1HZF
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C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A
Descriptor:COMPLEMENT FACTOR C4A
Authors:van den Elsen, J.M.H., Martin, A., Wong, V., Clemenza, L., Rose, D.R., Isenman, D.E.
Deposit date:2001-01-24
Release date:2002-10-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray crystal structure of the C4d fragment of human complement component C4.
J.Mol.Biol., 322, 2002
4ZIU
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CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING THE RESIDUES FROM DOMAIN MG7 TO THE C-TERMINUS.
Descriptor:Uncharacterized lipoprotein YfhM, NICKEL (II) ION, GLYCEROL
Authors:Garcia-Ferrer, I., Arede, P., Gomez-Blanco, J., Luque, D., Duquerroy, S., Caston, J.R., Goulas, T., Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
2A73
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HUMAN COMPLEMENT COMPONENT C3
Descriptor:Complement C3, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., Nilsson-Ekdahl, K., Nilsson, B., Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2B39
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STRUCTURE OF MAMMALIAN C3 WITH AN INTACT THIOESTER AT 3A RESOLUTION
Descriptor:C3, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Fredslund, F., Jenner, L., Husted, L.B., Nyborg, J., Andersen, G.R., Sottrup-Jensen, L.
Deposit date:2005-09-20
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of bovine complement component 3 reveals the basis for thioester function.
J.Mol.Biol., 361, 2006
2I07
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HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3b, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Janssen, B.J.C., Christodoulidou, A., McCarthy, A., Lambris, J.D., Gros, P.
Deposit date:2006-08-10
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of C3b reveals conformational changes that underlie complement activity.
Nature, 444, 2006
2ICF
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CRIG BOUND TO C3B
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, V-set and immunoglobulin domain-containing protein 4, ...
Authors:Wiesmann, C.
Deposit date:2006-09-12
Release date:2006-11-07
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2PN5
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CRYSTAL STRUCTURE OF TEP1R
Descriptor:Thioester-containing protein I, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Baxter, R.H.G.
Deposit date:2007-04-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural basis for conserved complement factor-like function in the antimalarial protein TEP1
Proc.Natl.Acad.Sci.Usa, 104, 2007
2WII
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COMPLEMENT C3B IN COMPLEX WITH FACTOR H DOMAINS 1-4
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H, ...
Authors:Wu, J., Janssen, B.J.C., Gros, P.
Deposit date:2009-05-12
Release date:2009-06-09
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nat. Immunol., 10, 2009
2WIN
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C3 CONVERTASE (C3BBB) STABILIZED BY SCIN
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B, ...
Authors:Wu, J., Janssen, B.J., Gros, P.
Deposit date:2009-05-13
Release date:2009-06-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Nat. Immunol., 10, 2009
2XWB
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D
Descriptor:COMPLEMENT C3B BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B, ...
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-01
Release date:2011-01-12
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
2XWJ
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B, ...
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-04
Release date:2011-01-12
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
3CU7
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HUMAN COMPLEMENT COMPONENT 5
Descriptor:Complement C5, N-ACETYL-D-GLUCOSAMINE, CADMIUM ION
Authors:Fredslund, F., Andersen, G.R.
Deposit date:2008-04-16
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
3G6J
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C3B IN COMPLEX WITH A C3B SPECIFIC FAB
Descriptor:Complement C3 beta chain, Complement C3 alpha chain, Fab light chain, ...
Authors:Wiesmann, C.
Deposit date:2009-02-06
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
3KLS
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH SSL7
Descriptor:Complement C5, Exotoxin 1, CADMIUM ION, ...
Authors:Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH THE C-TERMINAL BETA-GRASP DOMAIN OF SSL7
Descriptor:Complement C5, Staphylococcal enterotoxin-like toxin, CADMIUM ION, ...
Authors:Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3L5N
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3PRX
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF AND SSL7
Descriptor:Complement C5, Cobra venom factor, Superantigen-like protein 7, ...
Authors:Laursen, N.S., Andersen, G.R., Sottrup-Jensen, L., Andersen, K.R., Spillner, E., Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3PVM
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF
Descriptor:Complement C5, Cobra venom factor, N-ACETYL-D-GLUCOSAMINE
Authors:Laursen, N.S., Andersen, K.R., Braren, I., Sottrup-Jensen, L., Spillner, E., Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The Crystal Structure of Human Alpha(2)-Macroglobulin Reveals a Unique Molecular Cage.
Angew.Chem.Int.Ed.Engl., 51, 2012
4D94
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CRYSTAL STRUCTURE OF TEP1R
Descriptor:Thioester-containing protein 1, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Le, B.V., Williams, M., Logarajah, S., Baxter, R.H.G.
Deposit date:2012-01-11
Release date:2012-10-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles.
Plos Pathog., 8, 2012
4E0S
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CRYSTAL STRUCTURE OF C5B-6
Descriptor:Complement C5, Complement component C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Aleshin, A.E., Stec, B., DiScipio, R., Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
4FXG
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COMPLEMENT C4 IN COMPLEX WITH MASP-2
Descriptor:Complement C4 beta chain, Complement C4-A alpha chain, Complement C4 gamma chain, ...
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FXK
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HUMAN COMPLEMENT C4
Descriptor:Complement C4 Beta chain, Complement C4-A Alpha chain, Complement C4 gamma chain, ...
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4LNV
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CRYSTAL STRUCTURE OF TEP1S
Descriptor:Thioester-containing protein I, N-ACETYL-D-GLUCOSAMINE
Authors:Le, B.V., Williams, M., Logarajah, S., Baxter, R.H.G.
Deposit date:2013-07-12
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles.
Plos Pathog., 8, 2012
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