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3JBL
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BU of 3jbl by Molmil
Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization
Descriptor: NLR family CARD domain-containing protein 4
Authors:Zhang, L, Chen, S, Ruan, J, Wu, J, Tong, A.B, Yin, Q, Li, Y, David, L, Lu, A, Wang, W.L, Marks, C, Ouyang, Q, Zhang, X, Mao, Y, Wu, H.
Deposit date:2015-09-05
Release date:2015-10-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
4KXF
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BU of 4kxf by Molmil
Crystal structure of NLRC4 reveals its autoinhibition mechanism
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NLR family CARD domain-containing protein 4, SULFATE ION
Authors:Chai, J, Hu, Z.
Deposit date:2013-05-25
Release date:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of NLRC4 reveals its autoinhibition mechanism
Science, 341, 2013
5AJ2
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BU of 5aj2 by Molmil
Cryo electron tomography of the Naip5-Nlrc4 inflammasome
Descriptor: NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4
Authors:Diebolder, C.A, Halff, E.F, Koster, A.J, Huizinga, E.G, Koning, R.I.
Deposit date:2015-02-20
Release date:2015-11-11
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (40 Å)
Cite:Cryoelectron Tomography of the Naip5/Nlrc4 Inflammasome: Implications for Nlr Activation.
Structure, 23, 2015
5IRL
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BU of 5irl by Molmil
Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRM
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BU of 5irm by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRN
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BU of 5irn by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5YUD
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BU of 5yud by Molmil
Flagellin derivative in complex with the NLR protein NAIP5
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1e, Phase 2 flagellin,Flagellin
Authors:Yang, X.R, Yang, F, Wang, W.G, Lin, G.Z.
Deposit date:2017-11-21
Release date:2018-01-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.28 Å)
Cite:Structural basis for specific flagellin recognition by the NLR protein NAIP5.
Cell Res., 28, 2018
6B5B
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BU of 6b5b by Molmil
Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome
Descriptor: Baculoviral IAP repeat-containing protein 1e, Flagellin, NLR family CARD domain-containing protein 4
Authors:Tenthorey, J.L, Haloupek, N, Lopez-Blanco, J.R, Grob, P, Adamson, E, Hartenian, E, Lind, N.A, Bourgeois, N.M, Chacon, P, Nogales, E, Vance, R.E.
Deposit date:2017-09-29
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
Science, 358, 2017
6NPY
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BU of 6npy by Molmil
Cryo-EM structure of NLRP3 bound to NEK7
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ...
Authors:Sharif, H, Wang, L, Wang, W.L, Wu, H.
Deposit date:2019-01-18
Release date:2019-06-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Nature, 570, 2019
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
7ALV
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BU of 7alv by Molmil
Crystal Structure of NLRP3 NACHT domain in complex with a potent inhibitor
Descriptor: 1-[4-chloranyl-2,6-di(propan-2-yl)phenyl]-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
Authors:Dekker, C, Hinniger, A.
Deposit date:2020-10-07
Release date:2021-10-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.835 Å)
Cite:Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.
J.Mol.Biol., 433, 2021
7CRW
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BU of 7crw by Molmil
Cryo-EM structure of rNLRP1-rDPP9 complex
Descriptor: Dipeptidyl peptidase 9, NLR family protein 1
Authors:Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J.
Deposit date:2020-08-14
Release date:2021-03-24
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Nature, 592, 2021
7LFH
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BU of 7lfh by Molmil
Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Andreeva, L, Rawson, S, Wu, H.
Deposit date:2021-01-17
Release date:2021-12-15
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.
Cell, 184, 2021
7PZC
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BU of 7pzc by Molmil
Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3
Descriptor: 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
Authors:Hochheiser, I.V, Pilsl, M, Hagelueken, G, Engel, C, Geyer, M.
Deposit date:2021-10-12
Release date:2022-01-26
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Nature, 604, 2022
7RAV
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BU of 7rav by Molmil
Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1e
Authors:Paidimuddala, B, Cao, J, Xie, Q, Wu, H, Zhang, L.
Deposit date:2021-07-02
Release date:2023-01-11
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5.
Nat.Struct.Mol.Biol., 30, 2023
7VTP
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BU of 7vtp by Molmil
Cryo-EM structure of PYD-deleted human NLRP3 hexamer
Descriptor: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
Authors:Ohto, U, Shimizu, T.
Deposit date:2021-10-30
Release date:2022-03-09
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7VTQ
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BU of 7vtq by Molmil
Cryo-EM structure of mouse NLRP3 (full-length) dodecamer
Descriptor: 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
Authors:Ohto, U, Shimizu, T.
Deposit date:2021-10-30
Release date:2022-03-09
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WBT
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BU of 7wbt by Molmil
Crystal structure of bovine NLRP9
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9
Authors:Kamitsukasa, Y, Shimizu, T, Ohto, U.
Deposit date:2021-12-17
Release date:2022-04-06
Last modified:2022-04-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
7WBU
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BU of 7wbu by Molmil
Cryo-EM structure of bovine NLRP9
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9
Authors:Kamitsukasa, Y, Shimizu, T, Ohto, U.
Deposit date:2021-12-17
Release date:2022-04-06
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
Febs Lett., 596, 2022
7WGE
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BU of 7wge by Molmil
Human NLRP1 complexed with thioredoxin
Descriptor: MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2021-12-28
Release date:2023-07-05
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome.
Nature, 622, 2023
7ZGU
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BU of 7zgu by Molmil
Human NLRP3-deltaPYD hexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3
Authors:Raisch, T, Machtens, D.A, Bresch, I.B, Eberhage, J, Prumbaum, D, Reubold, T.F, Raunser, S, Eschenburg, S.
Deposit date:2022-04-04
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the NEK7-independent NLRP3 inflammasome
To Be Published
8EJ4
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BU of 8ej4 by Molmil
Cryo-EM structure of the active NLRP3 inflammasome disk
Descriptor: MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 3, ...
Authors:Hao, W, Le, X.
Deposit date:2022-09-16
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of the active NLRP3 inflammasome disc.
Nature, 613, 2023
8ETR
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BU of 8etr by Molmil
CryoEM Structure of NLRP3 NACHT domain in complex with G2394
Descriptor: (6S,8R)-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Murray, J.M, Johnson, M.C.
Deposit date:2022-10-17
Release date:2022-11-02
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J.Med.Chem., 65, 2022
8FML
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BU of 8fml by Molmil
Cryo-EM structure of NLR family apoptosis inhibitory protein 5 (NAIP5) in complex with a full-length flagellin (FliC) ligand
Descriptor: Baculoviral IAP repeat-containing protein 1e, Flagellin
Authors:Paidimuddala, B, Zhang, L.
Deposit date:2022-12-23
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structural basis for flagellin-induced NAIP5 activation.
Sci Adv, 9, 2023

 

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