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8OOI
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BU of 8ooi by Molmil
Full composite cryo-EM map of p97/VCP in ADP.Pi state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Cheng, T.C, Sakata, E, Schuetz, A.K.
Deposit date:2023-04-05
Release date:2024-01-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Nat.Chem., 16, 2024
8HRZ
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BU of 8hrz by Molmil
Crystal structure of the p97-N/D1 hexamer in complex with six p47-UBX domains
Descriptor: ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase
Authors:Nguyen, T.Q, Kang, W.
Deposit date:2022-12-16
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the p97-N/D1 hexmaer in complex with six p47-UBX domains
To Be Published
8FCP
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BU of 8fcp by Molmil
Cryo-EM structure of p97:UBXD1 para state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCO
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BU of 8fco by Molmil
Cryo-EM structure of p97:UBXD1 meta state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCQ
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BU of 8fcq by Molmil
Cryo-EM structure of p97:UBXD1 PUB-in state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCN
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BU of 8fcn by Molmil
Cryo-EM structure of p97:UBXD1 VIM-only state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCT
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BU of 8fct by Molmil
Cryo-EM structure of p97:UBXD1 lariat mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCL
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BU of 8fcl by Molmil
Cryo-EM structure of p97:UBXD1 closed state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCR
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BU of 8fcr by Molmil
Cryo-EM structure of p97:UBXD1 H4-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCM
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BU of 8fcm by Molmil
Cryo-EM structure of p97:UBXD1 open state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8HL7
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BU of 8hl7 by Molmil
Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kang, W, Yang, J.K.
Deposit date:2022-11-29
Release date:2023-07-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase.
Iscience, 26, 2023
8B5R
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BU of 8b5r by Molmil
p97-p37-SPI substrate complex
Descriptor: I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ...
Authors:van den Boom, J, Marini, G, Meyer, H, Saibil, H.
Deposit date:2022-09-24
Release date:2023-06-07
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural basis of ubiquitin-independent PP1 complex disassembly by p97.
Embo J., 42, 2023
7Y59
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BU of 7y59 by Molmil
The cryo-EM structure of human ERAD retro-translocation complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Derlin-1, ...
Authors:Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y.
Deposit date:2022-06-16
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (4.51 Å)
Cite:The cryo-EM structure of the human ERAD retrotranslocation complex.
Sci Adv, 9, 2023
7Y4W
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BU of 7y4w by Molmil
The cryo-EM structure of human ERAD retro-translocation complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase
Authors:Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y.
Deposit date:2022-06-16
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:The cryo-EM structure of the human ERAD retrotranslocation complex.
Sci Adv, 9, 2023
7Y53
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BU of 7y53 by Molmil
The cryo-EM structure of human ERAD retro-translocation complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase
Authors:Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y.
Deposit date:2022-06-16
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:The cryo-EM structure of the human ERAD retrotranslocation complex.
Sci Adv, 9, 2023
8DAT
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BU of 8dat by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intB)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAU
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BU of 8dau by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two folded ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (uA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAV
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BU of 8dav by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uC)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAW
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BU of 8daw by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uD)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAS
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BU of 8das by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAR
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BU of 8dar by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex unbound but in the presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
Authors:Lee, H.G, Lima, C.D.
Deposit date:2022-06-14
Release date:2022-11-30
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
7WUB
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BU of 7wub by Molmil
Cryo-EM structure of dodecamer P97
Descriptor: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Liu, S, Wang, T.
Deposit date:2022-02-08
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structure of dodecamer P97 at 2.99 Angstroms resolution
To Be Published
7PUX
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BU of 7pux by Molmil
Structure of p97 N-D1(L198W) in complex with Fragment TROLL2
Descriptor: (1S)-2-amino-1-(4-bromophenyl)ethan-1-ol, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bothe, S, Schindelin, H.
Deposit date:2021-10-01
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
Commun Chem, 5, 2022
7VCX
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BU of 7vcx by Molmil
Human p97 single hexamer conformer II with ATPgammaS bound
Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Gao, H, Li, F, Shi, Z, Li, Y, Yu, H.
Deposit date:2021-09-04
Release date:2022-03-02
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
7VCT
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BU of 7vct by Molmil
Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Gao, H, Li, F, Shi, Z, Li, Y, Yu, H.
Deposit date:2021-09-04
Release date:2022-03-02
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022

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PDB entries from 2024-03-27

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