1C1Y
  • Download 1c1y
  • View 1c1y
Molmil generated image of 1c1y
CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).
Descriptor:RAS-RELATED PROTEIN RAP-1A, PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE RAF-1, MAGNESIUM ION, ...
Authors:Nassar, N.
Deposit date:1999-07-22
Release date:1999-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature, 375, 1995
3KUC
  • Download 3kuc
  • View 3kuc
Molmil generated image of 3kuc
COMPLEX OF RAP1A(E30D/K31E)GDP WITH RAFRBD(A85K/N71R)
Descriptor:Ras-related protein Rap-1A, RAF proto-oncogene serine/threonine-protein kinase, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Filchtinski, D., Sharabi, O., Rueppel, A., Vetter, I.R., Herrmann, C., Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
3NY5
  • Download 3ny5
  • View 3ny5
Molmil generated image of 3ny5
CRYSTAL STRUCTURE OF THE RBD DOMAIN OF SERINE/THREONINE-PROTEIN KINASE B-RAF FROM HOMO SAPIENS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4694F
Descriptor:Serine/threonine-protein kinase B-raf
Authors:Vorobiev, S., Su, M., Seetharaman, J., Patel, P., Xiao, R., Ciccosanti, C., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-07-14
Release date:2010-07-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Crystal structure of the RBD domain of serine/threonine-protein kinase B-raf from Homo sapiens.
To be Published
1GUA
  • Download 1gua
  • View 1gua
Molmil generated image of 1gua
HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131
Descriptor:RAP1A, C-RAF1, MAGNESIUM ION, ...
Authors:Nassar, N., Wittinghofer, A.
Deposit date:1996-06-18
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ras/Rap effector specificity determined by charge reversal.
Nat.Struct.Biol., 3, 1996
3KUD
  • Download 3kud
  • View 3kud
Molmil generated image of 3kud
COMPLEX OF RAS-GDP WITH RAFRBD(A85K)
Descriptor:GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Filchtinski, D., Sharabi, O., Rueppel, A., Vetter, I.R., Herrmann, C., Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
4G0N
  • Download 4g0n
  • View 4g0n
Molmil generated image of 4g0n
CRYSTAL STRUCTURE OF WT H-RAS-GPPNHP BOUND TO THE RBD OF RAF KINASE
Descriptor:GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Fetics, S.K., Kearney, B.M., Buhrman, G., Mattos, C.
Deposit date:2012-07-09
Release date:2013-07-17
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
4G3X
  • Download 4g3x
  • View 4g3x
Molmil generated image of 4g3x
CRYSTAL STRUCTURE OF Q61L H-RAS-GPPNHP BOUND TO THE RBD OF RAF KINASE
Descriptor:GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Fetics, S.K., Kearney, B.M., Buhrman, G., Mattos, C.
Deposit date:2012-07-15
Release date:2013-07-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
1RFA
  • Download 1rfa
  • View 1rfa
Molmil generated image of 1rfa
NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1
Descriptor:RAF1
Authors:Emerson, S.D., Madison, V.S., Palermo, R.E., Waugh, D.S., Scheffler, J.E., Tsao, K.-L., Kiefer, S.E., Liu, S.P., Fry, D.C.
Deposit date:1995-04-26
Release date:1996-06-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface.
Biochemistry, 34, 1995
1RRB
  • Download 1rrb
  • View 1rrb
Molmil generated image of 1rrb
THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Descriptor:RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
Authors:Terada, T., Ito, Y., Shirouzu, M., Tateno, M., Hashimoto, K., Kigawa, T., Ebisuzaki, T., Takio, K., Shibata, T., Yokoyama, S., Smith, B.O., Laue, E.D., Cooper, J.A., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-03-26
Release date:1999-03-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins.
J.Mol.Biol., 286, 1999
1WFY
  • Download 1wfy
  • View 1wfy
Molmil generated image of 1wfy
SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF MOUSE RGS14
Descriptor:regulator of G-protein signaling 14; rap1/rap2 interacting protein
Authors:Nakanishi, T., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-27
Release date:2004-11-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Ras-binding domain of mouse RGS14
To be Published
1WXM
  • Download 1wxm
  • View 1wxm
Molmil generated image of 1wxm
SOLUTION STRUCTURE OF THE N-TERMINAL RAS-BINDING DOMAIN (RBD) IN HUMAN A-RAF KINASE
Descriptor:A-Raf proto-oncogene serine/threonine-protein kinase
Authors:Zhao, C., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-01-26
Release date:2005-07-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the N-terminal Ras-binding Domain (RBD) in Human a-Raf Kinase
To be Published
2L05
  • Download 2l05
  • View 2l05
Molmil generated image of 2l05
SOLUTION NMR STRUCTURE OF THE RAS-BINDING DOMAIN OF SERINE/THREONINE-PROTEIN KINASE B-RAF FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4694F
Descriptor:Serine/threonine-protein kinase B-raf
Authors:Aramini, J.M., Janjua, H., Ciccosanti, C., Shastry, R., Huang, Y.J., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of the Ras-binding domain of Serine/threonine-protein kinase B-raf from Homo sapiens, Northeast Structural Genomics Consortium Target HR4694F
To be Published
2MSE
  • Download 2mse
  • View 2mse
Molmil generated image of 2mse
NMR DATA-DRIVEN MODEL OF GTPASE KRAS-GNP:ARAFRBD COMPLEX TETHERED TO A LIPID-BILAYER NANODISC
Descriptor:Apolipoprotein A-I, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b, ...
Authors:Mazhab-Jafari, M., Stathopoulos, P., Marshall, C., Ikura, M.
Deposit date:2014-07-29
Release date:2015-06-03
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Proc.Natl.Acad.Sci.USA, 112, 2015
5J17
  • Download 5j17
  • View 5j17
Molmil generated image of 5j17
SOLUTION STRUCTURE OF RAS BINDING DOMAIN (RBD) OF B-RAF
Descriptor:Serine/threonine-protein kinase B-raf
Authors:Dutta, K., Vasquez-Del Carpio, R., Aggarwal, A.K., Reddy, E.P.
Deposit date:2016-03-29
Release date:2016-10-05
Last modified:2017-09-20
Method:SOLUTION NMR
Cite:A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell, 165, 2016
5J18
  • Download 5j18
  • View 5j18
Molmil generated image of 5j18
SOLUTION STRUCTURE OF RAS BINDING DOMAIN (RBD) OF B-RAF COMPLEXED WITH RIGOSERTIB (COMPLEX I)
Descriptor:Serine/threonine-protein kinase B-raf, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine
Authors:Dutta, K., Vasquez-Del Carpio, R., Aggarwal, A.K., Reddy, E.P.
Deposit date:2016-03-29
Release date:2016-05-04
Method:SOLUTION NMR
Cite:A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell, 165, 2016
5J2R
  • Download 5j2r
  • View 5j2r
Molmil generated image of 5j2r
SOLUTION STRUCTURE OF RAS BINDING DOMAIN (RBD) OF B-RAF
Descriptor:Serine/threonine-protein kinase B-raf, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine
Authors:Dutta, K., Vasquez-Del Carpio, R., Aggarwal, A.K., Reddy, E.P.
Deposit date:2016-03-29
Release date:2016-05-04
Method:SOLUTION NMR
Cite:A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell, 165, 2016
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan