PDB: 17 resultsInfo pagesStatus searchChemie searchBIRD

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3V3L	Crystal structure of human RNF146 WWE domain in complex with iso-ADPRibose Descriptor: 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146 Authors: Wang, Z, Cheng, Z, Xu, W. Deposit date: 2011-12-13 Release date: 2012-02-15 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev., 26, 2012
4QPL	Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex Descriptor: 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, ... Authors: Wang, Z, DaRosa, P.A, Klevit, R.E, Xu, W. Deposit date: 2014-06-23 Release date: 2014-10-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature, 517, 2015
7TGQ	Zinc finger antiviral protein (ZAP) central domain bound to ADP-ribose Descriptor: ACETATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ZINC ION, ... Authors: Pornillos, O.P. Deposit date: 2022-01-09 Release date: 2022-02-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Poly(ADP-ribose) potentiates ZAP antiviral activity. Plos Pathog., 18, 2022
6MIW	WWE domain of human HUWE1 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION Authors: Halabelian, L, Loppnau, P, Tempel, W, Wong, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) Deposit date: 2018-09-20 Release date: 2018-10-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: WWE domain of human HUWE1 To Be Published
6PFL	Crystal structure of Human HUWE1 WWE domain in complex with ADPR Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION Authors: Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) Deposit date: 2019-06-21 Release date: 2019-07-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of Human HUWE1 WWE domain in complex with ADPR to be published
2A90	Crystal Structure of the tandem WWE domain of Drosophila Deltex Descriptor: Deltex protein Authors: Zweifel, M.E, Leahy, D.J, Barrick, D. Deposit date: 2005-07-10 Release date: 2005-11-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure and Notch Receptor Binding of the Tandem WWE Domain of Deltex. Structure, 13, 2005
7SZ2	Mouse PARP13/ZAP ZnF5-WWE1-WWE2 bound to ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, PHOSPHATE ION, ... Authors: Ayanath Kuttiyatveetil, J.R, Pascal, J.M. Deposit date: 2021-11-25 Release date: 2022-10-05 Last modified: 2022-11-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose). Cell Rep, 41, 2022
7SZ3	Mouse PARP13/ZAP ZnF5-WWE1-WWE2 bound to ADPr Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, GLYCEROL, PHOSPHATE ION, ... Authors: Ayanath Kuttiyatveetil, J.R, Pascal, J.M. Deposit date: 2021-11-25 Release date: 2022-10-05 Last modified: 2022-11-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose). Cell Rep, 41, 2022
7KZH	Zinc finger antiviral protein (ZAP) central domain Descriptor: ZINC ION, Zinc finger CCCH-type antiviral protein 1 Authors: Pornillos, O.P. Deposit date: 2020-12-10 Release date: 2021-12-15 Last modified: 2023-01-11 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Poly(ADP-ribose) potentiates ZAP antiviral activity. Plos Pathog., 18, 2022
7JQ9	Cryo-EM structure of human HUWE1 Descriptor: E3 ubiquitin-protein ligase HUWE1 Authors: Hunkeler, M, Fischer, E.S. Deposit date: 2020-08-10 Release date: 2021-07-28 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MWF	HUWE1 in map with focus on interface Descriptor: E3 ubiquitin-protein ligase HUWE1 Authors: Hunkeler, M, Fischer, E.S. Deposit date: 2021-05-16 Release date: 2021-07-28 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MOP	Cryo-EM structure of human HUWE1 in complex with DDIT4 Descriptor: DNA damage-inducible transcript 4 protein, E3 ubiquitin-protein ligase HUWE1 Authors: Hunkeler, M, Fischer, E.S. Deposit date: 2021-05-03 Release date: 2021-07-28 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MWE	HUWE1 in map with focus on WWE Descriptor: E3 ubiquitin-protein ligase HUWE1 Authors: Hunkeler, M, Fischer, E.S. Deposit date: 2021-05-16 Release date: 2021-07-28 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
7MWD	HUWE1 in map with focus on HECT Descriptor: E3 ubiquitin-protein ligase HUWE1 Authors: Hunkeler, M, Fischer, E.S. Deposit date: 2021-05-16 Release date: 2021-07-28 Last modified: 2021-09-15 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
1UJR	Solution structure of WWE domain in BAB28015 Descriptor: hypothetical protein AK012080 Authors: He, F, Muto, Y, Hamana, H, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Kobayashi, N, Tanaka, A, Osanai, T, Matsuo, Y, Ohara, O, Nagase, T, Kikuno, R, Nagayama, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2003-08-11 Release date: 2004-10-05 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of WWE domain in BAB28015 To be Published
2DK6	Solution structure of WWE domain in poly (ADP-ribose) polymerase family, member 11 (PARP 11) Descriptor: PARP11 protein Authors: He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-06 Release date: 2007-04-24 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Solution structure of WWE domain in poly (ADP-ribose) polymerase family, member 11 (PARP 11) To be Published
2RSF	Complex structure of WWE in RNF146 with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF146 Authors: He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2012-01-31 Release date: 2013-03-06 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Complex structure of WWE domain in RNF146 with ATP To be Published