1IIC
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYLCOA
Descriptor:PEPTIDE N-myristoyltransferase, TETRADECANOYL-COA
Authors:Farazi, T.A., Waksman, G., Gordon, J.I.
Deposit date:2001-04-22
Release date:2001-05-02
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
Biochemistry, 40, 2001
1IID
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE N-MYRISTOYLTRANSFERASE WITH BOUND S-(2-OXO)PENTADECYLCOA AND THE OCTAPEPTIDE GLYASKLA
Descriptor:Peptide N-myristoyltransferase, Octapeptide GLYASKLA, NICKEL (II) ION, ...
Authors:Farazi, T.A., Gordon, J.I., Waksman, G.
Deposit date:2001-04-22
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
Biochemistry, 40, 2001
1IYK
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CRYSTAL STRUCTURE OF CANDIDA ALBICANS N-MYRISTOYLTRANSFERASE WITH MYRISTOYL-COA AND PEPTIDIC INHIBITOR
Descriptor:MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, TETRADECANOYL-COA, [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE
Authors:Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.
Deposit date:2002-08-29
Release date:2002-12-30
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1IYL
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CRYSTAL STRUCTURE OF CANDIDA ALBICANS N-MYRISTOYLTRANSFERASE WITH NON-PEPTIDIC INHIBITOR
Descriptor:Myristoyl-CoA:Protein N-Myristoyltransferase, (1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRIDIN-3-YLMETHYL)-AMINO]-PROPOXY}-BENZOFURAN-2-YL)-METHANONE
Authors:Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.
Deposit date:2002-08-29
Release date:2002-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1NMT
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N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A
Descriptor:N-MYRISTOYL TRANSFERASE, GLYCEROL
Authors:Weston, S.A., Pauptit, R.A.
Deposit date:1997-12-11
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the anti-fungal target N-myristoyl transferase.
Nat.Struct.Biol., 5, 1998
1RXT
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CRYSTAL STRUCTURE OF HUMAN MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE.
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, SULFATE ION, COBALT (II) ION
Authors:Yang, J., Wang, Y., Frey, G., Abeles, R.H., Petsko, G.A., Ringe, D.
Deposit date:2003-12-18
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase
To be Published
2NMT
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MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS
Descriptor:MYRISTOYL-COA\:PROTEIN N-MYRISTOYLTRANSFERASE, S-(2-OXO)PENTADECYLCOA, [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE, ...
Authors:Fuetterer, K., Bhatnagar, R.S., Waksman, G.
Deposit date:1998-07-14
Release date:1999-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs.
Nat.Struct.Biol., 5, 1998
2P6E
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CRYSTAL STRUCTURES OF SACCHAROMYCES CEREVISIAE N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA
Descriptor:Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA
Authors:Wu, J., Ding, J.
Deposit date:2007-03-18
Release date:2007-06-12
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
J.Biol.Chem., 282, 2007
2P6F
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CRYSTAL STRUCTURES OF SACCHAROMYCES CEREVISIAE N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITORS
Descriptor:Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
Authors:Wu, J., Ding, J.
Deposit date:2007-03-18
Release date:2007-06-12
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
J.Biol.Chem., 282, 2007
2P6G
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CRYSTAL STRUCTURES OF SACCHAROMYCES CEREVISIAE N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITORS
Descriptor:Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL
Authors:Wu, J., Ding, J.
Deposit date:2007-03-18
Release date:2007-06-12
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
J.Biol.Chem., 282, 2007
2WSA
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND (DDD85646)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Authors:Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G., Structural Genomics Consortium (SGC)
Deposit date:2009-09-04
Release date:2010-03-23
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.
Nature, 464, 2010
2WUU
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STRUCTURE OF N-MYRISTOYLTRANSFERASE FROM L. DONOVANI
Descriptor:N-MYRISTOYLTRANSFERASE, 2-oxopentadecyl-CoA
Authors:Brannigan, J.A., Smith, B.A., Yu, Z., Hodgkinson, M.R., Leatherbarrow, R.J., Tate, E.W., Brzozowski, A.M., Smith, D.F., Wilkinson, A.J.
Deposit date:2009-10-09
Release date:2009-12-01
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:N-Myristoyltransferase from Leishmania Donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis.
J.Mol.Biol., 396, 2010
2YNC
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH YNC12-COA THIOESTER.
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, TETRADEC-13-YNOIC ACID - COA THIOESTER, ...
Authors:Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.
Deposit date:2012-10-13
Release date:2014-01-15
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
2YND
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRAZOLE SULPHONAMIDE INHIBITOR.
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, 2-oxopentadecyl-CoA, ...
Authors:Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.
Deposit date:2012-10-13
Release date:2014-01-15
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
2YNE
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A BENZOTHIOPHENE INHIBITOR
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, 2-oxopentadecyl-CoA, ...
Authors:Wright, M.H., Clough, B., Rackham, M.D., Brannigan, J.A., Grainger, M., Bottrill, A.R., Heal, W.P., Broncel, M., Serwa, R.A., Mann, D., Leatherbarrow, R.J., Wilkinson, A.J., Holder, A.A., Tate, E.W.
Deposit date:2012-10-13
Release date:2014-01-15
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
3H5Z
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA
Descriptor:Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 1,2-ETHANEDIOL, ...
Authors:Qiu, W., Hutchinson, A., Lin, Y.-H., Wernimont, A., Mackenzie, F., Ravichandran, M., Cossar, D., Zhao, Y., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Ferguson, M.A.J., Fairlamb, A.H., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2009-04-22
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature, 464, 2010
3IU1
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA
Authors:Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2009-08-29
Release date:2009-09-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA
To be Published
3IU2
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD90096
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, (2R)-2-{4-hydroxy-5-methoxy-2-[3-(4-methylpiperazin-1-yl)propyl]phenyl}-3-pyridin-3-yl-1,3-thiazolidin-4-one
Authors:Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2009-08-29
Release date:2009-09-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096
To be Published
3IWE
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD85646
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Authors:Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2009-09-02
Release date:2009-09-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646
To be Published
3JTK
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CRYSTAL STRUCTURE OF HUMAN TYPE-I N-MYRISTOYLTRANSFERASE WITH BOUND MYRISTOYL-COA AND INHIBITOR DDD90055
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, (2R)-3-benzyl-2-(2-bromo-4-hydroxy-5-methoxyphenyl)-1,3-thiazolidin-4-one
Authors:Qiu, W., Hutchinson, A., Wernimont, A., Lin, Y.-H., Kania, A., Ravichandran, M., Kozieradzki, I., Cossar, D., Schapira, M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Wyatt, P.G., Ferguson, M.A.J., Frearson, J.A., Brand, S.Y., Robinson, D.A., Bochkarev, A., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2009-09-12
Release date:2009-09-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055
To be Published
4A2Z
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 4-METHOXY-2,3,6-TRIMETHYL-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, ...
Authors:Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A30
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, CHLORIDE ION, GLYCEROL, ...
Authors:Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A31
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 6-{[2-(4-METHYLPIPERAZIN-1-YL)ETHYL]AMINO}-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)PYRIDINE-3-SULFONAMIDE, ...
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A32
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 3,5-DICHLORO-3'-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE, ...
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
4A33
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA
Authors:Robinson, D.A., Brand, S., Cleghorn, L.A.T., McElroy, S.P., Smith, V.C., Hallyburton, I., Harrison, J.R., Norcross, N.R., Norval, S., Spinks, D., Stojanovski, L., Torrie, L.S., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A.J., Read, K.D., Wyatt, P.G., Gilbert, I.H.
Deposit date:2011-09-29
Release date:2011-12-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55, 2012
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