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8FAO
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BU of 8fao by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound
Descriptor: (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION
Authors:Grundy, M.K, Walker, M.E, Redinbo, M.R.
Deposit date:2022-11-28
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8EWT
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BU of 8ewt by Molmil
Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe
Descriptor: (5R)-5-{(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-[(prop-2-yn-1-yl)oxy]hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl}-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2022-10-24
Release date:2023-11-15
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ESG
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BU of 8esg by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound
Descriptor: (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2022-10-14
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ESI
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BU of 8esi by Molmil
Bile Salt Hydrolase from B. longum with covalent inhibitor bound
Descriptor: (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Conjugated bile acid hydrolase
Authors:Walker, M.E, Lim, L, Redinbo, M.R.
Deposit date:2022-10-14
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETE
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BU of 8ete by Molmil
Bile Salt Hydrolase from B. longum with covalent inhibitor bound
Descriptor: (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Conjugated bile acid hydrolase
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2022-10-17
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETK
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BU of 8etk by Molmil
Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe
Descriptor: (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-(2-{2-[(prop-2-yn-1-yl)oxy]ethoxy}ethoxy)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION
Authors:Walker, M.E, Grundy, M.K, Redinbo, M.R.
Deposit date:2022-10-17
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETF
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BU of 8etf by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound
Descriptor: (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2022-10-17
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8BLT
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BU of 8blt by Molmil
Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with taurocholate (TCA)
Descriptor: Bile salt hydrolase, TAUROCHOLIC ACID
Authors:Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G.
Deposit date:2022-11-10
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
8BLS
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BU of 8bls by Molmil
Structure of Lactobacillus salivarius (Ls) bile salt hydrolase(BSH) in complex with Glycocholate (GCA)
Descriptor: Bile salt hydrolase, GLYCOCHOLIC ACID
Authors:Karlov, D.S, Long, S.L, Zeng, X, Xu, F, Lal, K, Cao, L, Hayoun, K, Lin, J, Joyce, S.A, Tikhonova, I.G.
Deposit date:2022-11-10
Release date:2023-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses.
Structure, 31, 2023
7SVG
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BU of 7svg by Molmil
Bile Salt Hydrolase A from Lactobacillus gasseri with chenodeoxycholate and taurine bound
Descriptor: 2-AMINOETHANESULFONIC ACID, CHENODEOXYCHOLIC ACID, Choloylglycine hydrolase
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
7SVF
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BU of 7svf by Molmil
Bile salt hydrolase A from Lactobacillus gasseri with taurine bound
Descriptor: 2-AMINOETHANESULFONIC ACID, Choloylglycine hydrolase, POTASSIUM ION
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
7SVH
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BU of 7svh by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri
Descriptor: Choloylglycine hydrolase, MAGNESIUM ION
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
7SVK
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BU of 7svk by Molmil
Bile Salt Hydrolase from Lactobacillus reuteri
Descriptor: Choloylglycine hydrolase, SULFATE ION
Authors:Walker, M.E, Beaty, V.V, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
7SVE
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BU of 7sve by Molmil
Bile Salt Hydrolase A from Lactobacillus acidophilus
Descriptor: Choloylglycine hydrolase
Authors:Walker, M.E, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
7SVJ
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BU of 7svj by Molmil
Bile Salt Hydrolase from Lactobacillus ingluviei
Descriptor: CALCIUM ION, Choloylglycine hydrolase, DI(HYDROXYETHYL)ETHER, ...
Authors:Walker, M.E, Patel, S, Redinbo, M.R.
Deposit date:2021-11-19
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Nat Microbiol, 8, 2023
6UFY
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BU of 6ufy by Molmil
B. theta Bile Salt Hydrolase
Descriptor: Choloylglycine hydrolase
Authors:Seegar, T.C.M.
Deposit date:2019-09-25
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Development of a covalent inhibitor of gut bacterial bile salt hydrolases.
Nat.Chem.Biol., 16, 2020
6UH4
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BU of 6uh4 by Molmil
B. theta Bile Salt Hydrolase with covalent inhibitor
Descriptor: (5R,6R)-6-[(1S,2R,4aS,4bS,7R,8aS,10R,10aS)-7,10-dihydroxy-1,2,4b-trimethyltetradecahydrophenanthren-2-yl]-5-methylheptan-2-one, Choloylglycine hydrolase
Authors:Seegar, T.C.M.
Deposit date:2019-09-26
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Development of a covalent inhibitor of gut bacterial bile salt hydrolases.
Nat.Chem.Biol., 16, 2020
6MHM
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BU of 6mhm by Molmil
Crystal structure of human acid ceramidase in covalent complex with carmofur
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dementiev, A, Joachimiak, A, Doan, N.
Deposit date:2018-09-18
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.743 Å)
Cite:Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
J. Med. Chem., 62, 2019
6DXX
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BU of 6dxx by Molmil
Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent benzothiazole-piperazine inhibitor ARN19702, in presence of Triton X-100
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DY0
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BU of 6dy0 by Molmil
Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) covalently bound to beta-lactam inhibitor ARN726, in presence of Triton X-100
Descriptor: (2S)-3-amino-2-{[(4-cyclohexylbutoxy)carbonyl]amino}propanethioic S-acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.014 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DXZ
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BU of 6dxz by Molmil
Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent benzothiazole-piperazine inhibitor ARN19702, in presence of Triton X-100
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL, 4-(2,4,4-trimethylpentan-2-yl)phenol, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DXY
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BU of 6dxy by Molmil
Murine N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DY1
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BU of 6dy1 by Molmil
Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) with fatty acid (myristate), in presence of Triton X-100
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL, CHLORIDE ION, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DXW
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BU of 6dxw by Molmil
Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DY3
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BU of 6dy3 by Molmil
Caenorhabditis elegans N-acylethanolamine-hydrolyzing acid amidase (NAAA) ortholog
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, N-acylethanolamine-hydrolyzing acid amidase alpha-subunit, N-acylethanolamine-hydrolyzing acid amidase beta-subunit
Authors:Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B.
Deposit date:2018-07-01
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

 

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