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3BJ4
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BU of 3bj4 by Molmil
The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction
Descriptor: NICKEL (II) ION, Potassium voltage-gated channel subfamily KQT member 1
Authors:Wiener, R, Hirsch, J.A.
Deposit date:2007-12-03
Release date:2008-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction.
J.Biol.Chem., 283, 2008
4GOW
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BU of 4gow by Molmil
Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex
Descriptor: CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 4
Authors:Xu, Q, Chang, A, Tolia, A, Minor Jr, D.L.
Deposit date:2012-08-20
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.
J.Mol.Biol., 425, 2013
5VMS
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BU of 5vms by Molmil
CryoEM structure of Xenopus KCNQ1 channel
Descriptor: CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mackinnon, R, Sun, J.
Deposit date:2017-04-28
Release date:2017-06-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
Cell, 169, 2017
7CR4
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BU of 7cr4 by Molmil
human KCNQ2-CaM in complex with ztz240
Descriptor: Calmodulin-3, N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2
Authors:Li, X, Lv, D, Wang, J, Ye, S, Guo, J.
Deposit date:2020-08-12
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
7CR1
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BU of 7cr1 by Molmil
human KCNQ2 in complex with ztz240
Descriptor: N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2
Authors:Li, X, Lv, D, Wang, J, Ye, S, Guo, J.
Deposit date:2020-08-12
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
7TCI
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BU of 7tci by Molmil
Structure of Xenopus KCNQ1-CaM in complex with ML277
Descriptor: (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, CALCIUM ION, Calmodulin-1, ...
Authors:Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D.
Deposit date:2021-12-23
Release date:2022-07-06
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
7TCP
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BU of 7tcp by Molmil
Structure of Xenopus KCNQ1-CaM
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Willegems, K, Kyriakis, E, Van Petegem, F, Eldstrom, J, Fedida, D.
Deposit date:2021-12-27
Release date:2022-07-06
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Nat Commun, 13, 2022
6V00
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BU of 6v00 by Molmil
structure of human KCNQ1-KCNE3-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6UZZ
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BU of 6uzz by Molmil
structure of human KCNQ1-CaM complex
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-16
Release date:2019-12-04
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
6V01
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BU of 6v01 by Molmil
structure of human KCNQ1-KCNE3-CaM complex with PIP2
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily E member 3, ...
Authors:Mackinnon, R, Sun, J.
Deposit date:2019-11-18
Release date:2019-12-04
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
8X43
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BU of 8x43 by Molmil
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Descriptor: Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2
Authors:Ma, D, Guo, J.
Deposit date:2023-11-15
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Nat.Chem.Biol., 2024
8SIK
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BU of 8sik by Molmil
KCNQ1 with voltage sensor in the up conformation
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mandala, V.S, MacKinnon, R.
Deposit date:2023-04-16
Release date:2023-05-31
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
8SIM
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BU of 8sim by Molmil
KCNQ1 with voltage sensor in the intermediate conformation
Descriptor: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mandala, V.S, MacKinnon, R.
Deposit date:2023-04-16
Release date:2023-05-31
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
8SIN
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BU of 8sin by Molmil
KCNQ1 with voltage sensor in the down conformation
Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1
Authors:Mandala, V.S, MacKinnon, R.
Deposit date:2023-04-16
Release date:2023-05-31
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
8W4U
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BU of 8w4u by Molmil
human KCNQ2-CaM in complex with PIP2 and HN37
Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
Authors:Ma, D, Li, X, Guo, J.
Deposit date:2023-08-25
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
7VNR
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BU of 7vnr by Molmil
Structure of human KCNQ4-ML213 complex in digitonin
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7VNP
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BU of 7vnp by Molmil
Structure of human KCNQ4-ML213 complex with PIP2
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7VNQ
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BU of 7vnq by Molmil
Structure of human KCNQ4-ML213 complex in nanodisc
Descriptor: (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid, Calmodulin-3, POTASSIUM ION, ...
Authors:Xu, F, Zheng, Y.
Deposit date:2021-10-11
Release date:2021-12-01
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
Neuron, 110, 2022
7BYM
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BU of 7bym by Molmil
Cryo-EM structure of human KCNQ4 with retigabine
Descriptor: Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ...
Authors:Shen, H, Li, T, Yue, Z.
Deposit date:2020-04-23
Release date:2020-12-02
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
7BYL
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BU of 7byl by Molmil
Cryo-EM structure of human KCNQ4
Descriptor: Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ...
Authors:Shen, H, Li, T, Yue, Z.
Deposit date:2020-04-23
Release date:2020-12-02
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
7BYN
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BU of 7byn by Molmil
Cryo-EM structure of human KCNQ4 with linopirdine
Descriptor: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one, Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, ...
Authors:Shen, H, Li, T, Yue, Z.
Deposit date:2020-04-23
Release date:2020-12-02
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
7CR2
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BU of 7cr2 by Molmil
human KCNQ2 in complex with retigabine
Descriptor: Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Authors:Li, X, Lv, D, Wang, J, Ye, S, Guo, J.
Deposit date:2020-08-12
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
7CR7
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BU of 7cr7 by Molmil
human KCNQ2-CaM in complex with retigabine
Descriptor: Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Authors:Li, X, Lv, D, Wang, J, Ye, S, Guo, J.
Deposit date:2020-08-12
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
7CR0
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BU of 7cr0 by Molmil
human KCNQ2 in apo state
Descriptor: Potassium voltage-gated channel subfamily KQT member 2
Authors:Li, X, Lv, D, Wang, J, Ye, S, Guo, J.
Deposit date:2020-08-12
Release date:2020-09-16
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
7XNL
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BU of 7xnl by Molmil
human KCNQ1-CaM-ML277-PIP2 complex in state A
Descriptor: (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, Calmodulin-3, POTASSIUM ION, ...
Authors:Ma, D, Guo, J.
Deposit date:2022-04-29
Release date:2022-12-14
Last modified:2023-02-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.
Proc.Natl.Acad.Sci.USA, 119, 2022

 

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