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6WMW
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BU of 6wmw by Molmil
GFRAL receptor bound with two antibody Fabs (3P10, 25M22)
Descriptor: FAB25M22 heavy chain fragment, FAB25M22 light chain, FAB3P10 heavy chain fragment, ...
Authors:White, A, Lakshminarasimhan, D, Olland, A, Suto, R.K.
Deposit date:2020-04-21
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Nat Med, 26, 2020
1Q8D
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BU of 1q8d by Molmil
The crystal structure of GDNF family co-receptor alpha 1 domain 3
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GDNF family receptor alpha 1
Authors:Leppanen, V.M, Bespalov, M.M, Runeberg-Roos, P, Puurand, U, Merits, A, Saarma, M, Goldman, A.
Deposit date:2003-08-21
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation.
Embo J., 23, 2004
3FUB
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BU of 3fub by Molmil
Crystal structure of GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Parkash, V, Goldman, A.
Deposit date:2009-01-14
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling
Acta Crystallogr.,Sect.F, 65, 2009
2V5E
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BU of 2v5e by Molmil
The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.
Descriptor: 1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A.
Deposit date:2008-10-03
Release date:2008-10-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.
J.Biol.Chem., 283, 2008
4UX8
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BU of 4ux8 by Molmil
RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ...
Authors:Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q.
Deposit date:2014-08-19
Release date:2014-10-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association.
Cell Rep., 8, 2014
6GL7
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BU of 6gl7 by Molmil
Neurturin-GFRa2-RET extracellular complex
Descriptor: GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret
Authors:Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A.
Deposit date:2018-05-23
Release date:2019-08-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Sci Adv, 5, 2019
7RHQ
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BU of 7rhq by Molmil
Cryo-EM structure of Xenopus Patched-1 in complex with GAS1 and Sonic Hedgehog
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huang, P, Lian, T, Wierbowski, B, Garcia-Linares, S, Jiang, J, Salic, A.
Deposit date:2021-07-18
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
Dev.Cell, 57, 2022
2GH0
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BU of 2gh0 by Molmil
Growth factor/receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, X.Q.
Deposit date:2006-03-24
Release date:2006-06-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
8OS6
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BU of 8os6 by Molmil
Structure of a GFRA1/GDNF LICAM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Houghton, F.M, Adams, S.E, Briggs, D.C, McDonald, N.Q.
Deposit date:2023-04-18
Release date:2023-11-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Architecture and regulation of a GDNF-GFR alpha 1 synaptic adhesion assembly.
Nat Commun, 14, 2023
5VZ4
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BU of 5vz4 by Molmil
Receptor-growth factor crystal structure at 2.20 Angstrom resolution
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, GDNF family receptor alpha-like, ...
Authors:Lakshminarasimhan, D, White, A, Suto, R.K.
Deposit date:2017-05-26
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
7AB8
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BU of 7ab8 by Molmil
Crystal structure of a GDNF-GFRalpha1 complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-09-07
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
7AML
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BU of 7aml by Molmil
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ...
Authors:Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q.
Deposit date:2020-10-09
Release date:2021-01-13
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
Structure, 29, 2021
5MR4
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BU of 5mr4 by Molmil
Ligand-receptor complex.
Descriptor: DI(HYDROXYETHYL)ETHER, FORMIC ACID, GDNF family receptor alpha-2, ...
Authors:Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
5MR5
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BU of 5mr5 by Molmil
Ligand-receptor complex.
Descriptor: GDNF family receptor alpha-2, GLYCEROL, Neurturin, ...
Authors:Sandmark, J, Oster, L, Aagaard, A, Roth, R, Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
6Q2R
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BU of 6q2r by Molmil
Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ...
Authors:Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2J
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BU of 6q2j by Molmil
Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-like, ...
Authors:Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2S
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BU of 6q2s by Molmil
Cryo-EM structure of RET/GFRa3/ARTN extracellular complex. The 3D refinement was applied with C2 symmetry.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-3, ...
Authors:Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2O
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BU of 6q2o by Molmil
Cryo-EM structure of RET/GFRa2/NRTN extracellular complex. The 3D refinement was applied with C2 symmetry.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ...
Authors:Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2N
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BU of 6q2n by Molmil
Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
Descriptor: CALCIUM ION, GDNF family receptor alpha-1, Glial cell line-derived neurotrophic factor, ...
Authors:Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019

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