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2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
Descriptor: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
Descriptor: CALCIUM ION, CBL
Authors:Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
Deposit date:1999-01-06
Release date:1999-04-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
1YVH
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BU of 1yvh by Molmil
Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
Descriptor: 13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
Authors:Hu, J, Hubbard, S.R.
Deposit date:2005-02-15
Release date:2005-03-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
3BUN
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BU of 3bun by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
Descriptor: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUX
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BU of 3bux by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met
Descriptor: 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUM
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BU of 3bum by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
Descriptor: E3 ubiquitin-protein ligase CBL, Protein sprouty homolog 2
Authors:Ng, C, Jackson, A.R, Buschdorf, P.J, Sun, Q, Guy, R.G, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUW
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BU of 3buw by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
Descriptor: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUO
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BU of 3buo by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Descriptor: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3OB1
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BU of 3ob1 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide
Descriptor: 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q, Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OB2
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BU of 3ob2 by Molmil
Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
Descriptor: 12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q, Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OP0
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BU of 3op0 by Molmil
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
Descriptor: Epidermal growth factor receptor, NICKEL (II) ION, SODIUM ION, ...
Authors:Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
3PFV
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BU of 3pfv by Molmil
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Descriptor: 1,2-ETHANEDIOL, 11-meric peptide from Epidermal growth factor receptor, CHLORIDE ION, ...
Authors:Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Muniz, J.R.C, Vollmar, M, Canning, P, Gileadi, O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-10-29
Release date:2010-12-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published
3PLF
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BU of 3plf by Molmil
Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain
Descriptor: CALCIUM ION, CHLORIDE ION, E3 ubiquitin-protein ligase CBL, ...
Authors:Sun, Q, Sivaraman, J.
Deposit date:2010-11-15
Release date:2010-12-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
2Y1M
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BU of 2y1m by Molmil
Structure of native c-Cbl
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION
Authors:Dou, H, Sibbet, G.J, Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
2Y1N
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BU of 2y1n by Molmil
Structure of c-Cbl-ZAP-70 peptide complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ...
Authors:Dou, H, Sibbet, G.J, Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
3VGO
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BU of 3vgo by Molmil
Crystal structure of the N-terminal fragment of Cbl-b
Descriptor: E3 ubiquitin-protein ligase CBL-B
Authors:Kobashigawa, Y, Noda, N.N, Inagaki, F.
Deposit date:2011-08-18
Release date:2011-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Proc.Natl.Acad.Sci.USA, 108, 2011
4A4B
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BU of 4a4b by Molmil
Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
Authors:Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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BU of 4a4c by Molmil
Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, ...
Authors:Dou, H, Buetow, L, Hock, A, Sibbet, G.J, Vousden, K.H, Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
3VRP
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BU of 3vrp by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide
Descriptor: CALCIUM ION, Epidermal growth factor receptor, Signal transduction protein CBL-C
Authors:Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRN
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BU of 3vrn by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c
Descriptor: CALCIUM ION, Signal transduction protein CBL-C
Authors:Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c
J.Biochem., 152, 2012
3VRR
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BU of 3vrr by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide
Descriptor: CALCIUM ION, Epidermal growth factor receptor, Signal transduction protein CBL-C
Authors:Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRQ
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BU of 3vrq by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant)
Descriptor: CALCIUM ION, Signal transduction protein CBL-C
Authors:Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRO
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BU of 3vro by Molmil
Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-Src peptide
Descriptor: CALCIUM ION, Proto-oncogene tyrosine-protein kinase Src, Signal transduction protein CBL-C
Authors:Takeshita, K, Tezuka, T, Isozaki, Y, Yamashita, E, Suzuki, M, Yamanashi, Y, Yamamoto, T, Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
4GPL
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BU of 4gpl by Molmil
Structure of Cbl(TKB) bound to a phosphorylated pentapeptide
Descriptor: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL
Authors:Borgstahl, G, Natarajan, A.
Deposit date:2012-08-21
Release date:2013-09-18
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides.
Sci Rep, 3, 2013

 

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