4X90
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X91
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2 IN COMPLEX WITH ISOPROPYL DODEC-11-ENYLFLUOROPHOSPHONATE (IDFP)
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, propan-2-yl (R)-tridec-12-en-1-ylphosphonofluoridate, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X92
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2-S165A
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X93
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2 CRYSTALLIZED IN THE PRESENCE OF METHYL ARACHIDONYL FLUOROPHOSPHONATE (TETRAGONAL FORM)
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X94
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2 CRYSTALLIZED IN THE PRESENCE OF METHYL ARACHIDONYL FLUOROPHOSPHONATE (HEXAGONAL FORM)
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X95
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CRYSTAL STRUCTURE OF FULLY GLYCOSYLATED LYSOSOMAL PHOSPHOLIPASE A2 IN COMPLEX WITH METHYL ARACHIDONYL FLUOROPHOSPHONATE (MAFP)
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X96
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LOW RESOLUTION CRYSTAL STRUCTURE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT; RESIDUES 21-397)
Descriptor:Phosphatidylcholine-sterol acyltransferase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (8.69 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4X97
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CRYSTAL STRUCTURE OF LYSOSOMAL PHOSPHOLIPASE A2 IN COMPLEX WITH METHYL ARACHIDONYL FLUOROPHOSPHONATE (MAFP)
Descriptor:Group XV phospholipase A2, N-ACETYL-D-GLUCOSAMINE, METHYL ARACHIDONYL FLUOROPHOSPHONATE, ...
Authors:Glukhova, A., Tesmer, J.J.G.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Nat Commun, 6, 2015
4XWG
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CRYSTAL STRUCTURE OF LCAT (C31Y) IN COMPLEX WITH FAB1
Descriptor:Fab1 Light Chain, Fab1 Heavy Chain, Phosphatidylcholine-sterol acyltransferase, ...
Authors:Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T.
Deposit date:2015-01-28
Release date:2015-07-29
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The high-resolution crystal structure of human LCAT.
J.Lipid Res., 56, 2015
4XX1
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LOW RESOLUTION STRUCTURE OF LCAT IN COMPLEX WITH FAB1
Descriptor:Fab1 light chain, Fab1 heavy chain, Phosphatidylcholine-sterol acyltransferase, ...
Authors:Piper, D.E., Walker, N.P.C., Romanow, W.G., Thibault, S.T.
Deposit date:2015-01-29
Release date:2015-07-29
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The high-resolution crystal structure of human LCAT.
J.Lipid Res., 56, 2015
5BV7
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CRYSTAL STRUCTURE OF HUMAN LCAT (L4F, N5D) IN COMPLEX WITH FAB OF AN AGONISTIC ANTIBODY
Descriptor:Phosphatidylcholine-sterol acyltransferase, 27C3 light chain, 27C3 heavy chain, ...
Authors:Piper, D.E., Romanow, W.G., Thibault, S.T., Walker, N.P.C.
Deposit date:2015-06-04
Release date:2015-12-16
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
J.Biol.Chem., 291, 2016
5TXF
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CRYSTAL STRUCTURE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN A CLOSED CONFORMATION
Descriptor:Phosphatidylcholine-sterol acyltransferase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Manthei, K.A., Glukhova, A., Tesmer, J.J.G.
Deposit date:2016-11-16
Release date:2017-10-25
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
J. Biol. Chem., 292, 2017
6DTJ
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CRYSTAL STRUCTURE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN COMPLEX WITH ISOPROPYL DODEC-11-ENYLFLUOROPHOSPHONATE (IDFP) AND A SMALL MOLECULE ACTIVATOR
Descriptor:Phosphatidylcholine-sterol acyltransferase, N-ACETYL-D-GLUCOSAMINE, propan-2-yl hydrogen (R)-ethylphosphonate, ...
Authors:Manthei, K.A., Chang, L., Tesmer, J.J.G.
Deposit date:2018-06-16
Release date:2018-10-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
Biorxiv, 2018
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