4J9Y
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CALCIUM-CALMODULIN COMPLEXED WITH THE CALMODULIN BINDING DOMAIN FROM A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2013-02-17
Release date:2013-03-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
5V03
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A POSITIVE ALLOSTERIC MODULATOR BINDING POCKET IN SK2 ION CHANNELS IS SHARED BY RILUZOLE AND CYPPA
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
1G4Y
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1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN
Descriptor:CALCIUM-ACTIVATED POTASSIUM CHANNEL RSK2, CALMODULIN, SULFATE ION, ...
Authors:Schumacher, M.A., Rivard, A., Bachinger, H.P., Adelman, J.P.
Deposit date:2001-01-07
Release date:2001-05-09
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.
Nature, 410, 2001
4G28
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CALCIUM-CALMODULIN COMPLEXED WITH THE CALMODULIN BINDING DOMAIN FROM A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT AND EBIO-1
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2012-07-11
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
4G27
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CALCIUM-CALMODULIN COMPLEXED WITH THE CALMODULIN BINDING DOMAIN FROM A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT AND PHENYLUREA
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2012-07-11
Release date:2012-09-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
4J9Z
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CALCIUM-CALMODULIN COMPLEXED WITH THE CALMODULIN BINDING DOMAIN FROM A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT AND NS309
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2013-02-17
Release date:2013-03-27
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
5V02
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A POSITIVE ALLOSTERIC MODULATOR BINDING POCKET IN SK2 ION CHANNELS IS SHARED BY RILUZOLE AND CYPPA
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin-1, SULFATE ION, ...
Authors:Liu, S.
Deposit date:2017-02-28
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure, 26, 2018
3SJQ
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CRYSTAL STRUCTURE OF A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT COMPLEXED WITH CALCIUM-CALMODULIN
Descriptor:Calmodulin, Small conductance calcium-activated potassium channel protein 2, CALCIUM ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2011-06-21
Release date:2012-05-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for calmodulin as a dynamic calcium sensor.
Structure, 20, 2012
5WBX
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STRUCTURAL INSIGHTS INTO THE POTENCY OF SK/IK CHANNEL POSITIVE MODULATORS
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin-1, SULFATE ION, ...
Authors:Nam, Y.W., Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
4QNH
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CALCIUM-CALMODULIN (T79D) COMPLEXED WITH THE CALMODULIN BINDING DOMAIN FROM A SMALL CONDUCTANCE POTASSIUM CHANNEL SK2-A
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin, SULFATE ION, ...
Authors:Zhang, M., Pascal, J.M., Logothetis, D.E., Zhang, J.F.
Deposit date:2014-06-17
Release date:2014-08-06
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.
Nat.Chem.Biol., 10, 2014
6CZQ
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A V-TO-F SUBSTITUTION IN SK2 CHANNELS CAUSES CA2+ HYPERSENSITIVITY AND IMPROVES LOCOMOTION IN A C. ELEGANS ALS MODEL
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin-1, SULFATE ION, ...
Authors:Nam, Y.W., Zhang, M.
Deposit date:2018-04-09
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model.
Sci Rep, 8, 2018
5WC5
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STRUCTURAL INSIGHTS INTO THE POTENCY OF SK/IK CHANNEL POSITIVE MODULATORS
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin-1, SULFATE ION, ...
Authors:Nam, Y.W., Zhang, M.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the potency of SK channel positive modulators.
Sci Rep, 7, 2017
6ALE
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A V-TO-F SUBSTITUTION IN SK2 CHANNELS CAUSES CA2+ HYPERSENSITIVITY AND IMPROVES LOCOMOTION IN A C. ELEGANS ALS MODEL
Descriptor:Small conductance calcium-activated potassium channel protein 2, Calmodulin-2, SULFATE ION, ...
Authors:Nam, Y.W., Zhang, M.
Deposit date:2017-08-07
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Calcium-calmodulin complexed with the calmodulin binding domain from a mutant small conductance potassium channel and NS309
To Be Published
1QX7
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CRYSTAL STRUCTURE OF APOCAM BOUND TO THE GATING DOMAIN OF SMALL CONDUCTANCE CA2+-ACTIVATED POTASSIUM CHANNEL
Descriptor:Calmodulin, Small conductance calcium-activated potassium channel protein 2
Authors:Schumacher, M.A., Crum, M., Miller, M.C.
Deposit date:2003-09-04
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.
STRUCTURE, 12, 2004
6CNM
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, POTASSIUM ION, ...
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNN
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX IN THE CA2+ BOUND STATE I
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, POTASSIUM ION, ...
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
6CNO
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CRYO-EM STRUCTURE OF THE HUMAN SK4/CALMODULIN CHANNEL COMPLEX IN THE CA2+ BOUND STATE II
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, Calmodulin-1, CALCIUM ION
Authors:Lee, C.H., MacKinnon, R.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Science, 360, 2018
1KKD
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SOLUTION STRUCTURE OF THE CALMODULIN BINDING DOMAIN (CAMBD) OF SMALL CONDUCTANCE CA2+-ACTIVATED POTASSIUM CHANNELS (SK2)
Descriptor:Small conductance calcium-activated potassium channel protein 2
Authors:Wissmann, R., Bildl, W., Neumann, H., Rivard, A.F., Kloecker, N., Weitz, D., Schulte, U., Adelman, J.P., Bentrop, D., Fakler, B.
Deposit date:2001-12-07
Release date:2001-12-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin.
J.Biol.Chem., 277, 2002
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