2BDE
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CRYSTAL STRUCTURE OF THE CYTOSOLIC IMP-GMP SPECIFIC 5'-NUCLEOTIDASE (LPG0095) FROM LEGIONELLA PNEUMOPHILA, NORTHEAST STRUCTURAL GENOMICS TARGET LGR1
Descriptor:cytosolic IMP-GMP specific 5'-nucleotidase, SULFATE ION
Authors:Forouhar, F., Abashidze, M., Ho, C.K., Conover, K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2005-10-20
Release date:2005-12-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the cytosolic IMP-GMP specific 5'-nucleotidase (lpg0095) from Legionella pneumophila, Northeast Structural Genomics Target LgR1
To be Published
2J2C
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II (NT5C2, CN-II)
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, SULFATE ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Loppnau, P., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-08-16
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JC9
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ADENOSINE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg, S.L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-21
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JCM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH BERYLLIUM TRIFLUORIDE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, UNKNOWN ATOM OR ION, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-27
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2XCV
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH INOSINE MONOPHOSPHATE AND 2,3-BISPHOSPHOGLYCERATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, (2R)-2,3-diphosphoglyceric acid, GLYCEROL, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-04-26
Release date:2011-03-16
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XCW
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH INOSINE MONOPHOSPHATE AND ATP
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-04-26
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XCX
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CRYSTAL STRUCTURE OF THE APOFORM OF THE D52N VARIANT OF CYTOSOLIC 5'- NUCLEOTIDASE II
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-04-26
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XJB
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH DEOXYGUANOSINE MONOPHOSPHATE AND DEOXYADENOSINE TRIPHOSPHATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-03
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XJC
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH GUANOSINE MONOPHOSPHATE AND DIADENOSINE TETRAPHOSPHATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GUANOSINE-5'-MONOPHOSPHATE, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-03
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XJD
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH INORGANIC PHOSPHATE AND DEOXYADENOSINE TRIPHOSPHATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-04
Release date:2011-04-27
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II.
J.Mol.Biol., 408, 2011
2XJE
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH URIDINE 5'-MONOPHOSPHATE AND ADENOSINE TRIPHOSPHATE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, URIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-04
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XJF
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CRYSTAL STRUCTURE OF THE D52N VARIANT OF CYTOSOLIC 5'-NUCLEOTIDASE II WITH A COVALENTLY MODIFIED ASN52
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, (2R)-2,3-diphosphoglyceric acid, GLYCEROL
Authors:Wallden, K., Nordlund, P.
Deposit date:2010-07-04
Release date:2011-03-16
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
4G63
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CRYSTAL STRUCTURE OF CYTOSOLIC IMP-GMP SPECIFIC 5'-NUCLEOTIDASE (LPG0095) IN COMPLEX WITH PHOSPHATE IONS FROM LEGIONELLA PNEUMOPHILA, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1
Descriptor:Cytosolic IMP-GMP specific 5'-nucleotidase, PHOSPHATE ION
Authors:Forouhar, F., Abashidze, M., Seetharaman, J., Ho, C.K., Ciccosanti, C., Mao, L., Xiao, R., Acton, T.B., Montelione, G.T., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-07-18
Release date:2012-10-10
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila.
Febs J., 281, 2014
4H4B
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HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ANTHRAQUINONE-2,6- DISULFONIC ACID
Descriptor:Cytosolic purine 5'-nucleotidase, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, GLYCEROL, ...
Authors:Rhimi, M., Aghajari, N.
Deposit date:2012-09-17
Release date:2012-12-26
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening.
Biochem Pharmacol, 85, 2013
4OHF
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CRYSTAL STRUCTURE OF CYTOSOLIC NUCLEOTIDASE II (LPG0095) IN COMPLEX WITH GMP FROM LEGIONELLA PNEUMOPHILA, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1
Descriptor:Cytosolic IMP-GMP specific 5'-nucleotidase, GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Srinivisan, B., Forouhar, F., Shukla, A., Sampangi, C., Kulkarni, S., Abashidze, M., Seetharaman, J., Lew, S., Mao, L., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.M., Tong, L., Balaram, H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-01-17
Release date:2014-02-26
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila.
Febs J., 281, 2014
5CQZ
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HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH 3-(3-IMIDAZOL-1-YLPHENYL)-N-(9H-PURIN-6-YL)BENZAMIDE
Descriptor:Cytosolic purine 5'-nucleotidase, GLYCEROL, SULFATE ION, ...
Authors:Preeti, P., Aghajari, N.
Deposit date:2015-07-22
Release date:2015-12-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
J.Med.Chem., 58, 2015
5CR7
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HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH N-(9H-PURIN-6-YL)-3-(3-PYRROL-1-YLPHENYL)BENZAMIDE
Descriptor:Cytosolic purine 5'-nucleotidase, ~{N}-(7~{H}-purin-6-yl)-3-(3-pyrrol-1-ylphenyl)benzamide, ACETATE ION, ...
Authors:Aghajari, N., Preeti, P.
Deposit date:2015-07-22
Release date:2016-01-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
J.Med.Chem., 58, 2015
5K7Y
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CRYSTAL STRUCTURE OF ENZYME IN PURINE METABOLISM
Descriptor:Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Skerlova, J., Hnizda, A., Pachl, P., Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5L4Z
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CRYSTAL STRUCTURE OF ENZYME IN PURINE METABOLISM
Descriptor:Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Hnizda, A., Pachl, P., Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5L50
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CRYSTAL STRUCTURE OF ENZYME IN PURINE METABOLISM
Descriptor:Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Hnizda, A., Pachl, P., Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.643 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5OPL
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CRYSTAL STRUCTURE OF K25E CN-II MUTANT
Descriptor:Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION
Authors:Kugler, M., Hnizda, A., Pachl, P., Rezacova, P.
Deposit date:2017-08-10
Release date:2018-06-13
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
6DD3
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CRYSTAL STRUCTURE OF THE DOUBLE MUTANT (D52N/D407A) OF NT5C2-537X IN THE ACTIVE STATE
Descriptor:Cytosolic purine 5'-nucleotidase, PHOSPHATE ION, GLYCEROL
Authors:Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L.
Deposit date:2018-05-09
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDB
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CRYSTAL STRUCTURE OF THE DOUBLE MUTANT (D52N/R367Q) OF NT5C2-537X IN THE BASAL STATE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET
Descriptor:Cytosolic purine 5'-nucleotidase, MANGANESE (II) ION, PHOSPHATE ION
Authors:Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2018-05-09
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDC
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CRYSTAL STRUCTURE OF THE SINGLE MUTANT (D52N) OF NT5C2-537X IN THE BASAL STATE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET
Descriptor:Cytosolic purine 5'-nucleotidase, MAGNESIUM ION, PHOSPHATE ION
Authors:Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2018-05-09
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDH
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CRYSTAL STRUCTURE OF THE DOUBLE MUTANT (D52N/R367Q) OF NT5C2-537X IN THE ACTIVE STATE, NORTHEAST STRUCTURAL GENOMICS TARGET
Descriptor:Cytosolic purine 5'-nucleotidase, INOSINIC ACID
Authors:Forouhar, F., Dieck, C.L., Tzoneva, G., Carpenter, Z., Ambesi-Impiombato, A., Sanchez-Martin, M., Kirschner-Schwabe, R., Lew, S., Seetharaman, J., Ferrando, A.A., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2018-05-10
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
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