1J7N
 
 | | Anthrax Toxin Lethal factor | | Descriptor: | Lethal Factor precursor, SULFATE ION, ZINC ION | | Authors: | Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C. | | Deposit date: | 2001-05-17 | | Release date: | 2001-11-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
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1JKY
 | | Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2 | | Descriptor: | Lethal Factor, mitogen-activated protein kinase kinase 2 | | Authors: | Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C. | | Deposit date: | 2001-07-13 | | Release date: | 2001-11-07 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
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1PWP
 | | Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155 | | Descriptor: | Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION | | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | | Deposit date: | 2003-07-02 | | Release date: | 2004-01-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
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1PWQ
 | | Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor | | Descriptor: | Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION | | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | | Deposit date: | 2003-07-02 | | Release date: | 2004-01-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.52 Å) | | Cite: | The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
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1PWU
 | | Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases. | | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION | | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | | Deposit date: | 2003-07-02 | | Release date: | 2004-02-03 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
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1PWV
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1PWW
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1XFU
 | | Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin | | Descriptor: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1XFV
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ... | | Authors: | Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1XFW
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP) | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1XFX
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride | | Descriptor: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2017-12-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1XFY
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin | | Descriptor: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1XFZ
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride | | Descriptor: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | | Deposit date: | 2004-09-15 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
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1Y0V
 | | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate | | Descriptor: | CALCIUM ION, Calmodulin, Calmodulin-sensitive adenylate cyclase, ... | | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.-J. | | Deposit date: | 2004-11-16 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor
Embo J., 24, 2005
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1YQY
 | | Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor | | Descriptor: | (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION | | Authors: | Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A. | | Deposit date: | 2005-02-02 | | Release date: | 2005-05-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Anthrax lethal factor inhibition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1ZXV
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2L0R
 | | Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center | | Descriptor: | Lethal factor | | Authors: | Dalkas, G.A, Chasapis, C.T, Gkazonis, P.V, Bentrop, D.A, Spyroulias, G.A. | | Deposit date: | 2010-07-15 | | Release date: | 2010-12-22 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Conformational dynamics of the anthrax lethal factor catalytic center.
Biochemistry, 49, 2010
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2N6J
 | | Solution structure of Zmp1, a zinc-dependent metalloprotease secreted by Clostridium difficile | | Descriptor: | ZINC ION, Zinc metalloprotease Zmp1 | | Authors: | Banci, L, Cantini, F, Scarselli, M, Rubino, J.T, Martinelli, M. | | Deposit date: | 2015-08-24 | | Release date: | 2016-01-13 | | Last modified: | 2016-04-06 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of zinc-bound Zmp1, a zinc-dependent metalloprotease secreted by Clostridium difficile.
J.Biol.Inorg.Chem., 21, 2016
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3KWV
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4DV8
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4FXQ
 | | Full-length Certhrax toxin from Bacillus cereus in complex with Inhibitor P6 | | Descriptor: | 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, Putative ADP-ribosyltransferase Certhrax, ... | | Authors: | Visschedyk, D.D, Dimov, S, Kimber, M.S, Park, H.W, Merrill, A.R. | | Deposit date: | 2012-07-03 | | Release date: | 2012-09-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9599 Å) | | Cite: | Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
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4GF1
 | | Crystal Structure of Certhrax | | Descriptor: | Putative ADP-ribosyltransferase Certhrax, UNKNOWN ATOM OR ION | | Authors: | Hong, B.S, Dimov, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-08-02 | | Release date: | 2012-09-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
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4PKQ
 | | Anthrax toxin lethal factor with bound zinc | | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ... | | Authors: | Maize, K.M, Finzel, B.C. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
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4PKR
 | | Anthrax toxin lethal factor with bound small molecule inhibitor 10 | | Descriptor: | CHLORIDE ION, GLYCEROL, Lethal factor, ... | | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
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4PKS
 | | Anthrax toxin lethal factor with bound small molecule inhibitor 11 | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ... | | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | | Deposit date: | 2014-05-15 | | Release date: | 2014-11-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
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