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1RV1
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BU of 1rv1 by Molmil
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor: CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE, Ubiquitin-protein ligase E3 Mdm2
Authors:Lukacs, C, Kammlott, U, Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
1T4E
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Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor
Descriptor: (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID, Ubiquitin-protein ligase E3 Mdm2
Authors:Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1T4F
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Structure of human MDM2 in complex with an optimized p53 peptide
Descriptor: SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, optimized p53 peptide
Authors:Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1TTV
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BU of 1ttv by Molmil
NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
Descriptor: 1-{[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]CARBONYL}PIPERAZINE, Ubiquitin-protein ligase E3 Mdm2
Authors:Fry, D.C, Emerson, S.D, Palme, S, Vu, B.T, Liu, C.M, Podlaski, F.
Deposit date:2004-06-23
Release date:2005-01-04
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:NMR structure of a complex between MDM2 and a small molecule inhibitor.
J.Biomol.Nmr, 30, 2004
1UHR
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BU of 1uhr by Molmil
Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
Descriptor: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1
Authors:Yamada, K, Saito, K, Nameki, N, Inoue, M, Koshiba, S, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Matsuda, T, Seki, E, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-07-09
Release date:2004-08-24
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
To be Published
1V31
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BU of 1v31 by Molmil
Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
Descriptor: hypothetical protein RAFL11-05-P19
Authors:Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-21
Release date:2004-04-21
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
To be Published
1V32
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Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
Descriptor: hypothetical protein RAFL09-47-K03
Authors:Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-24
Release date:2004-04-24
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
To be Published
1YCQ
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BU of 1ycq by Molmil
XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
Descriptor: MDM2, P53
Authors:Kussie, P.H, Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1YCR
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MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53
Descriptor: MDM2, P53
Authors:Kussie, P.H, Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1Z1M
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BU of 1z1m by Molmil
NMR structure of unliganded MDM2
Descriptor: Ubiquitin-protein ligase E3 Mdm2
Authors:Uhrinova, S, Uhrin, D, Powers, H, Watt, K, Zheleva, D, Fischer, P, McInnes, C, Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2AXI
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HDM2 in complex with a beta-hairpin
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ...
Authors:Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
2GV2
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BU of 2gv2 by Molmil
MDM2 in complex with an 8-mer p53 peptide analogue
Descriptor: 8-MER P53 PEPTIDE ANALOGUE, E3 ubiquitin-protein ligase Mdm2
Authors:Schubert, C, Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
2LZG
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BU of 2lzg by Molmil
NMR Structure of Mdm2 (6-125) with Pip-1
Descriptor: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid
Authors:Michelsen, K.B, Jordan, J.B, Lewis, J, Long, A.M, Yang, E, Rew, Y, Zhou, J, Yakowec, P, Schnier, P.D, Huang, X, Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Method:SOLUTION NMR
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
2M86
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Solution structure of Hdm2 with engineered cyclotide
Descriptor: E3 ubiquitin-protein ligase Mdm2, MCo-PMI
Authors:Majumder, S, Ji, Y, Millard, M, Borra, R, Bi, T, Elnagar, A.Y, Neamati, N, Camarero, J.A.
Deposit date:2013-05-07
Release date:2013-07-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide.
J.Am.Chem.Soc., 135, 2013
2MPS
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BU of 2mps by Molmil
Structure of complex of MDM2(3-109) and P73 TAD(10-25)
Descriptor: E3 ubiquitin-protein ligase Mdm2, Tumor protein p73
Authors:Shin, J.S, Ha, J.H, Chi, S.W.
Deposit date:2014-06-02
Release date:2015-06-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
Cell Cycle, 14, 2015
2RUH
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BU of 2ruh by Molmil
Chemical Shift Assignments for MIP and MDM2 in bound state
Descriptor: E3 ubiquitin-protein ligase Mdm2
Authors:Nagata, T, Shirakawa, K, Kobayashi, N, Shiheido, H, Horisawa, K, Katahira, M, Doi, N, Yanagawa, H.
Deposit date:2014-06-03
Release date:2014-10-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display
Plos One, 9, 2014
2Z5S
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BU of 2z5s by Molmil
Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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BU of 2z5t by Molmil
Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3DAC
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BU of 3dac by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
3EQS
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BU of 3eqs by Molmil
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3G03
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BU of 3g03 by Molmil
Structure of human MDM2 in complex with high affinity peptide
Descriptor: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
3IUX
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BU of 3iux by Molmil
Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)
Descriptor: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
Authors:Pazgier, M, Lu, W.
Deposit date:2009-08-31
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angew.Chem.Int.Ed.Engl., 48, 2009
3IWY
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BU of 3iwy by Molmil
Crystal structure of human MDM2 complexed with D-peptide (12 residues)
Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
Authors:Pazgier, M, Lu, W.
Deposit date:2009-09-03
Release date:2010-04-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3JZK
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crystal structure of MDM2 with chromenotriazolopyrimidine 1
Descriptor: (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2
Authors:Huang, X.
Deposit date:2009-09-23
Release date:2009-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
J.Med.Chem., 52, 2009
3JZR
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Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W)
Descriptor: E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer)
Authors:Schonbrunn, E, Phan, J.
Deposit date:2009-09-24
Release date:2009-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285, 2010

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