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8SGH
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BU of 8sgh by Molmil
Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1
Authors:Gonzalez, A, Fung, H.Y.J, Chook, Y.M.
Deposit date:2023-04-12
Release date:2023-06-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Structure, 31, 2023
8HUG
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BU of 8hug by Molmil
F1 in complex with CRM1-Ran-RanBP1
Descriptor: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-23
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:F1 in complex with CRM1-Ran-RanBP1
To Be Published
8HUF
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BU of 8huf by Molmil
B28 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-23
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:B28 in complex with CRM1-Ran-RanBP1
To Be Published
8HQ6
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BU of 8hq6 by Molmil
KL2 in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ...
Authors:Sun, Q, Jian, L.
Deposit date:2022-12-13
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
8HQ5
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BU of 8hq5 by Molmil
G6 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-12-13
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:F1 in complex with CRM1-Ran-RanBP1
To Be Published
8HQ4
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B27 in complex with CRM1-Ran-RanBP1
Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Lei, Y, Sun, Q.
Deposit date:2022-12-13
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:B27 in complex with CRM1-Ran-RanBP1
To Be Published
8HQ3
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BU of 8hq3 by Molmil
KL1 in complex with CRM1-Ran-RanBP1
Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ...
Authors:Sun, Q, Jian, L.
Deposit date:2022-12-13
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
8H5B
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BU of 8h5b by Molmil
The cryo-EM structure of nuclear transport receptor Kap114p complex with yeast TATA-box binding protein
Descriptor: Importin subunit beta-5, TATA-box-binding protein
Authors:Hsia, K.C, Liao, C.C, Wang, C.H, Wu, Y.M.
Deposit date:2022-10-12
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (4.03 Å)
Cite:Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein.
Nat Commun, 14, 2023
8GCN
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BU of 8gcn by Molmil
CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER
Descriptor: Importin subunit alpha-1, Importin subunit beta-1
Authors:Ko, Y, Cingolani, G.
Deposit date:2023-03-02
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER
To Be Published
8F7A
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BU of 8f7a by Molmil
Cryo-EM structure of Importin-9 bound to RanGTP
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ...
Authors:Bernardes, N.E, Chook, Y.M.
Deposit date:2022-11-18
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E
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BU of 8f1e by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ...
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F19
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BU of 8f19 by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP)
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ...
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0X
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BU of 8f0x by Molmil
Cryo-EM structure of Kap114 bound to H2A-H2B
Descriptor: Histone H2A.2, Histone H2B.2, Importin subunit beta-5
Authors:Jiou, J, Chook, Y.M.
Deposit date:2022-11-04
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DYO
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BU of 8dyo by Molmil
Cryo-EM structure of Importin-4 bound to RanGTP
Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ...
Authors:Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M.
Deposit date:2022-08-04
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
7YPZ
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BU of 7ypz by Molmil
Zafirlukast in complex with CRM1-Ran-RanBP1
Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2022-08-05
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.
J.Med.Chem., 66, 2023
7VPW
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BU of 7vpw by Molmil
Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724)
Descriptor: BRCA1-associated protein 1 (BAP1), Transportin-1
Authors:Yang, T.J, Hsu, S.T.D.
Deposit date:2021-10-18
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.76 Å)
Cite:Tumor suppressor BAP1 nuclear import is governed by transportin-1.
J.Cell Biol., 221, 2022
7UNK
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BU of 7unk by Molmil
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
Descriptor: Histone H3, Histone H4, Histone chaperone, ...
Authors:Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y.
Deposit date:2022-04-11
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
7L5E
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BU of 7l5e by Molmil
Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ)
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Baumhardt, J.M, Chook, Y.M.
Deposit date:2020-12-21
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.944 Å)
Cite:Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
7DBG
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BU of 7dbg by Molmil
Yeast CRM1e (apo) in complex with Ran-RanBP1
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-10-20
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
7CYL
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BU of 7cyl by Molmil
Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Chook, Y.M.
Deposit date:2020-09-03
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Sci Rep, 11, 2021
7CND
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BU of 7cnd by Molmil
NCI-1 in complex with CRM1-Ran-RanBP1
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ...
Authors:Sun, Q, Lei, Y.
Deposit date:2020-07-31
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.
J.Med.Chem., 64, 2021
7B51
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BU of 7b51 by Molmil
Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528
Descriptor: BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ...
Authors:Shaikhqasem, A, Ficner, R.
Deposit date:2020-12-03
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP.
Acta Crystallogr.,Sect.F, 77, 2021
6XJU
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BU of 6xju by Molmil
Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
Authors:Baumhardt, J.M, Chook, Y.M.
Deposit date:2020-06-24
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.193 Å)
Cite:Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6XJT
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BU of 6xjt by Molmil
Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)
Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
Authors:Baumhardt, J.M, Chook, Y.M.
Deposit date:2020-06-24
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6XJS
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BU of 6xjs by Molmil
Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
Authors:Baumhardt, J.M, Chook, Y.M.
Deposit date:2020-06-24
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.942 Å)
Cite:Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021

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PDB entries from 2024-03-27

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