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8DZZ
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BU of 8dzz by Molmil
Cryo-EM structure of chi dynein bound to Lis1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Reimer, J.M, Lahiri, I, Leschziner, A.E.
Deposit date:2022-08-08
Release date:2023-08-30
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
8E00
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BU of 8e00 by Molmil
Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Reimer, J.M, Lahiri, I, Leschziner, A.E.
Deposit date:2022-08-08
Release date:2023-08-30
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
8J07
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BU of 8j07 by Molmil
96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
Descriptor: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ...
Authors:Gui, M, Brown, A.
Deposit date:2023-04-09
Release date:2023-07-26
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Axonemal structures reveal mechanoregulatory and disease mechanisms.
Nature, 618, 2023
8FDT
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BU of 8fdt by Molmil
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ...
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-04
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8FCY
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BU of 8fcy by Molmil
Engineered human dynein motor domain in microtubule-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8FDU
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BU of 8fdu by Molmil
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-04
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8FD6
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BU of 8fd6 by Molmil
Engineered human dynein motor domain in the microtubule-unbound state in the buffer containing ATP-Vi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ...
Authors:Ton, W, Wang, Y, Chai, P.
Deposit date:2022-12-02
Release date:2023-06-21
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
8GLV
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BU of 8glv by Molmil
96-nm repeat unit of doublet microtubules from Chlamydomonas reinhardtii flagella
Descriptor: 28 kDa inner dynein arm light chain, axonemal, AAA+ ATPase domain-containing protein, ...
Authors:Walton, T, Brown, A.
Deposit date:2023-03-23
Release date:2023-05-31
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Axonemal structures reveal mechanoregulatory and disease mechanisms.
Nature, 618, 2023
8BWY
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BU of 8bwy by Molmil
In situ outer dynein arm from Chlamydomonas reinhardtii in a pre-power stroke state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Calmodulin, ...
Authors:Zimmermann, N.E.L, Noga, A, Obbineni, J.M, Ishikawa, T.
Deposit date:2022-12-07
Release date:2023-05-10
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (38 Å)
Cite:ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography.
Embo J., 42, 2023
8BX8
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BU of 8bx8 by Molmil
In situ outer dynein arm from Chlamydomonas reinhardtii in the post-power stroke state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Zimmermann, N.E.L, Noga, A, Obbineni, J.M, Ishikawa, T.
Deposit date:2022-12-08
Release date:2023-05-10
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (30.299999 Å)
Cite:ATP-induced conformational change of axonemal outer dynein arms revealed by cryo-electron tomography.
Embo J., 42, 2023
8DYV
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BU of 8dyv by Molmil
Structure of human cytoplasmic dynein-1 bound to one Lis1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E.
Deposit date:2022-08-05
Release date:2023-02-01
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
8DYU
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BU of 8dyu by Molmil
Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E.
Deposit date:2022-08-05
Release date:2023-02-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
7Z8I
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BU of 7z8i by Molmil
The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-08-17
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8L
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BU of 7z8l by Molmil
Cytoplasmic dynein light intermediate chain (B1) bound to the motor domain (A2).
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8H
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BU of 7z8h by Molmil
Cytoplasmic dynein-1 motor domain AAA1, AAA2, and AAA3 subunits
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8J
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BU of 7z8j by Molmil
Cytoplasmic dynein (A2) bound to BICDR1
Descriptor: BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8F
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BU of 7z8f by Molmil
Composite structure of dynein-dynactin-BICDR on microtubules
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8G
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BU of 7z8g by Molmil
Cytoplasmic dynein-1 motor domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7Z8K
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BU of 7z8k by Molmil
Cytoplasmic dynein (A1) bound to BICDR1
Descriptor: ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, ...
Authors:Chaaban, S, Carter, A.P.
Deposit date:2022-03-17
Release date:2022-07-27
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (4.37 Å)
Cite:Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
7MGM
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BU of 7mgm by Molmil
Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lahiri, I, Reimer, J.M, Leschziner, A.E.
Deposit date:2021-04-12
Release date:2022-01-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Elife, 11, 2022
7KEK
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BU of 7kek by Molmil
Structure of the free outer-arm dynein in pre-parallel state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein alpha heavy chain, ...
Authors:Rao, Q, Zhang, K.
Deposit date:2020-10-11
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
Nat.Struct.Mol.Biol., 28, 2021
7K5B
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BU of 7k5b by Molmil
Structure of outer-arm dynein bound to microtubule doublet in microtubule binding state 2 (MTBS-2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Rao, Q, Zhang, K.
Deposit date:2020-09-16
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
Nat.Struct.Mol.Biol., 28, 2021
7K58
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BU of 7k58 by Molmil
Structure of outer-arm dyneins bound to microtubule with microtubule binding state 1(MTBS-1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ...
Authors:Qinhui, R, Kai, Z.
Deposit date:2020-09-16
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism.
Nat.Struct.Mol.Biol., 28, 2021
7MOQ
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BU of 7moq by Molmil
The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Docking complex 1 protein, ...
Authors:Kubo, S, Yang, S.K, Ichikawa, M, Bui, K.H.
Deposit date:2021-05-03
Release date:2021-07-14
Last modified:2021-09-15
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM.
Embo Rep., 22, 2021
7MI8
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BU of 7mi8 by Molmil
Signal subtracted reconstruction of AAA5 and AAA6 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 5
Descriptor: Fusion protein of Dynein and Endolysin
Authors:Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-11-03
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021

 

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