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8G7P
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BU of 8g7p by Molmil
Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Rybak, M.Y, Gagnon, M.G.
Deposit date:2023-02-16
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance
Nat.Struct.Mol.Biol., 2024
8G7Q
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BU of 8g7q by Molmil
Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Rybak, M.Y, Gagnon, M.G.
Deposit date:2023-02-16
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance
Nat.Struct.Mol.Biol., 2024
8V9L
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BU of 8v9l by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8QFS
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BU of 8qfs by Molmil
Cryo-EM structure of SidH from Legionella pneumophila
Descriptor: Elongation factor Tu, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sharma, R, Weis, F, Bhogaraju, S.
Deposit date:2023-09-04
Release date:2023-10-11
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for the toxicity of Legionella pneumophila effector SidH.
Nat Commun, 14, 2023
8QHC
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BU of 8qhc by Molmil
Cryo-EM structure of SidH from Legionella pneumophila in complex with LubX
Descriptor: E3 ubiquitin--protein ligase, Elongation factor Tu, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Sharma, R, Adams, M, Bhogaraju, S.
Deposit date:2023-09-07
Release date:2023-10-11
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the toxicity of Legionella pneumophila effector SidH.
Nat Commun, 14, 2023
8FR3
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BU of 8fr3 by Molmil
E. coli EF-Tu in complex with KKL-55
Descriptor: 3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide, Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Nguyen, H.A, Kuzmishin Nagy, A.B, Dunham, C.M.
Deposit date:2023-01-06
Release date:2023-09-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Antibiotic that inhibits trans -translation blocks binding of EF-Tu to tmRNA but not to tRNA.
Mbio, 14, 2023
8G60
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BU of 8g60 by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G5Z
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BU of 8g5z by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G6J
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BU of 8g6j by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)
Descriptor: (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-15
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8B6Z
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BU of 8b6z by Molmil
CryoEM Structure of Extended eEF1A bound to the Ribosome in the Classical Pre State
Descriptor: 28S ribosomal RNA, Elongation factor 1-alpha 2
Authors:Gemmer, M, Fedry, J.M.M, Forster, F.G.
Deposit date:2022-09-27
Release date:2022-12-07
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Visualization of translation and protein biogenesis at the ER membrane.
Nature, 614, 2023
7VOK
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BU of 7vok by Molmil
The Crystal structure of EF-Tu and GDP from Mycobacterium tuberculosis
Descriptor: Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Zhan, B.W, Li, J.X.
Deposit date:2021-10-14
Release date:2022-10-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Crystal structure of EF-Tu and GDP from Mycobacterium tuberculosis
to be published
7VMX
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BU of 7vmx by Molmil
The Crystal Structure of EF-Tu and EF-Ts complex from Mycobacterium tuberculosis
Descriptor: Elongation factor Ts, Elongation factor Tu, MAGNESIUM ION, ...
Authors:Zhan, B.W, Li, J.X.
Deposit date:2021-10-09
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of EF-Tu and EF-Ts complex from Mycobacterium tuberculosis
to be published
7PHA
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BU of 7pha by Molmil
70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
Deposit date:2021-08-16
Release date:2022-05-25
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7PI9
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BU of 7pi9 by Molmil
70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
Deposit date:2021-08-19
Release date:2022-05-25
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7PAJ
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BU of 7paj by Molmil
70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
Deposit date:2021-07-30
Release date:2022-05-25
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7PIP
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BU of 7pip by Molmil
70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
Deposit date:2021-08-23
Release date:2022-05-25
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (9.3 Å)
Cite:Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7PAK
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BU of 7pak by Molmil
70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Xue, L, Lenz, S, Rappsilber, J, Mahamid, J.
Deposit date:2021-07-30
Release date:2022-05-25
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
7VMC
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BU of 7vmc by Molmil
Crystal structure of EF-Tu/CdiA/CdiI
Descriptor: Contact-dependent inhibitor I, Elongation factor Tu, tRNA nuclease CdiA
Authors:Wang, J, Yashiro, Y, Tomita, K.
Deposit date:2021-10-08
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.413 Å)
Cite:Mechanistic insights into tRNA cleavage by a contact-dependent growth inhibitor protein and translation factors.
Nucleic Acids Res., 50, 2022
7ABZ
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BU of 7abz by Molmil
Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R.
Deposit date:2020-09-09
Release date:2021-08-18
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structures of tmRNA and SmpB as they transit through the ribosome.
Nat Commun, 12, 2021
7O9K
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BU of 7o9k by Molmil
Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1, the MALSU module, GTPBP5 and mtEF-Tu
Descriptor: 16S rRNA, 39S ribosomal protein L10, mitochondrial, ...
Authors:Valentin Gese, G, Hallberg, B.M.
Deposit date:2021-04-16
Release date:2021-06-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for late maturation steps of the human mitoribosomal large subunit.
Nat Commun, 12, 2021
7CSL
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BU of 7csl by Molmil
Crystal structure of the archaeal EF1A-EF1B complex
Descriptor: Elongation factor 1-alpha, Elongation factor 1-beta
Authors:Suzuki, T, Ito, K, Miyoshi, T, Murakami, R, Uchiumi, T.
Deposit date:2020-08-15
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the Switching Off of the Interaction between the Archaeal Ribosomal Stalk and aEF1A by Nucleotide Exchange Factor aEF1B.
J.Mol.Biol., 433, 2021
7A5G
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BU of 7a5g by Molmil
Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA
Descriptor: 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ...
Authors:Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V.
Deposit date:2020-08-21
Release date:2020-12-23
Method:ELECTRON MICROSCOPY (4.33 Å)
Cite:Elongational stalling activates mitoribosome-associated quality control.
Science, 370, 2020
6XK9
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BU of 6xk9 by Molmil
Cereblon in complex with DDB1, CC-90009, and GSPT1
Descriptor: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
Authors:Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P.
Deposit date:2020-06-25
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood, 137, 2021
6ZMO
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BU of 6zmo by Molmil
SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-07-03
Release date:2020-08-19
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
6WD6
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BU of 6wd6 by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-08
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020

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PDB entries from 2024-03-27

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