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1KAS
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BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL ACP SYNTHASE II
Authors:Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y.
Deposit date:1997-12-22
Release date:1999-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.
EMBO J., 17, 1998
1B3N
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BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.
Descriptor: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2)
Authors:Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y.
Deposit date:1998-12-14
Release date:1999-04-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.
J.Biol.Chem., 274, 1999
1DD8
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CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI
Descriptor: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I
Authors:Olsen, J.G, Kadziola, A, von Wettstein-Knowles, P, Siggaard-Andersen, M, Lindquist, Y, Larsen, S.
Deposit date:1999-11-09
Release date:1999-11-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I.
FEBS Lett., 460, 1999
1EK4
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BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH DODECANOIC ACID TO 1.85 RESOLUTION
Descriptor: BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I, LAURIC ACID
Authors:Olsen, J.G, Kadziola, A, Siggaard-Andersen, M, von Wettstein-Knowles, P, Larsen, S.
Deposit date:2000-03-06
Release date:2001-04-11
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
1F91
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BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I IN COMPLEX WITH C10 FATTY ACID SUBSTRATE
Descriptor: BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, DECANOIC ACID, HYDROXIDE ION
Authors:Olsen, J.G, Kadziola, A, Wettstein-Knowles, P.V, Siggaard-Andersen, M, Larsen, S.
Deposit date:2000-07-06
Release date:2001-04-11
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.
Structure, 9, 2001
1E5M
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Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp.
Descriptor: BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II
Authors:Moche, M, Edwards, P, Dehesh, K, Lindqvist, Y.
Deposit date:2000-07-27
Release date:2001-01-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:The Crystal Structure of Beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis Sp. At 1.54 A Resolution and its Relationship to Other Condensing Enzymes
J.Mol.Biol., 305, 2001
1FJ8
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN
Descriptor: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I
Authors:Price, A.C, Choi, K, Heath, R.J, Li, Z, White, S.W, Rock, C.O.
Deposit date:2000-08-07
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1FJ4
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN
Descriptor: BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, THIOLACTOMYCIN
Authors:Price, A.C, Choi, K, Heath, R.J, Li, Z, White, S.W, Rock, C.O.
Deposit date:2000-08-07
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1G5X
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The Structure of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase I
Descriptor: BETA-KETOACYL ACYL CARRIER PROTEIN SYNTHASE I
Authors:Zhang, Y.M, Rao, M.S, Heath, R.J, Price, A.C, Olson, A.J, Rock, C.O, White, S.W.
Deposit date:2000-11-02
Release date:2000-11-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
J.Biol.Chem., 276, 2001
1J3N
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Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8
Descriptor: 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION
Authors:Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-02-10
Release date:2003-03-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 64, 2008
1H4F
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E. COLI BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I K328R
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION
Authors:Olsen, J.G, von Wettstein-Knowles, P, Mcguire, K.A, Henriksen, A.
Deposit date:2003-02-26
Release date:2004-03-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
1OX0
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-03-31
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1OXH
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form
Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
Authors:Price, A.C, Rock, C.O, White, S.W.
Deposit date:2003-04-02
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1W0I
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Arabidopsis thaliana Mitochondrial KAS
Descriptor: 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION
Authors:Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2004-06-04
Release date:2004-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
FEBS Lett., 577, 2004
1TQY
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The Actinorhodin Ketosynthase/Chain Length Factor
Descriptor: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
Authors:Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
Deposit date:2004-06-18
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
2BUH
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E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I, 120 K
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION
Authors:Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-06-13
Release date:2005-06-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BUI
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E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I IN COMPLEX WITH OCTANOIC ACID, 120K
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, OCTANOIC ACID (CAPRYLIC ACID)
Authors:Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-06-13
Release date:2005-06-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2ALM
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Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
Descriptor: 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION
Authors:Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O.
Deposit date:2005-08-07
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.
J.Biol.Chem., 281, 2006
2BYX
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KAS I LYS328ALA Mutant in complex with fatty acid
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-09
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BYZ
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Structure of E.coli KAS I H298Q mutant in complex with C12 fatty acid
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-09
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BYW
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Structure of Escherichia coli beta-ketoacyl (acyl carrier protein) synthase I LYS328ALA mutant
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-09
Release date:2005-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BYY
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E.coli KAS I H298E Mutation
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-09
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BZ3
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Structure of E.coli KAS I H298E mutant in complex with C12 fatty acid
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID, ...
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-10
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2BZ4
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structure of E.coli KAS I H298Q mutant
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, SULFATE ION
Authors:Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A.
Deposit date:2005-08-10
Release date:2006-02-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
2AQ7
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Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
Descriptor: (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I
Authors:Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006

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