1K25
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PBP2X FROM A HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS PNEUMONIAE CLINICAL ISOLATE
Descriptor:low-affinity PENICILLIN-BINDING PROTEIN 2X
Authors:Dessen, A., Mouz, N., Hopkins, J., Dideberg, O.
Deposit date:2001-09-26
Release date:2001-10-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.
J.Biol.Chem., 276, 2001
1MWR
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STRUCTURE OF SEMET PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R (TRIGONAL FORM) AT 2.45 A RESOLUTION.
Descriptor:penicillin-binding protein 2a, CADMIUM ION, CHLORIDE ION
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWS
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STRUCTURE OF NITROCEFIN ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.00 A RESOLUTION.
Descriptor:penicillin-binding protein 2a, CADMIUM ION, CHLORIDE ION
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWT
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STRUCTURE OF PENICILLIN G ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.45 A RESOLUTION.
Descriptor:PBP2a, CADMIUM ION, CHLORIDE ION, ...
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWU
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STRUCTURE OF METHICILLIN ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.60 A RESOLUTION.
Descriptor:penicillin-binding protein 2a, (2R,4S)-2-[(1R)-1-{[(2,6-dimethoxyphenyl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CADMIUM ION, ...
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1PYY
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DOUBLE MUTANT PBP2X T338A/M339F FROM STREPTOCOCCUS PNEUMONIAE STRAIN R6 AT 2.4 A RESOLUTION
Descriptor:Penicillin-binding protein 2X, SULFATE ION, N-OCTANOYLSUCROSE, ...
Authors:Chesnel, L., Pernot, L., Lemaire, D., Champelovier, D., Croize, J., Dideberg, O., Vernet, T., Zapun, A.
Deposit date:2003-07-09
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains
J.Biol.Chem., 278, 2003
1QME
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor:PENICILLIN-BINDING PROTEIN 2X, SULFATE ION
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Penicillin-Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance.
J.Mol.Biol., 299, 2000
1QMF
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X) ACYL-ENZYME COMPLEX
Descriptor:PENICILLIN-BINDING PROTEIN 2X, 2-[CARBOXY-(2-FURAN-2-YL-2-METHOXYIMINO-ACETYLAMINO)-METHYL]-5-METHYL-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, CEFUROXIME (OCT-3-ENE FORM)
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of the Penicillin Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance
J.Mol.Biol., 299, 2000
1RP5
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PBP2X FROM STREPTOCOCCUS PNEUMONIAE STRAIN 5259 WITH REDUCED SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS
Descriptor:penicillin-binding protein 2x, SULFATE ION
Authors:Pernot, L., Chesnel, L., Legouellec, A., Croize, J., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2003-12-03
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.
J.Biol.Chem., 279, 2004
1VQQ
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STRUCTURE OF PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 1.80 A RESOLUTION.
Descriptor:penicillin-binding protein mecA, low-affinity, CADMIUM ION, ...
Authors:Lim, D., Strynadka, N.C.J.
Deposit date:2004-12-17
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
2WAD
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PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204)
Descriptor:PENICILLIN-BINDING PROTEIN 2B, ZINC ION
Authors:Contreras-Martel, C., Dahout-Gonzalez, C., Dos-Santos-Martins, A., Kotnik, M., Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
2WAE
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PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204)
Descriptor:PENICILLIN-BINDING PROTEIN 2B, ZINC ION
Authors:Contreras-Martel, C., Dahout-Gonzalez, C., Dos-Santos-Martins, A., Kotnik, M., Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
2WAF
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PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN R6)
Descriptor:PENICILLIN-BINDING PROTEIN 2B, CHLORIDE ION
Authors:Contreras-Martel, C., Dahout-Gonzalez, C., Dos-Santos-Martins, A., Kotnik, M., Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
3EQU
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE
Descriptor:Penicillin-binding protein 2, SULFATE ION, GLYCEROL
Authors:Powell, A.J., Deacon, A.M., Nicholas, R.A., Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
3EQV
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE CONTAINING FOUR MUTATIONS ASSOCIATED WITH PENICILLIN RESISTANCE
Descriptor:Penicillin-binding protein 2, SULFATE ION, GLYCEROL
Authors:Powell, A.J., Deacon, A.M., Nicholas, R.A., Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
3OC2
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Penicillin-binding protein 3, CHLORIDE ION
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-09
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
3OCL
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CARBENICILLIN
Descriptor:Penicillin-binding protein 3, CHLORIDE ION, (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ...
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-10
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
3OCN
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFTAZIDIME
Descriptor:penicillin-binding protein 3, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-10
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
3PBN
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CRYSTAL STRUCTURE OF APO PBP3 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Penicillin-binding protein 3
Authors:Han, S.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PBO
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CRYSTAL STRUCTURE OF PBP3 COMPLEXED WITH CEFTAZIDIME
Descriptor:Penicillin-binding protein 3, ACYLATED CEFTAZIDIME
Authors:Han, S.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PBQ
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CRYSTAL STRUCTURE OF PBP3 COMPLEXED WITH IMIPENEM
Descriptor:Penicillin-binding protein 3, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
Authors:Han, S.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PBR
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CRYSTAL STRUCTURE OF PBP3 COMPLEXED WITH MEROPENEM
Descriptor:Penicillin-binding protein 3, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
Authors:Han, S.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PBS
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CRYSTAL STRUCTURE OF PBP3 COMPLEXED WITH AZTREONAM
Descriptor:Penicillin-binding protein 3, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid
Authors:Han, S.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3PBT
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CRYSTAL STRUCTURE OF PBP3 COMPLEXED WITH MC-1
Descriptor:Penicillin-binding protein 3, (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-4-formyl-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oate
Authors:Han, S., Evdokimov, A.
Deposit date:2010-10-20
Release date:2010-12-22
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (1.641 Å)
Cite:Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 107, 2010
3UE3
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CRYSTAL STRUCTURE OF ACINETOBACTER BAUMANNI PBP3
Descriptor:Septum formation, penicillin binding protein 3, peptidoglycan synthetase
Authors:Han, S.
Deposit date:2011-10-28
Release date:2011-12-14
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics
J.Am.Chem.Soc., 133, 2011
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