4NPD
 
 | | High-resolution structure of C domain of staphylococcal protein A at cryogenic temperature | | Descriptor: | Immunoglobulin G-binding protein A, THIOCYANATE ION, ZINC ION | | Authors: | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | | Deposit date: | 2013-11-21 | | Release date: | 2014-10-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (0.9 Å) | | Cite: | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.
Structure, 22, 2014
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8DA5
 | | Coevolved affibody-Z domain pair LL1.c4 | | Descriptor: | GLYCEROL, Immunoglobulin G-binding protein A, affibody LL1.FIVM | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA7
 | | Coevolved affibody-Z domain pair LL1.c6 | | Descriptor: | Immunoglobulin G-binding protein A, MALONATE ION, affibody LL1.FIFV | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA3
 | | Coevolved affibody-Z domain pair LL1.c1 | | Descriptor: | Affibody LL1.FILF, Immunoglobulin G-binding protein A, MALONATE ION, ... | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DAB
 | | Coevolved affibody-Z domain pair LL2.c17 | | Descriptor: | Affibody LL2.IVVY, Immunoglobulin G-binding protein A | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.134 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DAC
 | | Coevolved affibody-Z domain pair LL2.c22 | | Descriptor: | Affibody LL2.FILV, GLYCEROL, Immunoglobulin G-binding protein A | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA8
 | | Coevolved affibody-Z domain pair LL2.c1 | | Descriptor: | Affibody LL2.FIIK, GLYCEROL, Immunoglobulin G-binding protein A | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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8DA9
 | | Coevolved affibody-Z domain pair LL2.c3 | | Descriptor: | Affibody LL2.FIIV, GLYCEROL, Immunoglobulin G-binding protein A, ... | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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4NPE
 | | High-resolution structure of C domain of staphylococcal protein A at room temperature | | Descriptor: | Immunoglobulin G-binding protein A, THIOCYANATE ION, ZINC ION | | Authors: | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | | Deposit date: | 2013-11-21 | | Release date: | 2014-10-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.
Structure, 22, 2014
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4NPF
 | | High-resolution structure of two tandem B domains of staphylococcal protein A connected by the conserved linker | | Descriptor: | Immunoglobulin G-binding protein A | | Authors: | Deis, L.N, Pemble IV, C.W, Oas, T.G, Richardson, J.S, Richardson, D.C. | | Deposit date: | 2013-11-21 | | Release date: | 2014-10-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity.
Structure, 22, 2014
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8DA6
 | | Coevolved affibody-Z domain pair LL1.c5 | | Descriptor: | Affibody LL1.FIIM, Immunoglobulin G-binding protein A | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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6K65
 | | Application of anti-helix antibodies in protein structure determination (9014-1P4B) | | Descriptor: | 1P4B variable heavy chain, 1P4B variable light chain, Immunoglobulin G-binding protein A | | Authors: | Lee, J.O, Jin, M.S, Kim, J.W, Kim, S, Lee, H, Cho, G.Y. | | Deposit date: | 2019-06-01 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Application of antihelix antibodies in protein structure determination.
Proc.Natl.Acad.Sci.USA, 116, 2019
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5U6A
 | | CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-PEG3-MEDITOPE | | Descriptor: | Heavy Chain, Immunoglobulin G binding protein A, Light Chain, ... | | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | | Deposit date: | 2016-12-07 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.736 Å) | | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-PEG3-Meditope
To Be Published
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8DAA
 | | Coevolved affibody-Z domain pair LL2.c7 | | Descriptor: | Affibody LL2.FIVK, Immunoglobulin G-binding protein A, MALONATE ION | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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5U3D
 | | STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT | | Descriptor: | Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, MEMAB TRASTUZUMAB FAB LIGHT CHAIN I83E, ... | | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | Deposit date: | 2016-12-01 | | Release date: | 2018-03-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Meditope Enabled Trastuzumab I83E Variant
To Be Published
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6K3M
 | | Application of anti-helix antibodies in protein structure determination (8189-3LRH) | | Descriptor: | 3LRH intrabody, SpA IgG-binding domain protein,Protein A | | Authors: | Lee, J.O, Jin, M.S, Kim, J.W, Kim, S, Lee, H, Cho, G.Y. | | Deposit date: | 2019-05-20 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Application of antihelix antibodies in protein structure determination.
Proc.Natl.Acad.Sci.USA, 116, 2019
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5U5F
 | | MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK | | Descriptor: | 5-DIPHENYL LONG MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, ... | | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | Deposit date: | 2016-12-06 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Meditope Enabled Trastuzumab I83E Variant In Complex With (Ac)Cqfda(Ph)2Strrlrcggsk
To Be Published
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6B9Z
 | | Trastuzumab Fab v3 | | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain, ... | | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | | Deposit date: | 2017-10-11 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.
Bioconjug. Chem., 29, 2018
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4ZMD
 | | C domain of staphylococcal protein A mutant - Q9W | | Descriptor: | Immunoglobulin G-binding protein A | | Authors: | Deis, L.N, Oas, T.G. | | Deposit date: | 2015-05-03 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Suppression of conformational heterogeneity at a protein-protein interface.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5U5M
 | | CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE | | Descriptor: | AZIDO-PEG4-MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB, ... | | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | | Deposit date: | 2016-12-06 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-Meditope
To Be Published
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6BAH
 | | Trastuzumab Fab v3 with 5-diphenyl meditope variant | | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain,IGH@ protein, ... | | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | | Deposit date: | 2017-10-12 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.
Bioconjug. Chem., 29, 2018
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8DA4
 | | Coevolved affibody-Z domain pair LL1.c2 | | Descriptor: | Affibody LL1.FIVM, Immunoglobulin G-binding protein A, SULFATE ION, ... | | Authors: | Jude, K.M, Yang, A, Garcia, K.C. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science, 381, 2023
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6K64
 | | Application of anti-helix antibodies in protein structure determination (8188-3LRH) | | Descriptor: | 3LRH intrabody, Protein A | | Authors: | Lee, J.O, Jin, M.S, Kim, J.W, Kim, S, Lee, H, Cho, G.Y. | | Deposit date: | 2019-06-01 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.933 Å) | | Cite: | Application of antihelix antibodies in protein structure determination.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6K6A
 | | Application of anti-helix antibodies in protein structure determination (8188cys-3LRHcys) | | Descriptor: | 3LRH intrabody, Engineered Protein A | | Authors: | Lee, J.O, Jin, M.S, Kim, J.W, Kim, S, Lee, H, Cho, G.Y. | | Deposit date: | 2019-06-02 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Application of antihelix antibodies in protein structure determination.
Proc.Natl.Acad.Sci.USA, 116, 2019
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4IOI
 | | Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC | | Descriptor: | Immunoglobulin G-binding protein A, Protein L, Trastuzumab heavy chain, ... | | Authors: | Bzymek, K.P, Zer, C, Avery, K.N, Williams, J.C. | | Deposit date: | 2013-01-07 | | Release date: | 2013-10-09 | | Last modified: | 2013-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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