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1PYS
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BU of 1pys by Molmil
PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS
Descriptor: MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE
Authors:Safro, M, Mosyak, L, Goldgur, Y, Reshetnikova, L, Delarue, M.
Deposit date:1996-11-14
Release date:1997-11-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
Nat.Struct.Biol., 2, 1995
1B7Y
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PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINYL-ADENYLATE
Descriptor: ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PROTEIN (PHENYLALANYL-TRNA SYNTHETASE)
Authors:Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G.
Deposit date:1999-01-26
Release date:2000-01-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue.
J.Mol.Biol., 287, 1999
1B70
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PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINE
Descriptor: MAGNESIUM ION, PHENYLALANINE, PHENYLALANYL-TRNA SYNTHETASE
Authors:Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G.
Deposit date:1999-01-26
Release date:2000-02-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue
J.Mol.Biol., 287, 1999
1EIY
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THE CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH COGNATE TRNAPHE
Descriptor: PHENYLALANYL-TRNA SYNTHETASE, TRNA(PHE)
Authors:Goldgur, Y, Mosyak, L, Reshetnikova, L, Ankilova, V, Safro, M.
Deposit date:2000-02-29
Release date:2000-03-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
Structure, 5, 1997
1JJC
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Crystal structure at 2.6A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese
Descriptor: ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MANGANESE (II) ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ...
Authors:Safro, M.G, Fishman, R, Moor, N, Ankilova, V.
Deposit date:2001-07-04
Release date:2001-11-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese.
Acta Crystallogr.,Sect.D, 57, 2001
2AKW
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BU of 2akw by Molmil
Crystal Structure of T.Thermophilus Phenylalanyl-tRNA synthetase complexed with p-Cl-Phenylalanine
Descriptor: 4-CHLORO-L-PHENYLALANINE, MANGANESE (II) ION, Phenylalanyl-tRNA synthetase alpha chain, ...
Authors:Kotik-Kogan, O.M, Moor, N.A, Tworowski, D.E, Safro, M.G.
Deposit date:2005-08-04
Release date:2005-12-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
2ALY
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BU of 2aly by Molmil
Crystal Structure of T.Thermophilus Phenylalanyl-tRNA synthetase complexed with 5'-O-[N-(L-tyrosyl)sulphamoyl]adenosine
Descriptor: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, MANGANESE (II) ION, Phenylalanyl-tRNA synthetase alpha chain, ...
Authors:Kotik-Kogan, O.M, Moor, N.A, Tworowski, D.E, Safro, M.G.
Deposit date:2005-08-04
Release date:2005-12-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
2AMC
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Crystal structure of Phenylalanyl-tRNA synthetase complexed with L-tyrosine
Descriptor: MAGNESIUM ION, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
Authors:Kotik-Kogan, O, Moor, N, Tworowski, D, Safro, M.
Deposit date:2005-08-09
Release date:2005-12-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
2IY5
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PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog
Descriptor: ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ...
Authors:Moor, N, Kotik-Kogan, O, Tworowski, D, Sukhanova, M, Safro, M.
Deposit date:2006-07-12
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.
Biochemistry, 45, 2006
2RHS
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PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
Descriptor: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
Authors:Evdokimov, A.G, Mekel, M.
Deposit date:2007-10-09
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2RHQ
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PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
Descriptor: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
Authors:Evdokimov, A.G, Mekel, M.
Deposit date:2007-10-09
Release date:2007-11-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
3CMQ
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BU of 3cmq by Molmil
Crystal structure of human mitochondrial phenylalanine tRNA synthetase
Descriptor: ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MAGNESIUM ION, Phenylalanyl-tRNA synthetase, ...
Authors:Klipcan, L, Levin, I.L, Kessler, N, Moor, N, Finarov, I, Safro, M.
Deposit date:2008-03-24
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The tRNA-Induced Conformational Activation of Human Mitochondrial Phenylalanyl-tRNA Synthetase.
