1V4S
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CRYSTAL STRUCTURE OF HUMAN GLUCOKINASE
Descriptor:glucokinase isoform 2, ALPHA-D-GLUCOSE, SODIUM ION, ...
Authors:Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., Nagata, Y.
Deposit date:2003-11-19
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
Structure, 12, 2004
1V4T
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CRYSTAL STRUCTURE OF HUMAN GLUCOKINASE
Descriptor:glucokinase isoform 2, SULFATE ION, SODIUM ION
Authors:Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., Nagata, Y.
Deposit date:2003-11-19
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
Structure, 12, 2004
2YHX
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SEQUENCING A PROTEIN BY X-RAY CRYSTALLOGRAPHY. II. REFINEMENT OF YEAST HEXOKINASE B CO-ORDINATES AND SEQUENCE AT 2.1 ANGSTROMS RESOLUTION
Descriptor:HEXOKINASE B, ORTHO-TOLUOYLGLUCOSAMINE
Authors:Steitz, T.A., Anderson, C.M., Stenkamp, R.E.
Deposit date:1978-03-20
Release date:1978-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sequencing a protein by x-ray crystallography. II. Refinement of yeast hexokinase B co-ordinates and sequence at 2.1 A resolution.
J.Mol.Biol., 123, 1978
3A0I
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HUMAN GLUCOKINASE IN COMPLEX WITH A SYNTHETIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide, ...
Authors:Kamata, K., Mitsuya, M.
Deposit date:2009-03-19
Release date:2009-04-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
Bioorg.Med.Chem.Lett., 19, 2009
3FR0
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HUMAN GLUCOKINASE IN COMPLEX WITH 2-AMINO BENZAMIDE ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ...
Authors:Kamata, K.
Deposit date:2009-01-08
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Bioorg.Med.Chem.Lett., 19, 2009
3GOI
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HUMAN GLUCOKINASE IN COMPLEX WITH A SYNTHETIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide
Authors:Kamata, K., Mitsuya, M.
Deposit date:2009-03-19
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
Bioorg.Med.Chem.Lett., 19, 2009
3H1V
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HUMAN GLUCOKINASE IN COMPLEX WITH A SYNTHETIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, ...
Authors:Kamata, K., Takahashi, K.
Deposit date:2009-04-14
Release date:2009-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.
Bioorg.Med.Chem., 17, 2009
3IMX
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CRYSTAL STRUCTURE OF HUMAN GLUCOKINASE IN COMPLEX WITH A SYNTHETIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide, ...
Authors:Stams, T., Vash, B.
Deposit date:2009-08-11
Release date:2009-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.
J.Med.Chem., 52, 2009
3VEY
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GLUCOKINASE IN COMPLEX WITH GLUCOSE AND ATPGS
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, SODIUM ION, ...
Authors:Liu, S.
Deposit date:2012-01-09
Release date:2012-02-08
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
J.Biol.Chem., 287, 2012
4ISE
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL ACTIVATOR (2S)-3-CYCLOHEXYL-2-(6-FLUORO-4-OXOQUINAZOLIN-3(4H)-YL)-N-(1,3-THIAZOL-2-YL)PROPANAMIDE
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide, ...
Authors:Hosfield, D., Skene, R.J.
Deposit date:2013-01-16
Release date:2013-03-20
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Design, synthesis and SAR of novel glucokinase activators.
Bioorg.Med.Chem.Lett., 23, 2013
4ISF
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL ACTIVATOR (2S)-3-CYCLOHEXYL-2-(6-FLUORO-2,4-DIOXO-1,4-DIHYDROQUINAZOLIN-3(2H)-YL)-N-(1,3-THIAZOL-2-YL)PROPANAMIDE
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide, ...
Authors:Hosfield, D., Skene, R.J.
Deposit date:2013-01-16
Release date:2013-03-20
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Design, synthesis and SAR of novel glucokinase activators.
Bioorg.Med.Chem.Lett., 23, 2013
4ISG
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL ACTIVATOR (2S)-3-CYCLOHEXYL-2-[4-(METHYLSULFONYL)-2-OXOPIPERAZIN-1-YL]-N-(1,3-THIAZOL-2-YL)PROPANAMIDE
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide, ...
Authors:Hosfield, D., Skene, R.J.
Deposit date:2013-01-16
Release date:2013-03-20
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:Design, synthesis and SAR of novel glucokinase activators.
Bioorg.Med.Chem.Lett., 23, 2013
4L3Q
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CRYSTAL STRUCTURE OF GLUCOKINASE-ACTIVATOR COMPLEX
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one
Authors:Gajiwala, K.S., Filipski, K.J.
Deposit date:2013-06-06
Release date:2013-07-24
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg.Med.Chem.Lett., 23, 2013
4MLE
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL AMINO THIAZOLE ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
4MLH
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HUMAN GLUCOKINASE IN COMPLEX WITH A NOVEL AMINO THIAZOLE ALLOSTERIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
4RCH
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DISCOVERY OF 2-PYRIDYL UREAS AS GLUCOKINASE ACTIVATORS
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea
Authors:Voegtli, W., Vigers, G.P.A.
Deposit date:2014-09-16
Release date:2014-10-08
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of 2-pyridylureas as glucokinase activators.
J.Med.Chem., 57, 2014
5V4W
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL INDAZOLE ACTIVATOR.
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide, ...
Authors:Skene, R.J., Hosfield, D.J.
Deposit date:2017-03-10
Release date:2017-05-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Bioorg. Med. Chem. Lett., 27, 2017
5V4X
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL PYRAZOLE ACTIVATOR.
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, (2S)-3-cyclohexyl-2-[4-(cyclopentylsulfonyl)-2-oxopyridin-1(2H)-yl]-N-(1,3-thiazol-2-yl)propanamide, ...
Authors:Skene, R.J., Hosfiled, D.J.
Deposit date:2017-03-10
Release date:2017-05-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Bioorg. Med. Chem. Lett., 27, 2017
1BDG
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HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE
Descriptor:HEXOKINASE, ALPHA-D-GLUCOSE, SULFATE ION
Authors:Mulichak, A.M., Garavito, R.M.
Deposit date:1998-05-08
Release date:1999-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5, 1998
1BG3
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RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE
Descriptor:HEXOKINASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Mulichak, A.M., Garavito, R.M.
Deposit date:1998-06-04
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5, 1998
1CZA
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-09-01
Release date:2000-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1DGK
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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE
Descriptor:HEXOKINASE TYPE I, ALPHA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Liu, X., Kirby, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-11-24
Release date:2000-03-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
J.Mol.Biol., 296, 2000
1HKB
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE-6-PHOSPHATE, ...
Authors:Aleshin, A.E., Zeng, C., Burenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
Deposit date:1997-12-01
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure, 6, 1998
1HKC
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RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
Descriptor:D-GLUCOSE 6-PHOSPHOTRANSFERASE, BETA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Aleshin, A.E., Honzatko, R.B.
Deposit date:1998-07-01
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
J.Mol.Biol., 282, 1998
1HKG
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STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS
Descriptor:HEXOKINASE A
Authors:Bennett Jr., W.S., Steitz, T.A.
Deposit date:1980-12-22
Release date:1981-02-26
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural dynamics of yeast hexokinase during catalysis.
Philos.Trans.R.Soc.London,Ser.B, 293, 1981
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