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5BV7
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BU of 5bv7 by Molmil
Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 27C3 heavy chain, 27C3 light chain, ...
Authors:Piper, D.E, Romanow, W.G, Thibault, S.T, Walker, N.P.C.
Deposit date:2015-06-04
Release date:2015-12-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
J.Biol.Chem., 291, 2016
5TXF
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BU of 5txf by Molmil
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Phosphatidylcholine-sterol acyltransferase, ...
Authors:Manthei, K.A, Glukhova, A, Tesmer, J.J.G.
Deposit date:2016-11-16
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
J. Biol. Chem., 292, 2017
7X2P
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BU of 7x2p by Molmil
Legionella pneumophila effector RavL
Descriptor: Putative lipase
Authors:Zheng, J, Lu, Z, Chen, S.
Deposit date:2022-02-26
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Legionella pneumophila effector RavL
To Be Published
4X94
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BU of 4x94 by Molmil
Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Group XV phospholipase A2, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X90
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BU of 4x90 by Molmil
Crystal structure of Lysosomal Phospholipase A2
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
6MTW
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BU of 6mtw by Molmil
Lysosomal Phospholipase A2 in complex with Zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Group XV phospholipase A2, ...
Authors:Bouley, R, Tesmer, J.J.G.
Deposit date:2018-10-22
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis of Lysosomal Phospholipase A2Inhibition by Zn2.
Biochemistry, 58, 2019
6MVD
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BU of 6mvd by Molmil
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-{4-[(4R)-4-hydroxy-6-oxo-4-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-yl]piperidin-1-yl}-4-(trifluoromethyl)pyridine-3-carbonitrile, NICKEL (II) ION, ...
Authors:Manthei, K.A, Chang, L, Tesmer, J.J.G.
Deposit date:2018-10-25
Release date:2018-12-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Elife, 7, 2018
4X91
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BU of 4x91 by Molmil
Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X93
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BU of 4x93 by Molmil
Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X92
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BU of 4x92 by Molmil
Crystal structure of Lysosomal Phospholipase A2-S165A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Group XV phospholipase A2
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X96
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BU of 4x96 by Molmil
Low resolution crystal structure of Lecithin:Cholesterol Acyltransferase (LCAT; residues 21-397)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Phosphatidylcholine-sterol acyltransferase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (8.69 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X95
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BU of 4x95 by Molmil
Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Group XV phospholipase A2, METHYL ARACHIDONYL FLUOROPHOSPHONATE, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X97
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BU of 4x97 by Molmil
Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Glukhova, A, Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4XX1
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BU of 4xx1 by Molmil
Low resolution structure of LCAT in complex with Fab1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab1 heavy chain, Fab1 light chain, ...
Authors:Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T.
Deposit date:2015-01-29
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The high-resolution crystal structure of human LCAT.
J.Lipid Res., 56, 2015
4XWG
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BU of 4xwg by Molmil
Crystal Structure of LCAT (C31Y) in complex with Fab1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab1 Heavy Chain, Fab1 Light Chain, ...
Authors:Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T.
Deposit date:2015-01-28
Release date:2015-07-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The high-resolution crystal structure of human LCAT.
J.Lipid Res., 56, 2015

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