2G76
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE
Descriptor:D-3-phosphoglycerate dehydrogenase, D-MALATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Turnbull, A.P., Salah, E., Savitsky, P., Gileadi, O., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-02-27
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human 3-phosphoglycerate dehydrogenase
To be Published
3GVX
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CRYSTAL STRUCTURE OF GLYCERATE DEHYDROGENASE RELATED PROTEIN FROM THERMOPLASMA ACIDOPHILUM
Descriptor:Glycerate dehydrogenase related protein, POTASSIUM ION
Authors:Syed Ibrahim, B., Kumaran, D., Burley, S.K., Swaminathan, S., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-03-31
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Glycerate dehydrogenase related protein from Thermoplasma acidophilum
To be Published
3HG7
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CRYSTAL STRUCTURE OF D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN FROM AEROMONAS SALMONICIDA SUBSP. SALMONICIDA A449
Descriptor:D-isomer specific 2-hydroxyacid dehydrogenase family protein, GLYCEROL
Authors:Malashkevich, V.N., Toro, R., Morano, C., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-05-13
Release date:2009-05-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:CRYSTAL STRUCTURE OF D-isomer specific 2-hydroxyacid dehydrogenase family protein from Aeromonas salmonicida subsp. salmonicida A449
To be Published
3KBO
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2.14 ANGSTROM CRYSTAL STRUCTURE OF PUTATIVE OXIDOREDUCTASE (YCDW) FROM SALMONELLA TYPHIMURIUM IN COMPLEX WITH NADP
Descriptor:Glyoxylate/hydroxypyruvate reductase A, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(2-hydroxyethyl)-N,N-dimethyl-3-sulfopropan-1-aminium, ...
Authors:Minasov, G., Wawrzak, Z., Skarina, T., Onopriyenko, O., Papazisi, L., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-10-20
Release date:2009-10-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:2.14 Angstrom Crystal Structure of Putative Oxidoreductase (ycdW) from Salmonella typhimurium in Complex with NADP.
To be Published
3PP8
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2.1 ANGSTROM CRYSTAL STRUCTURE OF PUTATIVE OXIDOREDUCTASE (YCDW) FROM SALMONELLA TYPHIMURIUM
Descriptor:Glyoxylate/hydroxypyruvate reductase A
Authors:Minasov, G., Wawrzak, Z., Skarina, T., Wang, Y., Papazisi, L., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-11-24
Release date:2010-12-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 Angstrom Crystal Structure of Putative Oxidoreductase (ycdW) from Salmonella typhimurium.
TO BE PUBLISHED
4HY3
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CRYSTAL STRUCTURE OF A PHOSPHOGLYCERATE OXIDOREDUCTASE FROM RHIZOBIUM ETLI
Descriptor:phosphoglycerate oxidoreductase
Authors:Kumaran, D., Chamala, S., Evans, B., Foti, R., Gizzi, A., Hillerich, B., Kar, A., Lafleur, J., Seidel, R., Villigas, G., Zencheck, W., Almo, S.C., Swaminathan, S., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-11-12
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a phosphoglycerate oxidoreductase from rhizobium etli
To be Published
4N18
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CRYSTAL STRUCTURE OF D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN FROM KLEBSIELLA PNEUMONIAE 342
Descriptor:D-isomer specific 2-hydroxyacid dehydrogenase family protein, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CITRIC ACID
Authors:Bacal, P., Shabalin, I.G., Cooper, D.R., Majorek, K.A., Osinski, T., Hillerich, B.S., Hammonds, J., Nawar, A., Stead, M., Chowdhury, S., Gizzi, A., Bonanno, J., Seidel, R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2013-10-03
Release date:2013-10-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of D-isomer specific 2-hydroxyacid dehydrogenase family protein from Klebsiella pneumoniae 342
To be Published
4WEQ
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CRYSTAL STRUCTURE OF NADPH-DEPENDENT GLYOXYLATE/HYDROXYPYRUVATE REDUCTASE SMC02828 (SMGHRA) FROM SINORHIZOBIUM MELILOTI IN COMPLEX WITH NADP AND SULFATE
Descriptor:NAD-dependent dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
Authors:Sroka, P., Gasiorowska, O.A., Handing, K.B., Shabalin, I.G., Osinski, T., Hillerich, B.S., Bonanno, J., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-09-10
Release date:2014-09-24
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.
Biochemistry, 57, 2018
4XA8
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CRYSTAL STRUCTURE OF D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FROM XANTHOBACTER AUTOTROPHICUS PY2
Descriptor:D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Authors:Handing, K.B., Gasiorowska, O.A., Shabalin, I.G., Cymborowski, M.T., Bonanno, J., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-12-12
Release date:2015-01-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of D-isomer specific 2-hydroxyacid dehydrogenase from Xanthobacter autotrophicus Py2.
to be published
4XCV
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PROBABLE 2-HYDROXYACID DEHYDROGENASE FROM RHIZOBIUM ETLI CFN 42 IN COMPLEX WITH NADPH
Descriptor:NADP-dependent 2-hydroxyacid dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CHLORIDE ION, ...
Authors:Langner, K.M., Shabalin, I.G., Handing, K.B., Gasiorowska, O.A., Stead, M., Hillerich, B.S., Chowdhury, S., Hammonds, J., Zimmerman, M.D., Al Obadi, N., Bonanno, J., Seidel, R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-12-18
Release date:2014-12-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of 2-hydroxyacid dehydrogenase from Rhizobium etli CFN 42 in complex with NADPH
to be published
4Z0P
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CRYSTAL STRUCTURE OF NADPH-DEPENDENT GLYOXYLATE/HYDROXYPYRUVATE REDUCTASE SMC02828 (SMGHRA) FROM SINORHIZOBIUM MELILOTI IN COMPLEX WITH NADPH AND OXALATE
Descriptor:NAD-dependent dehydrogenase, CHLORIDE ION, OXALIC ACID, ...
