6DV9
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX(ECF SIGMA FACTOR L) CONTAINING 5NT RNA WITH 4NT SPACER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W., Das, K., Feng, Y., Ebright, R.H.
Deposit date:2018-06-23
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis of ECF-sigma-factor-dependent transcription initiation.
Nat Commun, 10, 2019
6DVB
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX(ECF SIGMA FACTOR L) CONTAINING 5NT RNA WITH 5NT SPACER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W., Das, K., Feng, Y., Ebright, R.H.
Deposit date:2018-06-23
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis of ECF-sigma-factor-dependent transcription initiation.
Nat Commun, 10, 2019
6DVC
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX(ECF SIGMA FACTOR L) CONTAINING 5NT RNA WITH 6NT SPACER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W., Das, K., Feng, Y., Ebright, R.H.
Deposit date:2018-06-23
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of ECF-sigma-factor-dependent transcription initiation.
Nat Commun, 10, 2019
6DVD
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX(ECF SIGMA FACTOR L) WITH 6 NT SPACER AND BROMINE LABELLED IN POSITION "-11
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W., Das, K., Feng, Y., Ebright, R.H.
Deposit date:2018-06-23
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.899 Å)
Cite:Structural basis of ECF-sigma-factor-dependent transcription initiation.
Nat Commun, 10, 2019
6DVE
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX(ECF SELENOMETHIONINE-LABELLED SIGMA FACTOR L) WITH 6 NT SPACER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W., Das, K., Feng, Y., Ebright, R.H.
Deposit date:2018-06-23
Release date:2019-02-20
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.812 Å)
Cite:Structural basis of ECF-sigma-factor-dependent transcription initiation.
Nat Commun, 10, 2019
6N60
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ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME BOUND TO UPSTREAM FORK PROMOTER DNA AND MICROCIN J25 (MCCJ25)
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N., Hauver, J., Campbell, E.A., Darst, S.A.
Deposit date:2018-11-23
Release date:2019-01-09
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.68 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N61
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ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME BOUND TO UPSTREAM FORK PROMOTER DNA AND CAPISTRUIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N., Hauver, J., Campbell, E.A., Darst, S.A.
Deposit date:2018-11-24
Release date:2019-01-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (3.253 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N62
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ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME BOUND TO UPSTREAM FORK PROMOTER DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N., Hauver, J., Campbell, E.A., Darst, S.A.
Deposit date:2018-11-24
Release date:2019-01-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (3.803 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6EYD
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STRUCTURE OF MYCOBACTERIUM SMEGMATIS RNA POLYMERASE SIGMA-A HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Kouba, T., Barvik, I., Krasny, L.
Deposit date:2017-11-11
Release date:2018-12-12
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis.
J. Bacteriol., 201, 2019
6EDT
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MYCOBACTERIUM TUBERCULOSIS RNAP OPEN PROMOTER COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-10
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EE8
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EEC
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER CAPTURED BY CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6M7J
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MYCOBACTERIUM TUBERCULOSIS RNAP WITH RBPA/US FORK AND CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-20
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6DCF
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH RIFAMPICIN-RESISTANT RNA POLYMERASE AND BOUND TO KANGLEMYCIN A
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-05-06
Release date:2018-09-05
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
6CCE
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR KANGLEMYCIN A
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
6CCV
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR RIFAMPICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nat Commun, 9, 2018
6CUU
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THERMUS THERMOPHILES RNA POLYMERASE IN COMPLEX WITH PROMOTER DNA AND ANTIBIOTIC KANGLEMYCIN A
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V., Murakami, K.S.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
6CUX
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ESCHERICHIA COLI RPOB S531L MUTANT RNA POLYMERASE HOLOENZYME IN COMPLEX WITH KANGLEMYCIN A
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V., Murakami, K.S.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (4.104 Å)
Cite:Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
5OR5
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NMR STRUCTURE OF THE COMPLEX FORMED BY AN ENGINEERED REGION 2 OF SIGMAE IN COMPLEX WITH GTAAAA
Descriptor:ECF RNA polymerase sigma-E factor,ECF RNA polymerase sigma factor SigW,ECF RNA polymerase sigma-E factor, DNA (5'-D(*GP*TP*AP*AP*AP*A)-3')
Authors:Campagne, S., Vorholt, J.A., Allain, F.H.
Deposit date:2017-08-15
Release date:2018-06-27
Method:SOLUTION NMR
Cite:Engineered promoter selectivity of an ECF sigma factor
To be published
6BZO
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MTB RNAP HOLO/RBPA/FIDAXOMICIN/UPSTREAM FORK DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C04
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MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C06
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
5UXX
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CO-CRYSTAL STRUCTURE OF THE SIGMA FACTOR RPOE IN COMPLEX WITH THE ANTI-SIGMA FACTOR NEPR FROM BARTONELLA QUINTANA
Descriptor:RNA polymerase sigma factor, Anti-sigma factor NepR, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-02-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Co-crystal structure of the sigma factor RpoE in complex with the anti-sigma factor NepR from Bartonella quintana
to be published
6C9Y
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CRYO-EM STRUCTURE OF E. COLI RNAP SIGMA70 HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Narayanan, A., Vago, F., Li, K., Qayyum, M.Z., Yenool, D., Jiang, W., Murakami, K.S.
Deposit date:2018-01-29
Release date:2018-02-28
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018