PDB: 49 resultsInfo pagesStatus searchChemie searchBIRD

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8QPC	18mer DNA mimic Foldamer with an Aromatic linker in complex with Sac7d V26A/M29A protein Descriptor: DNA-binding protein 7b, N-[2-(2-methyl-1,3-dioxolan-2-yl)phenyl]-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}pyridine-4-carboxamide Authors: Deepak, D, Corvaglia, V, Wu, J, Huc, I. Deposit date: 2023-10-01 Release date: 2023-11-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.24 Å) Cite: DNA-Mimic Foldamer Recognition of a Chromosomal Protein To Be Published
8Q2M	18mer DNA mimic Foldamer with an Aliphatic linker in complex with Sac7d V26A/M29A protein Descriptor: DNA mimic Foldamer, DNA-binding protein 7b Authors: Deepak, D, Corvaglia, V, Wu, J, Huc, I. Deposit date: 2023-08-02 Release date: 2023-08-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.21 Å) Cite: 18mer DNA mimic foldamer with Alphatic linker in complex with Sac7d wild protein. To Be Published
8CMN	18mer DNA mimic Foldamer with an aliphatic linker in complex with Sac7d wild protein Descriptor: DNA-binding protein 7d, N-[2-(2-methyl-1,3-dioxolan-2-yl)phenyl]-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}pyridine-4-carboxamide Authors: Deepak, D, Corvaglia, V, Wu, J, Huc, I. Deposit date: 2023-02-20 Release date: 2023-07-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.65 Å) Cite: 18mer DNA mimic Foldamer with an aliphatic linker in complex with Sac7d wild protein To Be Published
6VOY	Cryo-EM structure of HTLV-1 instasome Descriptor: DNA (25-MER), DNA (5'-D(P*AP*CP*AP*CP*AP*CP*TP*TP*GP*AP*CP*TP*AP*GP*GP*GP*TP*G)-3'), DNA-binding protein 7d, ... Authors: Bhatt, V, Shi, K, Sundborger, A, Aihara, H. Deposit date: 2020-02-01 Release date: 2020-07-01 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of host protein hijacking in human T-cell leukemia virus integration. Nat Commun, 11, 2020
6QBA	Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold Descriptor: 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Mlynek, G, Brey, C.U, Djinovic-Carugo, K, Puehringer, D. Deposit date: 2018-12-20 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proc.Natl.Acad.Sci.USA, 117, 2020
6V3K	Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ419 (compound 4c) Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... Authors: Lyumkis, D, Jozwik, I.K, Passos, D. Deposit date: 2019-11-25 Release date: 2020-02-12 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
6PUW	Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and Bictegravir (BIC) Descriptor: Bictegravir, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... Authors: Lyumkis, D, Jozwik, I.K, Passos, D. Deposit date: 2019-07-18 Release date: 2020-02-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
6PUZ	Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ446 (compound 4f) Descriptor: 4-azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... Authors: Lyumkis, D, Jozwik, I.K, Passos, D. Deposit date: 2019-07-18 Release date: 2020-02-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
6PUY	Structure of HIV cleaved synaptic complex (CSC) intasome bound with magnesium and INSTI XZ426 (compound 4d) Descriptor: 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide, Chimeric Sso7d and HIV-1 integrase, MAGNESIUM ION, ... Authors: Lyumkis, D, Jozwik, I.K, Passos, D. Deposit date: 2019-07-18 Release date: 2020-02-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
6PUT	Structure of HIV cleaved synaptic complex (CSC) intasome bound with calcium Descriptor: CALCIUM ION, Chimeric Sso7d and HIV-1 integrase, ZINC ION, ... Authors: Lyumkis, D, Jozwik, I.K, Passos, D. Deposit date: 2019-07-18 Release date: 2020-02-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science, 367, 2020
6J8W	Structure of MOEN5-SSO7D fusion protein in complex with lig 1 Descriptor: (2S)-3-dimethoxyphosphoryloxy-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid, MoeN5,DNA-binding protein 7d Authors: Ko, T.P, Zhang, L.L, Chen, C.C, Guo, R.T. Deposit date: 2019-01-21 Release date: 2019-04-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
6J8V	Structure of MOEN5-SSO7D fusion protein in complex with ligand 2 Descriptor: FARNESYL, MoeN5,DNA-binding protein 7d Authors: Ko, T.P, Zhang, L.L, Chen, C.C, Guo, R.T. Deposit date: 2019-01-21 Release date: 2019-04-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
