1A4H
  • Download 1a4h
  • View 1a4h
Molmil generated image of 1a4h
STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
Descriptor:HEAT SHOCK PROTEIN 90, GELDANAMYCIN
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1998-01-29
Release date:1998-08-05
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AH6
  • Download 1ah6
  • View 1ah6
Molmil generated image of 1ah6
STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AH8
  • Download 1ah8
  • View 1ah8
Molmil generated image of 1ah8
STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AJ6
  • Download 1aj6
  • View 1aj6
Molmil generated image of 1aj6
NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION
Descriptor:GYRASE, NOVOBIOCIN
Authors:Weston, S.A., Tunnicliffe, A., Pauptit, R.A.
Deposit date:1997-05-15
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study.
Biochemistry, 36, 1997
1AM1
  • Download 1am1
  • View 1am1
Molmil generated image of 1am1
ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-20
Release date:1998-06-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AMW
  • Download 1amw
  • View 1amw
Molmil generated image of 1amw
ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-19
Release date:1998-06-24
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1BGQ
  • Download 1bgq
  • View 1bgq
Molmil generated image of 1bgq
RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, RADICICOL
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:1998-05-29
Release date:1999-06-08
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42, 1999
1BXD
  • Download 1bxd
  • View 1bxd
Molmil generated image of 1bxd
NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ
Descriptor:PROTEIN (ENVZ)
Authors:Tanaka, T., Saha, S.K., Tomomori, C., Ishima, R., Liu, D., Tong, K.I., Park, H., Dutta, R., Qin, L., Swindells, M.B., Yamazaki, T., Ono, A.M., Kainosho, M., Inouye, M., Ikura, M.
Deposit date:1998-10-02
Release date:1999-10-02
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ.
Nature, 396, 1998
1BYQ
  • Download 1byq
  • View 1byq
Molmil generated image of 1byq
HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG
Descriptor:PROTEIN (HEAT SHOCK PROTEIN 90)
Authors:Russo, A.A., Pavletich, N.P.
Deposit date:1998-10-19
Release date:1998-10-28
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
J.Cell Biol., 143, 1998
1ID0
  • Download 1id0
  • View 1id0
Molmil generated image of 1id0
CRYSTAL STRUCTURE OF THE NUCLEOTIDE BOND CONFORMATION OF PHOQ KINASE DOMAIN
Descriptor:PHOQ HISTIDINE KINASE (E.C.2.7.1.37 )
Authors:Marina, A., Mott, C., Auyzenberg, A., Waldburger, C.D., Hendrickson, W.A.
Deposit date:2001-04-02
Release date:2001-10-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.
J.Biol.Chem., 276, 2001
1KZN
  • Download 1kzn
  • View 1kzn
Molmil generated image of 1kzn
CRYSTAL STRUCTURE OF E. COLI 24KDA DOMAIN IN COMPLEX WITH CLOROBIOCIN
Descriptor:DNA GYRASE SUBUNIT B (E.C.5.99.1.3)
Authors:Lafitte, D., Lamour, V., Tsvetkov, P.O., Makarov, A.A., Klich, M., Deprez, P., Moras, D., Briand, C., Gilli, R.
Deposit date:2002-02-07
Release date:2002-06-19
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
Biochemistry, 41, 2002
1OSF
  • Download 1osf
  • View 1osf
Molmil generated image of 1osf
HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN
Descriptor:heat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha, 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN
Authors:Jez, J.M., Chen, J.C.-H., Rastelli, G., Stroud, R.M., Santi, D.V.
Deposit date:2003-03-19
Release date:2003-05-27
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90
Chem.Biol., 10, 2003
1QY5
  • Download 1qy5
  • View 1qy5
Molmil generated image of 1qy5
CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH THE SPECIFIC LIGAND NECA
Descriptor:Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2003-09-09
Release date:2003-11-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
1QY8
  • Download 1qy8
  • View 1qy8
Molmil generated image of 1qy8
CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH RADICICOL
Descriptor:Endoplasmin
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2003-09-09
Release date:2003-11-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
1QYE
  • Download 1qye
  • View 1qye
Molmil generated image of 1qye
CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH 2-CHLORODIDEOXYADENOSINE
Descriptor:Endoplasmin
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2003-09-10
Release date:2003-11-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation
J.Biol.Chem., 278, 2003
1R62
  • Download 1r62
  • View 1r62
Molmil generated image of 1r62
CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE TWO-COMPONENT SYSTEM TRANSMITTER PROTEIN NRII (NTRB)
Descriptor:Nitrogen regulation protein NR(II) (E.C.2.7.3.-)
Authors:Song, Y., Peisach, D., Pioszak, A.A., Xu, Z., Ninfa, A.J.
Deposit date:2003-10-14
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the C-terminal Domain of the Two-Component System Transmitter Protein Nitrogen Regulator II (NRII; NtrB), Regulator of Nitrogen Assimilation in Escherichia coli.
Biochemistry, 43, 2004
1TBW
  • Download 1tbw
  • View 1tbw
Molmil generated image of 1tbw
LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC0
  • Download 1tc0
  • View 1tc0
Molmil generated image of 1tc0
LIGAND INDUCED CONFORMATIONAL SHIFTS IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION COMPLEXED WITH THE PHYSIOLOGICAL PARTNER ATP
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1TC6
  • Download 1tc6
  • View 1tc6
Molmil generated image of 1tc6
LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION ADP-COMPLEX
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L.
Deposit date:2004-05-20
Release date:2004-08-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
1U0Y
  • Download 1u0y
  • View 1u0y
Molmil generated image of 1u0y
N-DOMAIN OF GRP94, WITH THE CHARGED DOMAIN, IN COMPLEX WITH THE NOVEL LIGAND N-PROPYL CARBOXYAMIDO ADENOSINE
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
TO BE PUBLISHED
1U0Z
  • Download 1u0z
  • View 1u0z
Molmil generated image of 1u0z
N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH RADICICOL
Descriptor:Endoplasmin precursor
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol
TO BE PUBLISHED
1U2O
  • Download 1u2o
  • View 1u2o
Molmil generated image of 1u2o
CRYSTAL STRUCTURE OF THE N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH NECA
Descriptor:Endoplasmin
Authors:Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T.
Deposit date:2004-07-19
Release date:2004-08-03
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
1UY6
  • Download 1uy6
  • View 1uy6
Molmil generated image of 1uy6
HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UY7
  • Download 1uy7
  • View 1uy7
Molmil generated image of 1uy7
HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(4-METHOXY-BENZYL)-9H-PURIN-6-YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
1UY8
  • Download 1uy8
  • View 1uy8
Molmil generated image of 1uy8
HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3-TRIMETHOXY-BENZYL)-9H-PURIN-6YLAMINE
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E.
Deposit date:2004-03-02
Release date:2004-07-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2017 Protein Data Bank Japan