1JPY
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CRYSTAL STRUCTURE OF IL-17F
Descriptor:interleukin 17F, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hymowitz, S.G., Filvaroff, E.H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R., Pan, G., Gurney, A.L., de Vos, A.M., Starovasnik, M.A.
Deposit date:2001-08-03
Release date:2001-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
2VXS
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STRUCTURE OF IL-17A IN COMPLEX WITH A POTENT, FULLY HUMAN NEUTRALISING ANTIBODY
Descriptor:INTERLEUKIN-17A, FAB FRAGMENT, SULFATE ION
Authors:Gerhardt, S., Hargreaves, D., Pauptit, R.A., Davies, R.A., Russell, C., Welsh, F., Tuske, S.J., Coales, S.J., Hamuro, Y., Needham, M.R.C., Langham, C., Barker, W., Bell, P., Aziz, A., Smith, M.J., Dawson, S., Abbott, W.M.
Deposit date:2008-07-09
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structure of Il-17A in Complex with a Potent, Fully Human Neutralising Antibody.
J.Mol.Biol., 394, 2009
4HR9
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HUMAN INTERLEUKIN 17A
Descriptor:Interleukin-17A
Authors:Liu, S.
Deposit date:2012-10-26
Release date:2013-05-22
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun, 4, 2013
4QHU
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CRYSTAL STRUCTURE OF IL-17A/FAB6785 COMPLEX
Descriptor:Fab6785 light chain, Fab6785 heavy chain, Interleukin-17A, ...
Authors:Luo, J., Gilliland, G.L., Malia, T., Obmolova, G., Teplyakov, A.
Deposit date:2014-05-29
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation
To be Published
5HHV
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INHIBITING COMPLEX IL-17A AND IL-17RA INTERACTIONS WITH A LINEAR PEPTIDE
Descriptor:Interleukin-17A, CAT-2000 FAB heavy chain, IL-17A peptide inhibitor, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-06-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep, 6, 2016
5HHX
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INHIBITING COMPLEX IL-17A AND IL-17RA INTERACTIONS WITH A LINEAR PEPTIDE
Descriptor:Interleukin-17A, CAT-2000 FAB heavy chain, IL-17A peptide inhibitor, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-06-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep, 6, 2016
5HI3
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BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL-17A ANTAGONISTS
Descriptor:Interleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
5HI4
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BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL-17A ANTAGONISTS
Descriptor:Interleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
5HI5
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BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL-17A ANTAGONISTS
Descriptor:Interleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 light chain, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
5N7W
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COMPUTATIONALLY DESIGNED FUNCTIONAL ANTIBODY
Descriptor:Antibody Fragment Heavy Chain, Antibody Fragment Light Chain, Interleukin-17A
Authors:Hargreaves, D., Breed, J.
Deposit date:2017-02-21
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Computational design of epitope specific functional antibodies
Cell Rep, 2018
5N92
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CRYSTAL STRUCTURE OF HUMAN IL-17AF
Descriptor:Interleukin-17A, Interleukin-17F, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Rondeau, J.-M., Goepfert, A.
Deposit date:2017-02-24
Release date:2017-09-06
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
5VB9
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IL-17A IN COMPLEX WITH PEPTIDE
Descriptor:Interleukin-17A, Peptide inhibitor, 1,2-ETHANEDIOL, ...
Authors:Antonysamy, S., Russell, M., Zhang, A., Groshong, C., Manglicmot, D., Lu, F., Benach, J., Wasserman, S.R., Zhang, F., Afshar, S., Bina, H., Broughton, H., Chalmers, M., Dodge, J., Espada, A., Jones, S., Ting, J.P., Woodman, M.
Deposit date:2017-03-28
Release date:2018-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
PLoS ONE, 13, 2018
3JVF
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CRYSTAL STRUCTURE OF AN INTERLEUKIN-17 RECEPTOR COMPLEX
Descriptor:Interleukin-17F, Interleukin-17 receptor A, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ely, L.K., Garcia, K.C.
Deposit date:2009-09-16
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of receptor sharing by interleukin 17 cytokines.
Nat.Immunol., 10, 2009
4HSA
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STRUCTURE OF INTERLEUKIN 17A IN COMPLEX WITH IL17RA RECEPTOR
Descriptor:Interleukin-17A, Interleukin-17 receptor A, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Liu, S.
Deposit date:2012-10-29
Release date:2013-05-22
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun, 4, 2013
5NAN
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CRYSTAL STRUCTURE OF HUMAN IL-17AF IN COMPLEX WITH HUMAN IL-17RA
Descriptor:Interleukin-17A, Interleukin-17 receptor A, Interleukin-17F, ...
Authors:Rondeau, J.-M., Goepfert, A.
Deposit date:2017-02-28
Release date:2017-09-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
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