7TFC
| B. subtilis GS(14)-Q-GlnR peptide | Descriptor: | GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ... | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (1.96 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
|
|
7TDP
| |
4ACF
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE. | Descriptor: | CHLORIDE ION, GLUTAMINE SYNTHETASE 1, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ... | Authors: | Nilsson, M.T, Mowbray, S.L. | Deposit date: | 2011-12-15 | Release date: | 2012-10-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors Medchemcomm, 3, 2012
|
|
8ECY
| cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex | Descriptor: | Bestrophin, CALCIUM ION, CHLORIDE ION, ... | Authors: | Owji, A.P, Kittredge, A.K, Yang, T. | Deposit date: | 2022-09-02 | Release date: | 2022-11-02 | Last modified: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Bestrophin-2 and glutamine synthetase form a complex for glutamate release. Nature, 611, 2022
|
|
2OJW
| Crystal structure of human glutamine synthetase in complex with ADP and phosphate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | Authors: | Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | Deposit date: | 2007-01-15 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J.Mol.Biol., 375, 2008
|
|
7TFA
| P. polymyxa GS(12)-Q-GlnR peptide | Descriptor: | GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ... | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.07 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
|
|
2BVC
| Crystal structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... | Authors: | Krajewski, W.W, Jones, T.A, Mowbray, S.L. | Deposit date: | 2005-06-23 | Release date: | 2005-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights. Proc.Natl.Acad.Sci.USA, 102, 2005
|
|
7TF7
| S. aureus GS(12) - apo | Descriptor: | Glutamine synthetase | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.13 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
|
|
3ZXR
| |
7TF6
| S. aureus GS(12)-Q-GlnR peptide | Descriptor: | GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ... | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.15 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
|
|
2WHI
| Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate. | Descriptor: | 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... | Authors: | Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L. | Deposit date: | 2009-05-05 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. J.Mol.Biol., 393, 2009
|
|
3ZXV
| |
7TFB
| P. polymyxa GS(14)-Q-GlnR peptide | Descriptor: | GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ... | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.28 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
|
|
8TGE
| |
4S17
| The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703 | Descriptor: | ACETATE ION, Glutamine synthetase, MAGNESIUM ION | Authors: | Cuff, M, Tan, K, Mack, J, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-01-08 | Release date: | 2015-01-28 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703 To be Published
|
|
4IS4
| |
1HTO
| |
1HTQ
| Multicopy crystallographic structure of a relaxed glutamine synthetase from Mycobacterium tuberculosis | Descriptor: | ADENOSINE MONOPHOSPHATE, CITRIC ACID, MANGANESE (II) ION, ... | Authors: | Gill, H.S, Pfluegl, G.M, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2001-01-01 | Release date: | 2002-07-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry, 41, 2002
|
|
8UFJ
| Structure of M. mazei GS(R167L-A168G) apo form | Descriptor: | Glutamine synthetase, MAGNESIUM ION | Authors: | Schumacher, M.A. | Deposit date: | 2023-10-04 | Release date: | 2023-11-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation. Nat Commun, 14, 2023
|
|
1F52
| CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SALMONELLA TYPHIMURIUM CO-CRYSTALLIZED WITH ADP | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLUTAMINE SYNTHETASE, ... | Authors: | Gill, H.S, Pfluegl, G.M.U, Eisenberg, D. | Deposit date: | 2000-06-12 | Release date: | 2000-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition. Biochemistry, 40, 2001
|
|
2WGS
| Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor. | Descriptor: | 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1 | Authors: | Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L. | Deposit date: | 2009-04-27 | Release date: | 2009-09-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors. J.Mol.Biol., 393, 2009
|
|
4BAX
| |
4LNI
| B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of the transition state complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ... | Authors: | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | Deposit date: | 2013-07-11 | Release date: | 2013-11-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5793 Å) | Cite: | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism. J.Biol.Chem., 288, 2013
|
|
7U5N
| |
2QC8
| Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamine synthetase, ... | Authors: | Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hogbom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-19 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J.Mol.Biol., 375, 2008
|
|