1B3U
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CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
Descriptor:PROTEIN (PROTEIN PHOSPHATASE PP2A)
Authors:Groves, M.R., Hanlon, N., Turowski, P., Hemmings, B., Barford, D.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
2PKG
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STRUCTURE OF A COMPLEX BETWEEN THE A SUBUNIT OF PROTEIN PHOSPHATASE 2A AND THE SMALL T ANTIGEN OF SV40
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
Authors:Jeffrey, P.D., Shi, Y.
Deposit date:2007-04-17
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
Nat.Struct.Mol.Biol., 14, 2007
2DB0
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CRYSTAL STRUCTURE OF PH0542
Descriptor:253aa long hypothetical protein
Authors:Nishino, A., Handa, N., Kishishita, S., Murayama, K., Shirouzu, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-14
Release date:2006-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of PH0542
To be Published
2IAE
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CRYSTAL STRUCTURE OF A PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYME.
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Cho, U.S., Xu, W.
Deposit date:2006-09-07
Release date:2006-12-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Nature, 445, 2007
2IE3
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STRUCTURE OF THE PROTEIN PHOSPHATASE 2A CORE ENZYME BOUND TO TUMOR-INDUCING TOXINS
Descriptor:Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform, ...
Authors:Xing, Y., Xu, Y., Chen, Y., Jeffrey, P.D., Chao, Y., Shi, Y.
Deposit date:2006-09-17
Release date:2006-11-07
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2IE4
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STRUCTURE OF THE PROTEIN PHOSPHATASE 2A CORE ENZYME BOUND TO OKADAIC ACID
Descriptor:Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform, ...
Authors:Xing, Y., Xu, Y., Chen, Y., Jeffrey, P.D., Chao, Y., Shi, Y.
Deposit date:2006-09-17
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2NPP
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STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYME
Descriptor:Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform, ...
Authors:Xu, Y., Chen, Y., Xing, Y., Chao, Y., Shi, Y.
Deposit date:2006-10-28
Release date:2006-12-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the protein phosphatase 2A holoenzyme
Cell(Cambridge,Mass.), 127, 2006
2NYL
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYME WITH THE CATALYTIC SUBUNIT CARBOXYL TERMINUS TRUNCATED
Descriptor:Protein phosphatase 2, regulatory subunit A (PR 65), alpha isoform, ...
Authors:Xing, Y., Xu, Y., Chen, Y., Chao, Y., Lin, Z., Shi, Y.
Deposit date:2006-11-20
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
2NYM
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE 2A (PP2A) WITH C-TERMINUS TRUNCATED CATALYTIC SUBUNIT
Descriptor:Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Chen, Y., Xing, Y., Xu, Y., Chao, Y., Lin, Z., Jeffrey, P.D., Shi, Y.
Deposit date:2006-11-21
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
2PF4
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CRYSTAL STRUCTURE OF THE FULL-LENGTH SIMIAN VIRUS 40 SMALL T ANTIGEN COMPLEXED WITH THE PROTEIN PHOSPHATASE 2A AALPHA SUBUNIT
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
Authors:Cho, U., Morrone, S., Xu, W.
Deposit date:2007-04-03
Release date:2007-08-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of PP2A inhibition by small t antigen.
Plos Biol., 5, 2007
3C5W
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COMPLEX BETWEEN PP2A-SPECIFIC METHYLESTERASE PME-1 AND PP2A CORE ENZYME
Descriptor:PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1
Authors:Xing, Y., Li, Z., Chen, Y., Stock, J., Jeffrey, P.D., Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
3DW8
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STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME WITH B55 SUBUNIT
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Xu, Y., Chen, Y., Zhang, P., Jeffrey, P.D., Shi, Y.
Deposit date:2008-07-21
Release date:2008-10-07
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Mol.Cell, 31, 2008
3FGA
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STRUCTURAL BASIS OF PP2A AND SGO INTERACTION
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Xu, Z., Xu, W.
