1EBM
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CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Bruner, S.D., Norman, D.P., Verdine, G.L.
Deposit date:2000-01-24
Release date:2000-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Nature, 403, 2000
1FN7
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COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
Descriptor:DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE 1, ...
Authors:Norman, D.P.G., Bruner, S.D., Verdine, G.L.
Deposit date:2000-08-21
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
J.Am.Chem.Soc., 123, 2001
1HU0
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CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE 1, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2001-01-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Product-Assisted Catalysis in base-excision DNA Repair
Nat.Struct.Biol., 10, 2003
1KO9
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NATIVE STRUCTURE OF THE HUMAN 8-OXOGUANINE DNA GLYCOSYLASE HOGG1
Descriptor:8-oxoguanine DNA glycosylase, SULFATE ION
Authors:Bjoras, M., Seeberg, E., Luna, L., Pearl, L.H., Barrett, T.E.
Deposit date:2001-12-20
Release date:2002-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.
J.Mol.Biol., 317, 2002
1LWV
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BOROHYDRIDE-TRAPPED HOGG1 INTERMEDIATE STRUCTURE CO-CRYSTALLIZED WITH 8-AMINOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1LWW
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BOROHYDRIDE-TRAPPED HOGG1 INTERMEDIATE STRUCTURE CO-CRYSTALLIZED WITH 8-BROMOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1LWY
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HOGG1 BOROHYDRIDE-TRAPPED INTERMEDIATE WITHOUT 8-OXOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1M3H
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CRYSTAL STRUCTURE OF HOGG1 D268E MUTANT WITH PRODUCT OLIGONUCLEOTIDE
Descriptor:5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(P*GP*CP*GP*TP*CP*CP*AP*(DDX))-3', 5'-D(P*GP*TP*CP*TP*AP*CP*C)-3', ...
Authors:Chung, S.J., Verdine, G.L.
Deposit date:2002-06-27
Release date:2004-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of End Products Resulting from Lesion Processing by a DNA Glycosylase/Lyase
Chem.Biol., 11, 2004
1M3Q
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CRYSTAL STRUCTURE OF HOGG1 D268E MUTANT WITH BASE-EXCISED DNA AND 8-AMINOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(DRZ)P*GP*TP*CP*TP*AP*CP*C)-3', 8-oxoguanine DNA glycosylase, ...
Authors:Chung, S.J., Verdine, G.L.
Deposit date:2002-06-28
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of End Products Resulting from Lesion Processing by a DNA Glycosylase/Lyase
Chem.Biol., 11, 2004
1N39
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STRUCTURAL AND BIOCHEMICAL EXPLORATION OF A CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINE GLYCOSYLASE
Descriptor:DNA complement strand, DNA inhibitor strand, N-glycosylase/DNA lyase, ...
Authors:Norman, D.P., Chung, S.J., Verdine, G.L.
Deposit date:2002-10-25
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003
1N3A
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STRUCTURAL AND BIOCHEMICAL EXPLORATION OF A CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINE GLYCOSYLASE
Descriptor:DNA complement strand, DNA inhibitor strand, N-glycosylase/DNA lyase, ...
Authors:Norman, D.P., Chung, S.J., Verdine, G.L.
Deposit date:2002-10-25
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003
1N3C
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STRUCTURAL AND BIOCHEMICAL EXPLORATION OF A CRITICAL AMINO ACID IN HUMAN 8-OXOGUANINE GLYCOSYLASE
Descriptor:DNA complement strand, 8-oxoG-containing DNA, N-glycosylase/DNA lyase, ...
Authors:Norman, D.P., Chung, S.J., Verdine, G.L.
Deposit date:2002-10-25
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003
1YQK
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HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED WITH GUANINE CONTAINING DNA
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*G)-3', 5'-D(P*CP*AP*GP*GP*TP*CP*TP*AP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2005-02-01
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
Nature, 434, 2005
1YQL
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CATALYTICALLY INACTIVE HOGG1 CROSSLINKED WITH 7-DEAZA-8-AZAGUANINE CONTAINING DNA
Descriptor:5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*CP*AP*(PPW)P*GP*TP*CP*TP*AP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2005-02-02
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
Nature, 434, 2005
1YQM
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CATALYTICALLY INACTIVE HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED TO 7-DEAZAGUANINE CONTAINING DNA
Descriptor:5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*CP*AP*(7GU)P*GP*TP*CP*TP*AP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2005-02-02
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
Nature, 434, 2005
1YQR
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CATALYTICALLY INACTIVE HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED TO OXOG CONTAINING DNA
Descriptor:5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(P*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2005-02-02
Release date:2005-04-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
Nature, 434, 2005
2I5W
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STRUCTURE OF HOGG1 CROSSLINKED TO DNA SAMPLING A NORMAL G ADJACENT TO AN OXOG
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*A)-3', 5'-D(P*CP*CP*AP*GP*(G42)P*TP*CP*TP*AP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Verdine, G.L.
Deposit date:2006-08-26
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2NOB
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STRUCTURE OF CATALYTICALLY INACTIVE H270A HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED TO 8-OXOGUANINE DNA
Descriptor:5'-D(*T*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOE
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STRUCTURE OF CATALYTICALLY INACTIVE G42A HUMAN 8-OXOGUANINE GLYCOSYLASE COMPLEXED TO 8-OXOGUANINE DNA
Descriptor:5'-D(*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOF
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STRUCTURE OF Q315F HUMAN 8-OXOGUANINE GLYCOSYLASE PROXIMAL CROSSLINK TO 8-OXOGUANINE DNA
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*C*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOH
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STRUCTURE OF CATALYTICALLY INACTIVE Q315A HUMAN 8-OXOGUANINE GLYCOSYLASE COMPLEXED TO 8-OXOGUANINE DNA
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOI
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STRUCTURE OF G42A HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED TO UNDAMAGED G-CONTAINING DNA
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*C*CP*AP*GP*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOL
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STRUCTURE OF CATALYTICALLY INACTIVE HUMAN 8-OXOGUANINE GLYCOSYLASE DISTAL CROSSLINK TO OXOG DNA
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Banerjee, A., Radom, C.T., Verdine, G.L.
Deposit date:2006-10-25
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2NOZ
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STRUCTURE OF Q315F HUMAN 8-OXOGUANINE GLYCOSYLASE DISTAL CROSSLINK TO 8-OXOGUANINE DNA
Descriptor:5'-D(*GP*G*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', N-glycosylase/DNA lyase, ...
Authors:Radom, C.T., Banerjee, A., Verdine, G.L.
Deposit date:2006-10-26
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.
J.Biol.Chem., 282, 2007
2XHI
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SEPARATION-OF-FUNCTION MUTANTS UNRAVEL THE DUAL REACTION MODE OF HUMAN 8-OXOGUANINE DNA GLYCOSYLASE
Descriptor:N-GLYCOSYLASE/DNA LYASE, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3', ...
Authors:Dalhus, B., Forsbring, M., Helle, I.H., Backe, P.H., Forstrom, R.J., Alseth, I., Bjoras, M.
Deposit date:2010-06-16
Release date:2011-01-26
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Separation-of-Function Mutants Unravel the Dual- Reaction Mode of Human 8-Oxoguanine DNA Glycosylase.
Structure, 19, 2011
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