Authors:Sroka, P., Gasiorowska, O.A., Handing, K.B., Shabalin, I.G., Porebski, P.J., Hillerich, B.S., Bonanno, J., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2015-03-26
Release date:2015-04-08
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.
Biochemistry, 57, 2018
4ZQB
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CRYSTAL STRUCTURE OF NADP-DEPENDENT DEHYDROGENASE FROM RHODOBACTERSPHAEROIDES IN COMPLEX WITH NADP AND SULFATE
Descriptor:NADP-dependent dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
Authors:Kowiel, M., Gasiorowska, O.A., Shabalin, I.G., Handing, K.B., Porebski, P.J., Bonanno, J., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2015-05-08
Release date:2015-05-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of NADP-dependent dehydrogenase from Rhodobactersphaeroides in complex with NADP and sulfate
to be published
5BQF
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PROBABLE 2-HYDROXYACID DEHYDROGENASE FROM RHIZOBIUM ETLI CFN 42 IN COMPLEX WITH NADP, HEPES AND L(+)-TARTARIC ACID
Descriptor:NADP-dependent 2-hydroxyacid dehydrogenase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Langner, K.M., Shabalin, I.G., Handing, K.B., Gasiorowska, O.A., Stead, M., Hillerich, B.S., Chowdhury, S., Hammonds, J., Zimmerman, M.D., Al Obaidi, N., Bonanno, J., Seidel, R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2015-05-29
Release date:2015-06-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Probable 2-hydroxyacid dehydrogenase from Rhizobium etli CFN 42 in complex with NADP, HEPES and L-tartaric acid
to be published
5C5I
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CRYSTAL STRUCTURE OF NADP-DEPENDENT DEHYDROGENASE FROM RHODOBACTER SPHAEROIDES
Descriptor:NADP-dependent dehydrogenase
Authors:Kowiel, M., Gasiorowska, O.A., Shabalin, I.G., Handing, K.B., Porebski, P.J., Cymborowski, M., Al Obaidi, N.F., Bonanno, J., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2015-06-19
Release date:2015-07-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of NADP-dependent dehydrogenase from Rhodobacter sphaeroides
to be published
5MH5
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D-2-HYDROXYACID DEHYDROGENASES (D2-HDH) FROM HALOFERAX MEDITERRANEI IN COMPLEX WITH 2-KETO-HEXANOIC ACID AND NADP+ (1.4 A RESOLUTION)
Descriptor:D-2-hydroxyacid dehydrogenase, MAGNESIUM ION, 2-Ketohexanoic acid, ...
Authors:Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J.
Deposit date:2016-11-23
Release date:2018-05-02
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism
To Be Published
5MH6
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D-2-HYDROXYACID DEHYDROGENASES (D2-HDH) FROM HALOFERAX MEDITERRANEI IN COMPLEX WITH 2-KETOHEXANOIC ACID AND NAD+ (1.35 A RESOLUTION)
Descriptor:D-2-hydroxyacid dehydrogenase, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J.
Deposit date:2016-11-23
Release date:2018-06-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism
To Be Published
5MHA
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D-2-HYDROXYACID DEHYDROGENASES (D2-HDH) FROM HALOFERAX MEDITERRANEI IN COMPLEX WITH A MIXTURE OF 2-KETOHEXANOIC ACID AND 2-HYDROXYHEXANOIC ACID, AND NADPH (1.57 A RESOLUTION)
Descriptor:D-2-hydroxyacid dehydrogenase, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J.
Deposit date:2016-11-23
Release date:2018-05-09
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism
To Be Published
5N53
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH N-(3-CHLORO-4-METHOXYPHENYL) ACETAMIDE
Descriptor:D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-02-12
Release date:2017-04-05
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
5N6C
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH NAD AND L-TARTRATE
Descriptor:D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Unterlass, J.E., Basle, A., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-02-14
Release date:2017-11-22
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).
Oncotarget, 8, 2017
5NZO
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 1-METHYL-3-PHENYL-1H-PYRAZOL-5-AMINE
Descriptor:D-3-phosphoglycerate dehydrogenase, 2-methyl-5-phenyl-pyrazol-3-amine
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-05-14
Release date:2017-06-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
5NZP
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 3-HYDROXYBENZISOXAZOLE
Descriptor:D-3-phosphoglycerate dehydrogenase, 1,2-benzoxazol-3-ol
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-05-14
Release date:2017-06-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
5NZQ
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 3-(1,3-OXAZOL-5-YL)ANILINE.
Descriptor:D-3-phosphoglycerate dehydrogenase, 3-(1,3-oxazol-5-yl)aniline
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-05-14
Release date:2017-06-14
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
5OFM
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 5-AMINO-1-METHYL-1H-INDOLE
Descriptor:D-3-phosphoglycerate dehydrogenase, 1-methylindol-5-amine
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-07-11
Release date:2017-08-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1H-indole
To be published
5OFV
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 5-FLUORO-2-METHYLBENZOIC ACID
Descriptor:D-3-phosphoglycerate dehydrogenase, 5-fluoranyl-2-methyl-benzoic acid
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-07-11
Release date:2017-08-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
5OFW
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CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASE IN COMPLEX WITH 3-CHLORO-4-FLUOROBENZAMIDE
Descriptor:D-3-phosphoglycerate dehydrogenase, 3-chloranyl-4-fluoranyl-benzamide
Authors:Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Deposit date:2017-07-11
Release date:2017-08-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
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