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8D1B
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BU of 8d1b by Molmil
CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin
Descriptor: Pikachurin, Probable G-protein coupled receptor 179
Authors:Patil, D.N, Martemyanov, K.A.
Deposit date:2022-05-27
Release date:2023-07-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
7ZC9
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BU of 7zc9 by Molmil
Human Pikachurin/EGFLAM C-terminal Laminin-G domain (LG3)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Pikachurin, SULFATE ION
Authors:Pantalone, S, Forneris, F.
Deposit date:2022-03-26
Release date:2023-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
7CEC
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BU of 7cec by Molmil
Structure of alpha6beta1 integrin in complex with laminin-511
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Arimori, T, Miyazaki, N, Takagi, J.
Deposit date:2020-06-22
Release date:2021-06-23
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of laminin recognition by integrin.
Nat Commun, 12, 2021
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
Authors:Chen, P, Jin, R.
Deposit date:2021-04-27
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
6PNP
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BU of 6pnp by Molmil
Crystal structure of the splice insert-free neurexin-1 LNS2 domain in complex with neurexophilin-1
Descriptor: Neurexin-1, Neurexophilin-1
Authors:Wilson, S.C, White, K.I, Zhou, Q, Brunger, A.T.
Deposit date:2019-07-02
Release date:2019-10-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing.
Embo J., 38, 2019
6PNQ
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BU of 6pnq by Molmil
Crystal structure of the SS2A splice insert-containing neurexin-1 LNS2 domain in complex with neurexophilin-1
Descriptor: Neurexin-1, Neurexophilin-1
Authors:Wilson, S.C, White, K.I, Zhou, Q, Brunger, A.T.
Deposit date:2019-07-02
Release date:2019-10-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.947 Å)
Cite:Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing.
Embo J., 38, 2019
5Z8Y
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BU of 5z8y by Molmil
Crystal structure of human LRRTM2 in complex with Neurexin 1beta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Yamagata, A, Fukai, S.
Deposit date:2018-02-01
Release date:2018-10-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Nat Commun, 9, 2018
6CW1
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BU of 6cw1 by Molmil
Crystal structure of Neurexin-1 alpha ectodomain fragment, L2-L3
Descriptor: Neurexin-1
Authors:Misra, A, Rudenko, G.
Deposit date:2018-03-29
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structural Plasticity of Neurexin 1 alpha : Implications for its Role as Synaptic Organizer.
J. Mol. Biol., 430, 2018
5XAU
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BU of 5xau by Molmil
Crystal structure of integrin binding fragment of laminin-511
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Takizawa, M, Arimori, T, Kitago, Y, Takagi, J, Sekiguchi, K.
Deposit date:2017-03-15
Release date:2017-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanistic basis for the recognition of laminin-511 by alpha 6 beta 1 integrin.
Sci Adv, 3, 2017
5VXZ
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BU of 5vxz by Molmil
High-affinity AXL decoy receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Mathrews, I.I, Kapur, S, Kariolis, M.S, Cochran, J.R.
Deposit date:2017-05-24
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
J. Clin. Invest., 127, 2017
5IK4
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BU of 5ik4 by Molmil
Laminin A2LG45 C-form, Apo.
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Briggs, D.C, Hohenester, E, Campbell, K.P.
Deposit date:2016-03-03
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
5IK7
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BU of 5ik7 by Molmil
Laminin A2LG45 I-form, Apo.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Briggs, D.C, Hohenester, E, Campbell, K.P.
Deposit date:2016-03-03
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
5IK5
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BU of 5ik5 by Molmil
Laminin A2LG45 C-form, G6/7 bound.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-hydroxy-4-methyl-2H-chromen-2-one, CALCIUM ION, ...
Authors:Briggs, D.C, Hohenester, E, Campbell, K.P.
Deposit date:2016-03-03
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
5IK8
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BU of 5ik8 by Molmil
Laminin A2LG45 I-form, G6/7 bound.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-hydroxy-4-methyl-2H-chromen-2-one, ...
