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8TEO
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Shaker in low K+ (4mM K+)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-07-06
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse.
Sci Adv, 9, 2023
8F1D
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BU of 8f1d by Molmil
Voltage-gated potassium channel Kv3.1 apo
Descriptor: CHOLESTEROL, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1, ...
Authors:Chen, Y, Ishchenko, A.
Deposit date:2022-11-04
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1C
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BU of 8f1c by Molmil
Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one, POTASSIUM ION, ...
Authors:Chen, Y, Ishchenko, A.
Deposit date:2022-11-04
Release date:2023-10-25
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc.Natl.Acad.Sci.USA, 120, 2023
8U7Z
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BU of 8u7z by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(CTD)/Gbeta1gamma2
Descriptor: BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8U80
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KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD)
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8U83
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KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.975 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8U84
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KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8U82
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KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8U81
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BU of 8u81 by Molmil
KCTD5/Cullin3/Gbeta1gamma2 Complex: State A From Composite RELION Multi-body Refinement Map
Descriptor: BTB/POZ domain-containing protein KCTD5, Cullin-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Kuntz, D.A, Nguyen, D.M, Narayanan, N, Prive, G.G.
Deposit date:2023-09-15
Release date:2023-10-11
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structure and dynamics of a pentameric KCTD5/Cullin3/G beta gamma E3 ubiquitin ligase complex
Biorxiv, 2023
8SD3
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BU of 8sd3 by Molmil
CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-06
Release date:2023-09-27
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
8SDA
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BU of 8sda by Molmil
CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-06
Release date:2023-09-27
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
8I79
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BU of 8i79 by Molmil
Cryo-EM structure of KCTD7 in complex with Cullin3
Descriptor: BTB/POZ domain-containing protein KCTD7, Cullin-3
Authors:Jiang, W, Wang, W, Zheng, S.
Deposit date:2023-01-31
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
8JKB
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BU of 8jkb by Molmil
Cryo-EM structure of KCTD5 in complex with Gbeta gamma subunits
Descriptor: BTB/POZ domain-containing protein KCTD5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Authors:Zheng, S, Jiang, W, Wang, W, Kong, Y.
Deposit date:2023-06-01
Release date:2023-07-26
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
7W6T
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BU of 7w6t by Molmil
CryoEM structure of human KChIP1-Kv4.3-DPP6 complex
Descriptor: Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1
Authors:Ma, D.M, Guo, J.T.
Deposit date:2021-12-02
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
7W6N
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BU of 7w6n by Molmil
CryoEM structure of human KChIP1-Kv4.3 complex
Descriptor: Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1
Authors:Ma, D.M, Guo, J.T.
Deposit date:2021-12-02
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
7W6S
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BU of 7w6s by Molmil
CryoEM structure of human KChIP2-Kv4.3 complex
Descriptor: Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2
Authors:Ma, D.M, Guo, J.T.
Deposit date:2021-12-02
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
7W3Y
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BU of 7w3y by Molmil
CryoEM structure of human Kv4.3
Descriptor: Isoform 2 of Potassium voltage-gated channel subfamily D member 3
Authors:Ma, D.M, Guo, J.T.
Deposit date:2021-11-26
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.
Cell Res., 32, 2022
7PQT
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BU of 7pqt by Molmil
Apo human Kv3.1 cryo-EM structure
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1
Authors:Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W.
Deposit date:2021-09-20
Release date:2022-08-17
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Pnas Nexus, 1, 2022
7PQU
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BU of 7pqu by Molmil
Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563)
Descriptor: 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl)pyrrole-3-carboxamide, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1
Authors:Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W.
Deposit date:2021-09-20
Release date:2022-08-17
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Pnas Nexus, 1, 2022
8DFL
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BU of 8dfl by Molmil
Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation)
Descriptor: Nanobody A0194009G09, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3,Green fluorescent protein fusion
Authors:Meyerson, J.R, Selvakumar, P.
Deposit date:2022-06-22
Release date:2022-07-13
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nat Commun, 13, 2022
7UKF
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BU of 7ukf by Molmil
Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region
Descriptor: MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKH
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BU of 7ukh by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region
Descriptor: CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ...
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.33 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7UKG
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BU of 7ukg by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
Descriptor: Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.24 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
7SSZ
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BU of 7ssz by Molmil
Structure of human Kv1.3 with A0194009G09 nanobodies
Descriptor: Nanobody A0194009G09, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3,Green fluorescent protein fusion
Authors:Meyerson, J.R, Selvakumar, P.
Deposit date:2021-11-11
Release date:2022-06-29
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Nat Commun, 13, 2022
7SSY
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BU of 7ssy by Molmil
Structure of human Kv1.3 (alternate conformation)
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3,Green fluorescent protein fusion
Authors:Meyerson, J.R, Selvakumar, P.
Deposit date:2021-11-11
Release date:2022-06-29
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.
Nat Commun, 13, 2022

 

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