LIGASE, MAGNESIUM ION, ...
Authors:Palencia, A, Crepin, T, Vu, M.T, Lincecum Jr, T.L, Martinis, S.A, Cusack, S.
Deposit date:2012-04-23
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4AQ7
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Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation
Descriptor: E. COLI TRNALEU UAA ISOACCEPTOR, LEUCINE, LEUCINE--TRNA LIGASE, ...
Authors:Palencia, A, Crepin, T, Vu, M.T, Lincecum Jr, T.L, Martinis, S.A, Cusack, S.
Deposit date:2012-04-13
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4AS1
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Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation
Descriptor: LEUCINE--TRNA LIGASE, MAGNESIUM ION, TRNA-LEU5 (UAA ISOACEPTOR)
Authors:Palencia, A, Crepin, T, Vu, M.T, Lincecum Jr, T.L, Martinis, S.A, Cusack, S.
Deposit date:2012-04-27
Release date:2012-06-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4ARI
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BU of 4ari by Molmil
Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole AN2679 in the editing conformation
Descriptor: GLYCEROL, LEUCINE--TRNA LIGASE, MAGNESIUM ION, ...
Authors:Palencia, A, Crepin, T, Vu, M.T, Lincecum Jr, T.L, Martinis, S.A, Cusack, S.
Deposit date:2012-04-24
Release date:2012-06-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
3ZGZ
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Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from agrocin 84 (TM84) in aminoacylation-like conformation
Descriptor: LEUCINE--TRNA LIGASE, MAGNESIUM ION, TRNA-LEU UAA ISOACCEPTOR, ...
Authors:Chopra, S, Palencia, A, Virus, C, Tripathy, A, Temple, B.R, Velazquez-Campoy, A, Cusack, S, Reader, J.S.
Deposit date:2012-12-19
Release date:2013-01-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013

 

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