3GO8
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MUTM ENCOUNTERING AN INTRAHELICAL 8-OXOGUANINE (OXOG) LESION IN EC3-LOOP DELETION COMPLEX
Descriptor:DNA glycosylase, 5'-D(P*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*CP*G)-3', 5'-D(*GP*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*C)-3', ...
Authors:Spong, M.C., Qi, Y., Verdine, G.L.
Deposit date:2009-03-18
Release date:2009-12-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme
Nature, 462, 2009
3GPU
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MUTM ENCOUNTERING AN INTRAHELICAL 8-OXOGUANINE (OXOG) LESION IN EC4-LOOP DELETION COMPLEX
Descriptor:DNA glycosylase, DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(8OG)P*AP*GP*TP*CP*TP*AP*CP*C)-3'), ...
Authors:Banerjee, A., Qi, Y., Verdine, G.L.
Deposit date:2009-03-23
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
3GPX
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SEQUENCE-MATCHED MUTM INTERROGATION COMPLEX 4 (IC4)
Descriptor:DNA glycosylase, DNA (5'-D(*A*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*AP*GP*TP*CP*TP*AP*CP*C)-3'), ...
Authors:Spong, M.C., Qi, Y., Verdine, G.L.
Deposit date:2009-03-23
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
3GQ3
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MUTM ENCOUNTERING AN INTRAHELICAL 8-OXOGUANINE (OXOG) LESION IN EC5-LOOP DELETION COMPLEX
Descriptor:DNA glycosylase, DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), ...
Authors:Banerjee, A., Qi, Y., Verdine, G.L.
Deposit date:2009-03-23
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
1EE8
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CRYSTAL STRUCTURE OF MUTM (FPG) PROTEIN FROM THERMUS THERMOPHILUS HB8
Descriptor:MUTM (FPG) PROTEIN, ZINC ION
Authors:Sugahara, M., Mikawa, T., Kumasaka, T., Yamamoto, M., Kato, R., Fukuyama, K., Inoue, Y., Kuramitsu, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2000-01-31
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8.
EMBO J., 19, 2000
1K3W
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CRYSTAL STRUCTURE OF A TRAPPED REACTION INTERMEDIATE OF THE DNA REPAIR ENZYME ENDONUCLEASE VIII WITH DNA
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Gilboa, R., Fernandes, A.S., Kycia, J.H., Gerchman, S.E., Rieger, R.A., Grollman, A.P., Shoham, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
1K3X
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CRYSTAL STRUCTURE OF A TRAPPED REACTION INTERMEDIATE OF THE DNA REPAIR ENZYME ENDONUCLEASE VIII WITH BROMINATED-DNA
Descriptor:5'-D(*GP*GP*CP*(BRU)P*(BRU)P*CP*AP*(BRU)P*CP*CP*(BRU)P*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Gilboa, R., Fernandes, A.S., Kycia, J.H., Gerchman, S.E., Rieger, R.A., Grollman, A.P., Shoham, G.
Deposit date:2001-10-04
Release date:2002-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate.
EMBO J., 21, 2002
1K82
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CRYSTAL STRUCTURE OF E.COLI FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FPG) COVALENTLY TRAPPED WITH DNA
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*CP*TP*CP*CP*TP*GP*G)-3', 5'-D(*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', formamidopyrimidine-DNA glycosylase, ...
Authors:Gilboa, R., Zharkov, D.O., Golan, G., Fernandes, A.S., Gerchman, S.E., Matz, E., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2001-10-22
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA.
J.Biol.Chem., 277, 2002
1KFV
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CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS FORMAMIDO-PYRIMIDINE DNA GLYCOSYLASE (ALIAS FPG OR MUTM) NON COVALENTLY BOUND TO AN AP SITE CONTAINING DNA.
Descriptor:5'-D(*CP*TP*CP*TP*TP*TP*(PDI)P*TP*TP*TP*CP*TP*C)-3', 5'-D(*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*AP*G)-3', Formamido-pyrimidine DNA glycosylase, ...
Authors:Serre, L., Pereira de Jesus, K., Boiteux, S., Zelwer, C., Castaing, B.
Deposit date:2001-11-23
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA.
EMBO J., 21, 2002
1NNJ
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CRYSTAL STRUCTURE COMPLEX BETWEEN THE LACTOCOCCUS LACTIS FPG AND AN ABASIC SITE CONTAINING DNA
Descriptor:5'-D(*CP*TP*CP*TP*TP*TP*(PDI)P*TP*TP*TP*CP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', Formamidopyrimidine-DNA glycosylase, ...
Authors:Serre, L., Pereira de Jesus, K., Boiteux, S., Zelwer, C., Castaing, B.
Deposit date:2003-01-14
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
Nucleic Acids Res., 33, 2005
1PJI
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CRYSTAL STRUCTURE OF WILD TYPE LACTOCOCCUS LACTIS FPG COMPLEXED TO A 1,3 PROPANEDIOL CONTAINING DNA
Descriptor:DNA (5'-D(*CP*TP*CP*TP*TP*TP*(PDI)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Pereira, K., Serre, L., Zelwer, C., Castaing, B.
Deposit date:2003-06-03
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
Nucleic Acids Res., 33, 2005
1PJJ
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COMPLEX BETWEEN THE LACTOCOCCUS LACTIS FPG AND AN ABASIC SITE CONTAINING DNA.
Descriptor:DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Serre, L., Pereira de Jesus, K., Boiteux, S., Zelwer, C., Castaing, B.