5GWV	Structure of MoeN5-Sso7d fusion protein in complex with a substrate analogue Descriptor: (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid, MoeN5,DNA-binding protein 7d Authors: Ko, T.-P, Guo, R.-T, Chen, C.-C. Deposit date: 2016-09-14 Release date: 2017-09-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
5GWW	Structure of MoeN5-Sso7d fusion protein in complex with a permethylated substrate analogue Descriptor: MoeN5,DNA-binding protein 7d, methyl (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoate Authors: Ko, T.-P, Guo, R.-T, Chen, C.-C. Deposit date: 2016-09-14 Release date: 2017-09-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
5B0J	Structure of MoeN5-Sso7d fusion protein in complex with beta-undecyl maltoside Descriptor: MoeN5,DNA-binding protein 7d, UNDECYL-MALTOSIDE Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-10-30 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B0M	Structure of MoeN5-Sso7d fusion protein in complex with beta-dodecyl maltoside Descriptor: DODECYL-BETA-D-MALTOSIDE, MoeN5,DNA-binding protein 7d Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-11-02 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B0I	Structure of MoeN5-Sso7d fusion protein in complex with beta-octyl glucoside Descriptor: MoeN5,DNA-binding protein 7d, octyl beta-D-glucopyranoside Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-10-30 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B02	Structure of the prenyltransferase MoeN5 with a fusion protein tag of Sso7d Descriptor: MoeN5,DNA-binding protein 7d Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-10-27 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B03	Structure of MoeN5-Sso7d fusion protein in complex with geranyl pyrophosphate Descriptor: GERANYL DIPHOSPHATE, MoeN5,DNA-binding protein 7d Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-10-27 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B0L	Structure of MoeN5-Sso7d fusion protein in complex with beta-nonyl glucoside Descriptor: MoeN5,DNA-binding protein 7d, nonyl beta-D-glucopyranoside Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T, Oldfield, E.O. Deposit date: 2015-11-02 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
5B0K	Structure of MoeN5-Sso7d fusion protein in complex with beta-decyl maltoside Descriptor: DECYL-BETA-D-MALTOPYRANOSIDE, MoeN5,DNA-binding protein 7d Authors: Ko, T.-P, Zhang, L, Chen, C.-C, Guo, R.-T. Deposit date: 2015-10-30 Release date: 2016-03-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew.Chem.Int.Ed.Engl., 55, 2016
4CJ1	Crystal structure of CelD in complex with affitin H3 Descriptor: CALCIUM ION, ENDOGLUCANASE D, GLYCEROL, ... Authors: Correa, A, Pacheco, S, Mechaly, A.E, Obal, G, Behar, G, Mouratou, B, Oppezzo, P, Alzari, P.M, Pecorari, F. Deposit date: 2013-12-18 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One, 9, 2014
4CJ2	Crystal structure of HEWL in complex with affitin H4 Descriptor: AFFITIN H4, GLYCEROL, LYSOZYME C Authors: Correa, A, Pacheco, S, Mechaly, A.E, Obal, G, Behar, G, Mouratou, B, Oppezzo, P, Alzari, P.M, Pecorari, F. Deposit date: 2013-12-18 Release date: 2014-05-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One, 9, 2014
2XIW	Crystal structure of the Sac7d-derived IgG1-binder C3-C24S Descriptor: CHLORIDE ION, DNA-BINDING PROTEIN 7D, SULFATE ION Authors: Bellinzoni, M, Colinet, S, Behar, G, Alzari, P.M, Pecorari, F. Deposit date: 2010-07-01 Release date: 2011-07-13 Last modified: 2013-04-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Tolerance of the Archaeal Sac7D Scaffold Protein to Alternative Library Designs: Characterization of Anti-Immunoglobulin G Affitins. Protein Eng.Des.Sel., 26, 2013
2CVR	NMR solution structure of sso7d mutant, K12L, 12 conformers Descriptor: DNA-binding protein 7a Authors: Arosio, I, Recca, T, Consonni, R, Alberti, E, Fusi, P, Zetta, L. Deposit date: 2005-06-13 Release date: 2006-08-29 Last modified: 2021-11-10 Method: SOLUTION NMR Cite: Structural Determinants Responsible for the Thermostability of Sso7d and its Single Point Mutants To be Published

 

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