1GX1
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE
Descriptor:2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ...
Authors:Kemp, L.E., Bond, C.S., Hunter, W.N.
Deposit date:2002-03-26
Release date:2002-04-03
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Essential Enzyme for Isoprenoid Biosynthesis and Target for Antimicrobial Drug Development
Proc.Natl.Acad.Sci.USA, 99, 2002
1H47
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STRUCTURES OF MECP SYNTHASE IN COMPLEX WITH (I) CMP AND (II) CMP AND PRODUCT
Descriptor:2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, GERANYL DIPHOSPHATE, ZINC ION, ...
Authors:Kemp, L.E., Alphey, M.S., Bond, C.S., Hunter, W.N.
Deposit date:2003-02-24
Release date:2004-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods
Acta Crystallogr.,Sect.D, 61, 2005
1H48
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THE STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE IN COMPLEX WITH CMP AND PRODUCT
Descriptor:2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, ZINC ION, ...
Authors:Kemp, L.E., Alphey, M.S., Bond, C.S., Hunter, W.N.
Deposit date:2003-02-24
Release date:2004-12-22
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods
Acta Crystallogr.,Sect.D, 61, 2005
1IV1
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Authors:Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Terada, T., Sirouzu, M., Yokoyama, S., Tame, J.R.H., Park, S.-Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-11
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
1IV2
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (BOUND FORM CDP)
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MAGNESIUM ION, CYTIDINE-5'-DIPHOSPHATE
Authors:Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Terada, T., Sirouzu, M., Yokoyama, S., Tame, J.R.H., Park, S.-Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-11
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
1IV3
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (BOUND FORM MG ATOMS)
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MAGNESIUM ION
Authors:Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Terada, T., Sirouzu, M., Yokoyama, S., Tame, J.R.H., Park, S.-Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-11
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
1IV4
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (BOUND FORM SUBSTRATE)
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MAGNESIUM ION, CYTIDINE-5'-MONOPHOSPHATE
Authors:Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Terada, T., Sirouzu, M., Yokoyama, S., Tame, J.R.H., Park, S.-Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-03-11
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Acta Crystallogr.,Sect.D, 59, 2003
1JN1
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE FROM HAEMOPHILUS INFLUENZAE (HI0671)
Descriptor:2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, COBALT (II) ION, SULFATE ION
Authors:Lehmann, C., Lim, K., Toedt, J., Krajewski, W., Howard, A., Eisenstein, E., Herzberg, O., Structure 2 Function Project (S2F)
Deposit date:2001-07-21
Release date:2002-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: activation by conformational transition.
Proteins, 49, 2002
1JY8
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2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF)
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hecht, S., Eisenreich, W., Gerhardt, S., Bacher, A., Rohdich, F.
Deposit date:2001-09-11
Release date:2002-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.
J.Mol.Biol., 316, 2002
1KNJ
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CO-CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS, COMPLEXED WITH CMP/MECDP/MN2+
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1KNK
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1T0A
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE FROM SHEWANELLA ONEIDENSIS
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, COBALT (II) ION, ...
Authors:Ni, S., Robinson, H., Marsing, G.C., Bussiere, D.E., Kennedy, M.A.
Deposit date:2004-04-08
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.
Acta Crystallogr.,Sect.D, 60, 2004
1U3L
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ISPF WITH MG AND CDP
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MAGNESIUM ION, ZINC ION, ...
Authors:Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hechst, S., Eisenreich, W., Gerhardt, S., Bacher, A., Rohdich, F.
Deposit date:2004-07-22
Release date:2004-08-31
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids
J.Mol.Biol., 316, 2002
1U3P
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ISPF NATIVE
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION
Authors:Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hecht, S., Eisenreich, W., Gerhardt, S., Bacher, A., Rohdich, F.
Deposit date:2004-07-22
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids
J.Mol.Biol., 316, 2002
1U40
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ISPF WITH 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL
Authors:Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hecht, S., Eisenreich, W., Gerhardt, S., Bacher, A., Rohdich, F.
Deposit date:2004-07-23
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids
J.Mol.Biol., 316, 2002
1U43
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ISPF WITH 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL 2-PHOSPHATE
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL 2-PHOSPHATE
Authors:Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hecht, S., Eisenreich, W., Gerhardt, S., Bacher, A., Rohdich, F.
Deposit date:2004-07-23
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate Independent Biosynthesis of Isoprenoids
J.Mol.Biol., 316, 2002
1VH8
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CRYSTAL STRUCTURE OF A 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, PYROPHOSPHATE 2-, ACETIC ACID
Authors:Structural GenomiX
Deposit date:2003-12-01
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VHA
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION, ACETIC ACID, ...
Authors:Structural GenomiX
Deposit date:2003-12-01
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1YQN
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E. COLI ISPF DOUBLE MUTANT
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, MANGANESE (II) ION, ...
Authors:Sgraja, T., Kemp, L.E., Ramsden, N., Hunter, W.N.
Deposit date:2005-02-02
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.
Acta Crystallogr.,Sect.F, 61, 2005
2AMT
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH A CDP DERIVED FLUORESCENT INHIBITOR
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-O-[({[(2-{[(2-AMINOPHENYL)CARBONYL]OXY}ETHYL)OXY]PHOSPHINATO}OXY)PHOSPHINATO]CYTIDINE, ...
Authors:Ramsden, N.L., Hunter, W.N.
Deposit date:2005-08-10
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fluorescent Inhibitors for IspF, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy.
Angew.Chem.Int.Ed.Engl., 45, 2006
2GZL
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH A CDP DERIVED FLUORESCENT INHIBITOR
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-O-{[({[2-({[5-(DIMETHYLAMINO)NAPHTHALEN-1-YL]SULFONYL}AMINO)ETHYL]OXY}PHOSPHINATO)OXY]PHOSPHINATO}CYT, ...
Authors:Crane, C.M., Kaiser, J., Ramsden, N.L., Lauw, S., Rohdich, F., Wolfgang, E., Hunter, W.N., Bacher, A., Diederich, F.
Deposit date:2006-05-11
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fluorescent Inhibitors for Ispf, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy.
Angew.Chem.Int.Ed.Engl., 45, 2006
2PMP
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STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE FROM THE ISOPRENOID BIOSYNTHETIC PATHWAY OF ARABIDOPSIS THALIANA
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, PHOSPHATE ION, ...
Authors:Calisto, B.M., Perez-Gil, J., Querol-Audi, J., Fita, I., Imperial, S.
Deposit date:2007-04-23
Release date:2007-09-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biosynthesis of isoprenoids in plants: Structure of the 2C-methyl-D-erithrytol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes.
Protein Sci., 16, 2007
2UZH
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MYCOBACTERIUM SMEGMATIS 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF)
Descriptor:2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ...
Authors:Buetow, L., Brown, A.C., Parish, T., Hunter, W.N.
Deposit date:2007-04-27
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
Bmc Struct.Biol., 7, 2007
3B6N
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE PV003920 FROM PLASMODIUM VIVAX
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION
Authors:Wernimont, A.K., Lew, J., Kozieradzki, I., Lin, Y.H., Sun, X., Khuu, C., Zhao, Y., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bochkarev, A., Hui, R., Artz, J.D., Xiao, T., Structural Genomics Consortium (SGC)
Deposit date:2007-10-29
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase PV003920 from Plasmodium vivax.
To be Published
3ELC
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH LIGAND
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one, ...
Authors:Hunter, W.N., Ramsden, N.L., Ulaganathan, V.
Deposit date:2008-09-22
Release date:2009-08-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
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