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1B3R
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BU of 1b3r by Molmil
RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE)
Authors:Hu, Y, Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M.
Deposit date:1998-12-14
Release date:1998-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry, 38, 1999
1D4F
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CRYSTAL STRUCTURE OF RECOMBINANT RAT-LIVER D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor: ADENOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYLHOMOCYSTEINE HYDROLASE
Authors:Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M.
Deposit date:2000-06-22
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
J.Biol.Chem., 275, 2000
1A7A
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STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH
Descriptor: (1'R,2'S)-9-(2-HYDROXY-3'-KETO-CYCLOPENTEN-1-YL)ADENINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYLHOMOCYSTEINE HYDROLASE
Authors:Turner, M.A, Yuan, C.-S, Borchardt, R.T, Hershfield, M.S, Smith, G.D, Howell, P.L.
Deposit date:1998-03-10
Release date:1999-04-20
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Nat.Struct.Biol., 5, 1998
5HM8
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2.85 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Adenosine and NAD.
Descriptor: ADENOSINE, Adenosylhomocysteinase, CHLORIDE ION, ...
Authors:Minasov, G, Shuvalova, L, Halavaty, A, Kiryukhina, O, Dubrovska, I, Bishop, B, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-01-15
Release date:2016-01-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:2.85 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Adenosine and NAD.
To Be Published
2H5L
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S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine
Descriptor: (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yamada, T, Komoto, J, Takusagawa, F.
Deposit date:2006-05-26
Release date:2007-04-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochem.Pharm., 73, 2007
6UK3
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Crystal Structure of S-adenosyl-L-homocysteine hydrolase from Acanthamoeba castellanii with bound NAD and Adenosine
Descriptor: ACETATE ION, ADENOSINE, Adenosylhomocysteinase, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-04
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of S-adenosyl-L-homocysteine hydrolase from Acanthamoeba castellanii with bound NAD and Adenosine
to be published
6APH
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BU of 6aph by Molmil
Crystal structure of Adenosylhomocysteinase from Elizabethkingia anophelis NUHP1 in complex with NAD and Adenosine
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE, Adenosylhomocysteinase, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-17
Release date:2017-08-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of Adenosylhomocysteinase from Elizabethkingia anophelis NUHP1 in complex with NAD and Adenosine
To be Published
7O5L
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Crystal structure of S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803 cocrystallized with adenosine in the presence of Rb+ cations
Descriptor: ADENOSINE, Adenosylhomocysteinase, CHLORIDE ION, ...
Authors:Malecki, P.H, Imiolczyk, B, Barciszewski, J, Czyrko-Horczak, J, Brzezinski, K.
Deposit date:2021-04-08
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
Acta Crystallogr D Struct Biol, 78, 2022
7O5M
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Crystal structure of S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803 cocrystallized with adenosine in the presence of Na+ cations
Descriptor: ADENOSINE, Adenosylhomocysteinase, CHLORIDE ION, ...
Authors:Malecki, P.H, Imiolczyk, B, Barciszewski, J, Czyrko-Horczak, J, Brzezinski, K.
Deposit date:2021-04-08
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
Acta Crystallogr D Struct Biol, 78, 2022
4YVF
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Structure of S-adenosyl-L-homocysteine hydrolase
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{[5-chloro-2-(4-chlorophenoxy)phenyl](2-{[2-(methylamino)ethyl]amino}-2-oxoethyl)amino}-N-(1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide, Adenosylhomocysteinase
Authors:Akiko, K.
Deposit date:2015-03-20
Release date:2015-11-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
Bioorg.Med.Chem., 23, 2015
1V8B
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Crystal structure of a hydrolase
Descriptor: ADENOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, adenosylhomocysteinase
Authors:Tanaka, N, Nakanishi, M, Kusakabe, Y, Shiraiwa, K, Kitade, Y, Nakamura, K.T.
Deposit date:2004-01-03
Release date:2004-10-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of S-Adenosyl-l-Homocysteine Hydrolase from the Human Malaria Parasite Plasmodium falciparum
J.Mol.Biol., 343, 2004
5AXD
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Crystal structure of mouse SAHH complexed with ribavirin
Descriptor: 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kusakabe, Y, Ishihara, M, Tanaka, N.
Deposit date:2015-07-24
Release date:2016-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of mouse SAHH complexed with ribavirin
To Be Published
1XWF
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K185N mutated S-adenosylhomocysteine hydrolase
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yamada, T, Takata, Y, Komoto, J, Gomi, T, Ogawa, H, Fujioka, M, Takusagawa, F.
Deposit date:2004-11-01
Release date:2005-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of S-adenosylhomocysteine hydrolase: Roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Int.J.Biochem.Cell Biol., 37, 2005
3X2E
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A thermophilic hydrolase
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Adenosylhomocysteinase
Authors:Zheng, Y, Ko, T.P, Huang, C.H.
Deposit date:2014-12-21
Release date:2015-05-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima.
J.Struct.Biol., 190, 2015
3X2F
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A Thermophilic S-Adenosylhomocysteine Hydrolase
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Adenosylhomocysteinase, NITRATE ION, ...
Authors:Zheng, Y, Ko, T.P, Huang, C.H.
Deposit date:2014-12-21
Release date:2015-05-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima.
J.Struct.Biol., 190, 2015
5AXB
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Crystal structure of mouse SAHH complexed with noraristeromycin
Descriptor: (1S,2R,3S,4R)-4-(6-aminopurin-9-yl)cyclopentane-1,2,3-triol, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kusakabe, Y, Ishihara, M, Tanaka, N.
Deposit date:2015-07-24
Release date:2016-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of mouse SAHH complexed with noraristeromycin
To Be Published
5AXA
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Crystal structure of mouse SAHH complexed with adenosine
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kusakabe, Y, Ishihara, M, Tanaka, N.
Deposit date:2015-07-24
Release date:2016-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of mouse SAHH complexed with adenosine
To Be Published
5AXC
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Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin
Descriptor: (2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-2-hydroxy-5-(hydroxymethyl)cyclopentanone, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kusakabe, Y, Ishihara, M, Tanaka, N.
Deposit date:2015-07-24
Release date:2016-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin
To Be Published
4LVC
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Crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii in complex with adenosine
Descriptor: ACETATE ION, ADENOSINE, AMMONIUM ION, ...
Authors:Manszewski, T, Singh, K, Imiolczyk, B, Jaskolski, M.
Deposit date:2013-07-26
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii.
Acta Crystallogr.,Sect.D, 71, 2015
3CE6
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Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and adenosine
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C.
Deposit date:2008-02-28
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3D64
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Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei
Descriptor: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-05-18
Release date:2008-06-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei.
To be Published
3DHY
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Crystal Structures of Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase in Ternary Complex with Substrate and Inhibitors
Descriptor: 5'-S-ethyl-5'-thioadenosine, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shetty, N.D, Ioerger, T.R, Gokulan, K, Reddy, M.C.M, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-06-19
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
2ZJ0
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Crystal structure of Mycobacterium tuberculosis S-Adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 2-fluoroadenosine
Descriptor: 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C.
Deposit date:2008-02-29
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
2ZJ1
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Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3'-keto-aristeromycin
Descriptor: (2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-2-hydroxy-5-(hydroxymethyl)cyclopentanone, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C.
Deposit date:2008-02-29
Release date:2008-09-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
4PFJ
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The structure of bi-acetylated SAHH
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J.
Deposit date:2014-04-29
Release date:2014-10-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014

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