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1S29
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BU of 1s29 by Molmil
La autoantigen N-terminal domain
Descriptor: La protein
Authors:Dong, G, Chakshusmathi, G, Wolin, S.L, Reinisch, K.M.
Deposit date:2004-01-08
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.
Embo J., 23, 2004
1S7A
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BU of 1s7a by Molmil
NMR structure of the La motif of human La protein
Descriptor: Lupus La protein
Authors:Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R.
Deposit date:2004-01-29
Release date:2004-04-06
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
1YTY
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BU of 1yty by Molmil
Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
Descriptor: 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein
Authors:Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J.
Deposit date:2005-02-11
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen.
Mol.Cell, 21, 2006
1ZH5
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BU of 1zh5 by Molmil
Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
Descriptor: 5'-R(*UP*GP*CP*UP*GP*UP*UP*UP*U)-3', Lupus La protein, SULFATE ION
Authors:Teplova, M, Yuan, Y.R, Ilin, S, Malinina, L, Phan, A.T, Teplov, A, Patel, D.J.
Deposit date:2005-04-22
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Recognition and Sequestration of UUU(OH) 3' Temini of Nascent RNA Polymerase III Transcripts by La, a Rheumatic Disease Autoantigen.
Mol.Cell, 21, 2006
2CQK
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BU of 2cqk by Molmil
Solution structure of the La domain of c-Mpl binding protein
Descriptor: C-Mpl binding protein
Authors:Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-20
Release date:2005-11-20
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the La domain of c-Mpl binding protein
To be Published
2M5W
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BU of 2m5w by Molmil
NMR Solution Structure of the La motif (N-terminal Domain, NTD) of Dictyostelium discoideum La protein
Descriptor: Lupus La protein
Authors:Vourtsis, D.J, Chasapis, C.T, Apostolidi, M, Stathopoulos, C, Bentrop, D, Spyroulias, G.A.
Deposit date:2013-03-11
Release date:2014-03-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR Solution Structure of the La motif (N-terminal Domain, NTD) of Dictyostelium discoideum La protein
To be Published
2MTF
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BU of 2mtf by Molmil
Solution structure of the La motif of human LARP6
Descriptor: La-related protein 6
Authors:Martino, L, Salisbury, N.JH, Atkinson, A.R, Kelly, G, Conte, M.R.
Deposit date:2014-08-18
Release date:2014-12-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
2VOD
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BU of 2vod by Molmil
Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU
Descriptor: 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN
Authors:Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S.
Deposit date:2008-02-15
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VON
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BU of 2von by Molmil
Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU
Descriptor: 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3', LUPUS LA PROTEIN
Authors:Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VOO
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Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU
Descriptor: 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN
Authors:Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
2VOP
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BU of 2vop by Molmil
Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU
Descriptor: 5'-R(*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN, SULFATE ION
Authors:Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S.
Deposit date:2008-02-19
Release date:2008-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
4WKR
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BU of 4wkr by Molmil
LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332)
Descriptor: 7SK GGHP4 (300-332), La-related protein 7
Authors:Uchikawa, E, Natchiar, K.S, Han, X, Proux, F, Roblin, P, Zhang, E, Durand, A, Klaholz, B.P, Dock-Bregeon, A.-C.
Deposit date:2014-10-03
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Nucleic Acids Res., 43, 2015
6D6V
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BU of 6d6v by Molmil
CryoEM structure of Tetrahymena telomerase with telomeric DNA at 4.8 Angstrom resolution
Descriptor: DNA (5'-D(P*GP*TP*TP*GP*GP*GP*GP*TP*TP*GP*GP*GP*GP*TP*TP*GP*GP*GP*G)-3'), RNA (159-MER), Telomerase associated protein p65, ...
Authors:Jiang, J, Wang, Y, Susac, L, Chan, H, Basu, R, Zhou, Z.H, Feigon, J.
Deposit date:2018-04-22
Release date:2018-05-30
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of Telomerase with Telomeric DNA.
Cell, 173, 2018
6I9B
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BU of 6i9b by Molmil
NMR structure of the La module from human LARP4A
Descriptor: La-related protein 4
Authors:Conte, M.R, Martino, L, Atkinson, R.A, Kelly, G, Cruz-Gallardo, I, De Tito, S, Trotta, R.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Nucleic Acids Res., 47, 2019
7LMA
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BU of 7lma by Molmil
Tetrahymena telomerase T3D2 structure at 3.3 Angstrom
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J.
Deposit date:2021-02-05
Release date:2021-05-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of telomerase at several steps of telomere repeat synthesis.
Nature, 593, 2021
7LMB
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BU of 7lmb by Molmil
Tetrahymena telomerase T5D5 structure at 3.8 Angstrom
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:He, Y, Wang, Y, Liu, B, Helmling, C, Susac, L, Cheng, R, Zhou, Z.H, Feigon, J.
Deposit date:2021-02-05
Release date:2021-05-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of telomerase at several steps of telomere repeat synthesis.
Nature, 593, 2021
7SLP
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BU of 7slp by Molmil
Cryo-EM structure of 7SK core RNP with linear RNA
Descriptor: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Linear 7SK RNA, ...
Authors:Yang, Y, Liu, S, Zhou, Z.H, Feigon, J.
Deposit date:2021-10-24
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP.
Mol.Cell, 82, 2022
7SLQ
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BU of 7slq by Molmil
Cryo-EM structure of 7SK core RNP with circular RNA
Descriptor: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Minimal circular 7SK RNA, ...
Authors:Yang, Y, Liu, S, Zhou, Z.H, Feigon, J.
Deposit date:2021-10-24
Release date:2022-03-30
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP.
Mol.Cell, 82, 2022
7SOW
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BU of 7sow by Molmil
LaM domain of human LARP1 in complex with UUUUUU
Descriptor: 1,2-ETHANEDIOL, Isoform 2 of La-related protein 1, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3')
Authors:Kozlov, G, Gehring, K.
Deposit date:2021-11-01
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis of 3'-end RNA recognition by LARP1
To Be Published
7UY5
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BU of 7uy5 by Molmil
Tetrahymena telomerase with CST
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
Deposit date:2022-05-06
Release date:2022-07-13
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
7UY6
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BU of 7uy6 by Molmil
Tetrahymena telomerase at 2.9 Angstrom resolution
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:He, Y, Song, H, Chan, H, Wang, Y, Liu, B, Susac, L, Zhou, Z.H, Feigon, J.
Deposit date:2022-05-06
Release date:2022-07-13
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Nature, 608, 2022
8GAP
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BU of 8gap by Molmil
Structure of LARP7 protein p65-telomerase RNA complex in telomerase
Descriptor: Telomerase La-related protein p65, Telomerase RNA, Telomerase associated protein p50, ...
Authors:Wang, Y, He, Y, Wang, Y, Yang, Y, Singh, M, Eichhorn, C.D, Zhou, Z.H, Feigon, J.
Deposit date:2023-02-23
Release date:2023-06-28
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.
J.Mol.Biol., 435, 2023

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PDB entries from 2024-03-27

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