Structure, 16, 2008
3HFV
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Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine
Descriptor: META-TYROSINE, Phenylalanyl-tRNA synthetase, mitochondrial
Authors:Klipcan, L, Moor, N, Kessler, N, Safro, M.G.
Deposit date:2009-05-12
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine
Proc.Natl.Acad.Sci.USA, 106, 2009
3HFZ
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BU of 3hfz by Molmil
Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with m-tyrosine
Descriptor: META-TYROSINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain
Authors:Klipcan, L, Moor, N, Kessler, N, Safro, M.G.
Deposit date:2009-05-13
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine
Proc.Natl.Acad.Sci.USA, 106, 2009
3PCO
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BU of 3pco by Molmil
crystal structure of E. coli phenylalanine-tRNA synthetase complexed with phenylalanine and AMP
Descriptor: ADENOSINE MONOPHOSPHATE, PHENYLALANINE, Phenylalanyl-tRNA synthetase, ...
Authors:Mermershtain, I, Finarov, I, Klipcan, L, Kessler, N, Rozenberg, H, Safro, M.G.
Deposit date:2010-10-21
Release date:2011-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Idiosyncrasy and identity in the prokaryotic phe-system: crystal structure of E. coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP.
Protein Sci., 20, 2011
3TEG
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BU of 3teg by Molmil
Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNAPhe with 3,4-Dihydroxy-L-Phenylalanine (L-Dopa)
Descriptor: 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase, mitochondrial
Authors:Moor, N, Klipcan, L, Safro, M.
Deposit date:2011-08-14
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2044 Å)
Cite:Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
3TEH
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BU of 3teh by Molmil
Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with L-dopa
Descriptor: 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain
Authors:Safro, M, Klipcan, L, Moor, N.
Deposit date:2011-08-14
Release date:2011-11-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8524 Å)
Cite:Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
3TUP
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BU of 3tup by Molmil
Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state
Descriptor: Phenylalanyl-tRNA synthetase, mitochondrial, Thermus thermophilus tRNAPhe
Authors:Safro, M, Klipcan, L, Moor, N, Finarov, I, Kessler, N, Sukhanova, M.
Deposit date:2011-09-17
Release date:2011-11-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State.
J.Mol.Biol., 415, 2012
4P73
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PheRS in complex with compound 1a
Descriptor: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
Authors:Ferguson, A.D.
Deposit date:2014-03-25
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289, 2014
4P75
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PheRS in complex with compound 4a
Descriptor: 3-(3-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazole, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
Authors:Ferguson, A.D.
Deposit date:2014-03-25
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289, 2014
4P72
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PheRS in complex with compound 2a
Descriptor: 2-{3-[(4-chloropyridin-2-yl)amino]phenoxy}-N-methylacetamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
Authors:Ferguson, A.D.
Deposit date:2014-03-25
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289, 2014
4P74
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PheRS in complex with compound 3a
Descriptor: N-[(3S)-1,1-dioxidotetrahydrothiophen-3-yl]-2-[(4-methylphenoxy)methyl]-1,3-thiazole-4-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
Authors:Ferguson, A.D.
Deposit date:2014-03-25
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289, 2014
4P71
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Apo PheRS from P. aeuriginosa
Descriptor: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
Authors:Ferguson, A.D.
Deposit date:2014-03-25
Release date:2014-06-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J.Biol.Chem., 289, 2014
4TVA
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BU of 4tva by Molmil
Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of TthPheRS with Puromycine
Descriptor: PHENYLALANINE, PUROMYCIN, Phenylalanine--tRNA ligase alpha subunit, ...
Authors:Safro, M, Klipcan, L, Tworowski, D, Peretz, M.
Deposit date:2014-06-26
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin.
Proc.Natl.Acad.Sci.USA, 112, 2015
5MGH
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BU of 5mgh by Molmil
Crystal structure of pathogenic mutants of human mitochodnrial PheRS
Descriptor: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial
Authors:Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M.
Deposit date:2016-11-21
Release date:2017-05-03
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Protein Sci., 26, 2017

 

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