Deposit date:2008-12-05
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of the PP2A-shugoshin interaction
Mol.Cell, 35, 2009
3K7V
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PROTEIN PHOSPHATASE 2A CORE COMPLEX BOUND TO DINOPHYSISTOXIN-1
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, SULFATE ION, ...
Authors:Jeffrey, P.D., Huhn, J., Shi, Y.
Deposit date:2009-10-13
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A structural basis for the reduced toxicity of dinophysistoxin-2.
Chem.Res.Toxicol., 22, 2009
3K7W
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PROTEIN PHOSPHATASE 2A CORE COMPLEX BOUND TO DINOPHYSISTOXIN-2
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, SULFATE ION, ...
Authors:Jeffrey, P.D., Huhn, J., Shi, Y.
Deposit date:2009-10-13
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:A structural basis for the reduced toxicity of dinophysistoxin-2.
Chem.Res.Toxicol., 22, 2009
3ND2
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STRUCTURE OF YEAST IMPORTIN-BETA (KAP95P)
Descriptor:Importin subunit beta-1
Authors:Forwood, J.K., Kobe, B.
Deposit date:2010-06-06
Release date:2010-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures
Structure, 18, 2010
4I5L
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STRUCTURAL MECHANISM OF TRIMERIC PP2A HOLOENZYME INVOLVING PR70: INSIGHT FOR CDC6 DEPHOSPHORYLATION
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wlodarchak, N., Satyshur, K.A., Guo, F., Xing, Y.
Deposit date:2012-11-28
Release date:2013-05-08
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Cell Res., 23, 2013
4I5N
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STRUCTURAL MECHANISM OF TRIMERIC PP2A HOLOENZYME INVOLVING PR70: INSIGHT FOR CDC6 DEPHOSPHORYLATION
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wlodarchak, N., Satyshur, K.A., Guo, F., Xing, Y.
Deposit date:2012-11-28
Release date:2013-05-08
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Cell Res., 23, 2013
5OWU
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KAP95:NUP1 COMPLEX
Descriptor:Importin subunit beta-1, Nucleoporin NUP1
Authors:Stewart, M.
Deposit date:2017-09-04
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
J. Mol. Biol., 349, 2005
5W0W
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE 2A BOUND TO TIPRL
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, TIP41-like protein, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wu, C., Zheng, A., Li, J., Satyshur, K., Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
2BKU
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KAP95P:RANGTP COMPLEX
Descriptor:GTP-BINDING NUCLEAR PROTEIN RAN, IMPORTIN BETA-1 SUBUNIT, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Lee, S.J., Matsuura, Y., Liu, S.M., Stewart, M.
Deposit date:2005-02-21
Release date:2005-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Nuclear Import Complex Dissociation by Rangtp
Nature, 435, 2005
3EA5
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KAP95P BINDING INDUCES THE SWITCH LOOPS OF RANGDP TO ADOPT THE GTP-BOUND CONFORMATION: IMPLICATIONS FOR NUCLEAR IMPORT COMPLEX ASSEMBLY DYNAMICS
Descriptor:GTP-binding nuclear protein Ran, Importin subunit beta-1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Forwood, J.K., Lonhienne, J.K., Guncar, G., Stewart, M., Marfori, M., Kobe, B.
Deposit date:2008-08-24
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
5H64
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CRYO-EM STRUCTURE OF MTORC1
Descriptor:Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M., Wong, C.C.L., Wang, J., Xu, Y., Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
6BCU
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CRYO-EM STRUCTURE OF THE ACTIVATED RHEB-MTORC1 REFINED TO 3.4 ANGSTROM
Descriptor:Serine/threonine-protein kinase mTOR,Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR,Regulatory-associated protein of mTOR, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-10-20
Release date:2017-12-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
6BCX
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MTORC1 STRUCTURE REFINED TO 3.0 ANGSTROMS
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-10-20
Release date:2017-12-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
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