Authors:Briggs, D.C, Hohenester, E, Campbell, K.P.
Deposit date:2016-03-03
Release date:2016-08-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
4RA0
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BU of 4ra0 by Molmil
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Kariolis, M.S, Kapur, S, Mathews, I.I, Cochran, J.R.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Nat.Chem.Biol., 10, 2014
3VKF
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BU of 3vkf by Molmil
Crystal Structure of Neurexin 1beta/Neuroligin 1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurexin-1-beta, ...
Authors:Tanaka, H, Miyazaki, N, Nogi, T, Iwasaki, K, Takagi, J.
Deposit date:2011-11-15
Release date:2012-08-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin.
Cell Rep, 2, 2012
3SH4
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BU of 3sh4 by Molmil
Laminin G like domain 3 from human perlecan
Descriptor: LG3 peptide
Authors:Van Le, B, Kim, K.K.
Deposit date:2011-06-15
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.
J.Mol.Biol., 414, 2011
3SH5
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BU of 3sh5 by Molmil
Calcium-bound Laminin G like domain 3 from human perlecan
Descriptor: CALCIUM ION, LG3 peptide
Authors:Van Le, B, Kim, K.K.
Deposit date:2011-06-16
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.
J.Mol.Biol., 414, 2011
3R05
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BU of 3r05 by Molmil
Structure of neurexin 1 alpha (domains LNS1-LNS6), with splice insert SS3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neurexin-1-alpha
Authors:Venugopal, V, Rudenko, G.
Deposit date:2011-03-07
Release date:2011-06-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The structure of neurexin 1α reveals features promoting a role as synaptic organizer
Structure, 19, 2011
3QCW
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BU of 3qcw by Molmil
Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neurexin-1-alpha
Authors:Rudenko, G.
Deposit date:2011-01-17
Release date:2011-06-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structure of Neurexin 1 alpha Reveals Features Promoting a Role as Synaptic Organizer
Structure, 19, 2011
3POY
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BU of 3poy by Molmil
Crystal Structure of the alpha-Neurexin-1 ectodomain, LNS 2-6
Descriptor: Neurexin-1-alpha, beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Miller, M.T, Mileni, M, Comoletti, D, Stevens, R.C, Harel, M, Taylor, P.
Deposit date:2010-11-23
Release date:2011-06-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function.
Structure, 19, 2011
3ASI
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BU of 3asi by Molmil
Alpha-Neurexin-1 ectodomain fragment; LNS5-EGF3-LNS6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurexin-1-alpha
Authors:Tanaka, H, Nogi, T, Yasui, N, Takagi, J.
Deposit date:2010-12-13
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Variant-Specific Neuroligin-Binding by alpha-Neurexin
Plos One, 6, 2011
3MW4
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BU of 3mw4 by Molmil
Crystal structure of beta-neurexin 3 without the splice insert 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurexin-2-beta, ...
Authors:Jin, X, Shapiro, L.
Deposit date:2010-05-05
Release date:2010-07-28
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Splice Form Dependence of beta-Neurexin/Neuroligin Binding Interactions.
Neuron, 67, 2010
3MW3
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BU of 3mw3 by Molmil
Crystal structure of beta-neurexin 2 with the splice insert 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurexin-2-beta
Authors:Jin, X, Shapiro, L.
Deposit date:2010-05-05
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Splice Form Dependence of beta-Neurexin/Neuroligin Binding Interactions.
Neuron, 67, 2010
3MW2
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BU of 3mw2 by Molmil
Crystal structure of beta-neurexin 1 with the splice insert 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Neurexin-1-alpha, PHOSPHATE ION
Authors:Jin, X, Shapiro, L.
Deposit date:2010-05-05
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Splice Form Dependence of beta-Neurexin/Neuroligin Binding Interactions.
Neuron, 67, 2010

 

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