Deposit date:2003-06-03
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
Nucleic Acids Res., 33, 2005
1PM5
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CRYSTAL STRUCTURE OF WILD TYPE LACTOCOCCUS LACTIS FPG COMPLEXED TO A TETRAHYDROFURAN CONTAINING DNA
Descriptor:DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Pereira de Jesus-Tran, K., Serre, L., Zelwer, C., Castaing, B.
Deposit date:2003-06-10
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues-containing DNA.
Nucleic Acids Res., 33, 2005
1Q39
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE WT ENZYME AT 2.8 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, CALCIUM ION
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1Q3B
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE R252A MUTANT AT 2.05 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, MAGNESIUM ION, ...
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1Q3C
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI: THE E2A MUTANT AT 2.3 RESOLUTION.
Descriptor:Endonuclease VIII, ZINC ION, MAGNESIUM ION, ...
Authors:Golan, G., Zharkov, D.O., Feinberg, H., Fernandes, A.S., Zaika, E.I., Kycia, J.H., Grollman, A.P., Shoham, G.
Deposit date:2003-07-29
Release date:2004-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility.
Nucleic Acids Res., 33, 2005
1XC8
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CRYSTAL STRUCTURE COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND A FAPY-DG CONTAINING DNA
Descriptor:5'-D(*CP*TP*CP*TP*TP*TP*(FOX)P*TP*TP*TP*CP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', Formamidopyrimidine-DNA glycosylase, ...
Authors:Coste, F., Ober, M., Carell, T., Boiteux, S., Zelwer, C., Castaing, B.
Deposit date:2004-09-01
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase.
J.Biol.Chem., 279, 2004
2EA0
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharov, D.O., Grollman, A.P., Shoham, G.
Deposit date:2007-01-29
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues
To be Published
2OPF
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI (R252A) IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3', 5'-D(P*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharov, D.O., Grollman, A.P., Shoham, G.
Deposit date:2007-01-29
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrates and mutations of critical residues
To be Published
2OQ4
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CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME ENDONUCLEASE-VIII (NEI) FROM E. COLI (E2Q) IN COMPLEX WITH AP-SITE CONTAINING DNA SUBSTRATE
Descriptor:5'-D(*G*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*GP*G)-3', 5'-D(*C*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3', Endonuclease VIII, ...
Authors:Golan, G., Zharkov, D.O., Grollman, A.P., Shoahm, G.
Deposit date:2007-01-31
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site plasticity of endonuclease VIII: Conformational changes compensating for different substrates and mutations of critical residues
To be Published
2XZF
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND AN OXIDIZED PYRIMIDINE CONTAINING DNA AT 293K
Descriptor:FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE, 5'-D(*CP*TP*CP*TP*TP*TP*VETP*TP*TP*TP*CP*TP*CP*GP)-3', 5'-D(*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*AP*GP*CP)-3', ...
Authors:LeBihan, Y.V., Izquierdo, M.A., Coste, F., Culard, F., Gehrke, T.H., Essalhi, K., Aller, P., Carrel, T., Castaing, B.
Deposit date:2010-11-25
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:5-Hydroxy-5-Methylhydantoin DNA Lesion, a Molecular Trap for DNA Glycosylases
Nucleic Acids Res., 39, 2011
2XZU
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND AN OXIDIZED PYRIMIDINE CONTAINING DNA AT 310K
Descriptor:FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE, 5'-D(*CP*TP*CP*TP*TP*TP*VETP*TP*TP*TP*CP*TP*CP*G)-3', 5'-D(GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*G*A)-3', ...
Authors:Lebihan, Y.V., Izquierdo, M.A., Coste, F., Culard, F., Gehrke, T.H., Essalhi, K., Aller, P., Carrel, T., Castaing, B.
Deposit date:2010-11-29
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:5-Hydroxy-5-Methylhydantoin DNA Lesion, a Molecular Trap for DNA Glycosylases
Nucleic Acids Res., 39, 2011
3C58
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE WILD-TYPE LACTOCOCCUS LACTIS FPG (MUTM) AND A N7-BENZYL-FAPY-DG CONTAINING DNA
Descriptor:DNA (5'-D(*DGP*DCP*DGP*DAP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DGP*DA)-3'), DNA (5'-D(*DCP*DTP*DCP*DTP*DTP*DTP*(SOS)P*DTP*DTP*DTP*DCP*DTP*DCP*DG)-3'), DNA glycosylase, ...
Authors:Coste, F., Castaing, B., Carell, T.
Deposit date:2008-01-31
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode
Chem.Biol., 15, 2008
3GP1
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MUTM ENCOUNTERING AN INTRAHELICAL 8-OXOGUANINE (OXOG) LESION IN EC3-V222P COMPLEX
Descriptor:DNA glycosylase, 5'-D(*AP*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*CP*GP*CP**C)-3', 5'-D(P*TP*GP*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*CP*C)-3', ...
Authors:Spong, M.C., Qi, Y., Verdine, G.L.
Deposit date:2009-03-20
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme
Nature, 462, 2009
3GPP
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MUTM ENCOUNTERING AN INTRAHELICAL 8-OXOGUANINE (OXOG) LESION IN EC3-T224P COMPLEX
Descriptor:DNA glycosylase, DNA (5'-D(P*GP*GP*TP*AP*GP*AP*TP*CP*CP*GP*GP*AP*C)-3'), DNA (5'-D(P*CP*GP*TP*CP*CP*(8OG)P*GP*AP*TP*CP*TP*AP*C)-3'), ...
Authors:Spong, M.C., Qi, Y., Verdine, G.L.
Deposit date:2009-03-23
Release date:2009-11-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme.
Nature, 462, 2009
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