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8FI5
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Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 2)
Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-12-15
Release date:2022-12-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 2)
To be published
8FI6
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Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 3)
Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-12-15
Release date:2022-12-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 3)
To be published
8FI4
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Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 1)
Descriptor: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-12-15
Release date:2022-12-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase) (NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA (Orthorhombic P Form 1)
To be published
8FBT
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Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-30
Release date:2023-05-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
8FBU
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BU of 8fbu by Molmil
Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and Compound-2
Descriptor: (2M)-2-[2-(piperazin-1-yl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-30
Release date:2023-05-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
8FBQ
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Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b
Descriptor: 1-[(3M)-3-{3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]pyridin-2-yl}phenyl]piperazine, ACETATE ION, CHLORIDE ION, ...
Authors:Fenwick, M.K, Staker, B.L, Lovell, S.W, Phan, I.Q, Early, J, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-29
Release date:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.
Nat Commun, 14, 2023
8FBM
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BU of 8fbm by Molmil
Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and inhibitor 1
Descriptor: 2-chloro-5-[ethyl(phenyl)sulfamoyl]-N-[2-(2-oxopyrrolidin-1-yl)phenyl]benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Staker, B.L, Fenwick, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-11-29
Release date:2023-05-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
To Be Published
8HBS
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BU of 8hbs by Molmil
Crystal of rAlfNmt
Descriptor: Glycylpeptide N-tetradecanoyltransferase
Authors:Wang, Y, Wang, S.
Deposit date:2022-10-30
Release date:2023-03-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus.
Microbiol Spectr, 11, 2023
7RK3
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BU of 7rk3 by Molmil
Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
Descriptor: 4'-diphospho pantetheine, ADP-ribosylation factor 6, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Fenwick, M.K, Lin, H.
Deposit date:2021-07-21
Release date:2022-07-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
To Be Published
7OWO
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BU of 7owo by Molmil
HsNMT1 in complex with both MyrCoA and N-acetylated KSFSKPR peptide
Descriptor: COENZYME A, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWN
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BU of 7own by Molmil
HsNMT1 in complex with both MyrCoA and peptide AKSFSKPR
Descriptor: ALA-LYS-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWP
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BU of 7owp by Molmil
HsNMT1 in complex with both MyrCoA and ACE-G-(L-ORN)SFSKPR
Descriptor: ACE-GLY-ORN-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWU
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BU of 7owu by Molmil
HsNMT1 in complex with both CoA and Myr-ANCFSKPR peptide
Descriptor: ALA-ASN-CYS-PHE-SER-LYS-PRO-ARG, COENZYME A, GLYCEROL, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWM
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BU of 7owm by Molmil
HsNMT1 in complex with both MyrCoA and HCPA substrate peptide GKQNSKLR
Descriptor: GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, Neuron-specific calcium-binding protein hippocalcin, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWR
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BU of 7owr by Molmil
HsNMT1 in complex with both MyrCoA and peptide GGKSFSKPR
Descriptor: GLY-GLY-LYS-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWQ
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BU of 7owq by Molmil
HsNMT1 in complex with both MyrCoA and peptide N-Methylated-GNCFSKPR
Descriptor: Glycylpeptide N-tetradecanoyltransferase 1, MGY-ASN-CYS-PHE-SER-LYS-PRO-ARG, TETRADECANOYL-COA
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
6TW5
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BU of 6tw5 by Molmil
Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917
Descriptor: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Brannigan, J.A.
Deposit date:2020-01-12
Release date:2021-07-21
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917
To Be Published
6TW6
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BU of 6tw6 by Molmil
Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923
Descriptor: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Brannigan, J.A.
Deposit date:2020-01-12
Release date:2021-07-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923
To Be Published
6TW7
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BU of 6tw7 by Molmil
Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918
Descriptor: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, TETRADECANOYL-COA, ...
Authors:Brannigan, J.A.
Deposit date:2020-01-12
Release date:2021-07-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918
To Be Published
6TW8
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BU of 6tw8 by Molmil
Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917
Descriptor: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
Authors:Brannigan, J.A.
Deposit date:2020-01-12
Release date:2021-07-21
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917
To Be Published
6SKJ
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BU of 6skj by Molmil
DeltaC2 C-terminal truncation of HsNMT1 in complex with MyrCoA and GNCFSKPR substrates
Descriptor: Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ...
Authors:Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T.
Deposit date:2019-08-15
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020
6SK2
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BU of 6sk2 by Molmil
HsNMT1 in complex with both MyrCoA and Acetylated-GKSFSKPR peptide reveals N-terminal Lysine Myristoylation
Descriptor: Apoptosis-inducing factor 3, COENZYME A, GLYCEROL, ...
Authors:Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T.
Deposit date:2019-08-14
Release date:2020-03-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.90000653 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020
6SK8
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BU of 6sk8 by Molmil
DeltaC3 C-terminal truncation of HsNMT1 in complex with MyrCoA and GDCFSKPR substrates
Descriptor: Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ...
Authors:Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T.
Deposit date:2019-08-14
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020
6SJZ
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BU of 6sjz by Molmil
HsNMT1 in complex with both MyrCoA and Acetylated-GNCFSKPR substrates
Descriptor: Apoptosis-inducing factor 3, CHLORIDE ION, GLYCEROL, ...
Authors:Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T.
Deposit date:2019-08-14
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020
6SK3
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BU of 6sk3 by Molmil
C-terminal HsNMT1 deltaC3 truncation in complex with both MyrCoA and GNCFSKPR substrates
Descriptor: Apoptosis-inducing factor 3, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T.
Deposit date:2019-08-14
Release date:2020-03-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020

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PDB entries from 2024-03-13

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