7R1R
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RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
6R1R
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RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
6CGN
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X-RAY CRYSTAL STRUCTURE OF BACILLUS SUBTILIS RIBONUCLEOTIDE REDUCTASE NRDE ALPHA SUBUNIT DAMP-BOUND (PH 7)
Descriptor:Ribonucleoside-diphosphate reductase, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Maggiolo, A.O., Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGM
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X-RAY CRYSTAL STRUCTURE OF BACILLUS SUBTILIS RIBONUCLEOTIDE REDUCTASE NRDE ALPHA SUBUNIT (NUCLEOTIDE FREE)
Descriptor:Ribonucleoside-diphosphate reductase, 1,2-ETHANEDIOL
Authors:Maggiolo, A.O., Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGL
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X-RAY CRYSTAL STRUCTURE OF BACILLUS SUBTILIS RIBONUCLEOTIDE REDUCTASE NRDE ALPHA SUBUNIT DAMP-BOUND AS-ISOLATED (PH 4)
Descriptor:Ribonucleoside-diphosphate reductase, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, SULFATE ION
Authors:Maggiolo, A.O., Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AUI
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HUMAN RIBONUCLEOTIDE REDUCTASE LARGE SUBUNIT (ALPHA) WITH DATP AND CDP
Descriptor:Ribonucleoside-diphosphate reductase large subunit, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Brignole, E.J., Drennan, C.L., Asturias, F.J., Tsai, K.L., Penczek, P.A.
Deposit date:2017-09-01
Release date:2018-04-18
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
Elife, 7, 2018
5TUS
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POTENT COMPETITIVE INHIBITION OF HUMAN RIBONUCLEOTIDE REDUCTASE BY A NOVEL NON-NUCLEOSIDE SMALL MOLECULE
Descriptor:Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Mohammed, F.A., Alam, I., Dealwis, C.G.
Deposit date:2016-11-07
Release date:2017-08-02
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5R1R
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RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
5IM3
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CRYSTAL STRUCTURE OF THE CLASS I RIBONUCLEOTIDE REDUCTASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH DATP
Descriptor:Ribonucleoside-diphosphate reductase, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Johansson, R., Logan, D.T.
Deposit date:2016-03-05
Release date:2016-05-04
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.
Structure, 24, 2016
5D1Y
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LOW RESOLUTION CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE ALPHA6 HEXAMER IN COMPLEX WITH DATP
Descriptor:Ribonucleoside-diphosphate reductase large subunit
Authors:Ando, N., Li, H., Brignole, E.J., Thompson, S., McLaughlin, M.I., Page, J., Asturias, F., Stubbe, J., Drennan, C.L.
Deposit date:2015-08-04
Release date:2016-01-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (9.005 Å)
Cite:Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.
Biochemistry, 55, 2016
5CNV
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX BOUND TO GDP AND TTP AT 3.20 ANGSTROMS RESOLUTION
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Chen, P.Y.-T., Zimanyi, C.M., Funk, M.A., Drennan, C.L.
Deposit date:2015-07-18
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
Elife, 5, 2016
5CNU
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX BOUND TO ADP AND DGTP AT 3.40 ANGSTROMS RESOLUTION
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, P.Y.-T., Zimanyi, C.M., Funk, M.A., Drennan, C.L.
Deposit date:2015-07-18
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
Elife, 5, 2016
5CNT
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX BOUND TO UDP AND DATP AT 3.25 ANGSTROMS RESOLUTION
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, URIDINE-5'-DIPHOSPHATE, ...
Authors:Chen, P.Y.-T., Zimanyi, C.M., Funk, M.A., Drennan, C.L.
Deposit date:2015-07-18
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
Elife, 5, 2016
5CNS
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX BOUND TO CDP AND DATP AT 2.97 ANGSTROMS RESOLUTION
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, CYTIDINE-5'-DIPHOSPHATE, ...
Authors:Chen, P.Y.-T., Zimanyi, C.M., Funk, M.A., Drennan, C.L.
Deposit date:2015-07-18
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.975 Å)
Cite:Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
Elife, 5, 2016
4X3V
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CRYSTAL STRUCTURE OF HUMAN RIBONUCLEOTIDE REDUCTASE 1 BOUND TO INHIBITOR
Descriptor:Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine
Authors:Dealwis, C.G., Ahmad, M.F., Alam, I.
Deposit date:2014-12-01
Release date:2015-11-11
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58, 2015
4R1R
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RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI
Descriptor:RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Eriksson, M., Eklund, H.
Deposit date:1997-07-22
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
4ERP
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CRYSTAL STRUCTURE OF A GEMCITABINE-DIPHOSPHATE INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zimanyi, C.M., Drennan, C.L.
Deposit date:2012-04-20
Release date:2012-07-04
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (4.45 Å)
Cite:Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.
Structure, 20, 2012
4ERM
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX AT 4 ANGSTROMS RESOLUTION
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ...
Authors:Zimanyi, C.M., Drennan, C.L.
Deposit date:2012-04-20
Release date:2012-07-04
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.
Structure, 20, 2012
3UUS
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CRYSTAL STRUCTURE OF THE DATP INHIBITED E. COLI CLASS IA RIBONUCLEOTIDE REDUCTASE COMPLEX
Descriptor:Ribonucleoside-diphosphate reductase 1 subunit alpha, Ribonucleoside-diphosphate reductase 1 subunit beta, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ...
Authors:Zimanyi, C.M., Drennan, C.L.
Deposit date:2011-11-28
Release date:2011-12-21
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (5.65 Å)
Cite:Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TBA
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 Q288A WITH DGTP AND ADP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.
Deposit date:2011-08-05
Release date:2012-04-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
3TB9
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 Q288A WITH AMPPNP AND CDP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, CYTIDINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
Deposit date:2011-08-05
Release date:2012-04-04
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
J.Mol.Biol., 419, 2012
3S8C
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 R293A WITH AMPPNP AND CDP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
Deposit date:2011-05-27
Release date:2012-04-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
3S8B
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 WITH AMPPNP AND CDP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, CYTIDINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
Deposit date:2011-05-27
Release date:2012-04-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
3S8A
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE R293A WITH DGTP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
Deposit date:2011-05-27
Release date:2012-04-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
3S87
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STRUCTURE OF YEAST RIBONUCLEOTIDE REDUCTASE 1 WITH DGTP AND ADP
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Ahmad, M.F., Kaushal, P.S., Wan, Q., Wijeratna, S.R., Huang, M., Dealwis, C.D.
Deposit date:2011-05-27
Release date:2012-04-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
To be Published
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