PDB: 31 resultsInfo pagesStatus searchChemie searchBIRD

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7TJK	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJJ	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJH	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJI	S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7TJF	S. cerevisiae ORC bound to 84 bp ARS1 DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ... Authors: Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. Deposit date: 2022-01-16 Release date: 2023-01-18 Last modified: 2023-02-22 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
7MCA	Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA. Descriptor: Cell division control protein 6, DNA (85-MER), MAGNESIUM ION, ... Authors: Feng, X, Li, H. Deposit date: 2021-04-01 Release date: 2021-06-02 Last modified: 2021-08-04 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nat Commun, 12, 2021
7CTF	Human origin recognition complex 1-5 State II Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... Authors: Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. Deposit date: 2020-08-18 Release date: 2021-01-06 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
7CTE	Human Origin Recognition Complex, ORC2-5 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ... Authors: Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. Deposit date: 2020-08-18 Release date: 2021-01-06 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
7CTG	Human Origin Recognition Complex, ORC1-5 State I Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... Authors: Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. Deposit date: 2020-08-18 Release date: 2021-01-06 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
7JPP	ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPR	ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPQ	ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 2, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPO	ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPS	ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2022-10-26 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JK4	Structure of Drosophila ORC bound to AT-rich DNA and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (34-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK6	Structure of Drosophila ORC in the active conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK2	Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 1) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK3	Structure of Drosophila ORC bound to GC-rich DNA and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JK5	Structure of Drosophila ORC bound to DNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (32-MER), MAGNESIUM ION, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-27 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JGS	Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 2) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-19 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
7JGR	Structure of Drosophila ORC bound to DNA (84 bp) and Cdc6 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ... Authors: Schmidt, J.M, Bleichert, F. Deposit date: 2020-07-19 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
6WGI	Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... Authors: Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. Deposit date: 2020-04-05 Release date: 2020-07-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (10 Å) Cite: Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
6WGG	Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) Descriptor: Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... Authors: Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. Deposit date: 2020-04-05 Release date: 2020-07-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (8.1 Å) Cite: Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
6WGC	Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) Descriptor: Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... Authors: Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. Deposit date: 2020-04-05 Release date: 2020-07-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
6RQC	Cryo-EM structure of an MCM loading intermediate Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... Authors: Miller, T.C.R, Locke, J, Costa, A. Deposit date: 2019-05-15 Release date: 2019-11-20 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature, 575, 2019

 

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