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1ZBO
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BU of 1zbo by Molmil
X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
Descriptor: hypothetical protein BPP1347
Authors:Forouhar, F, Yong, W, Conover, K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2005-04-08
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Hypothetical Protein BPP1347 from Bordetella parapertussis, Northeast Structural Genomics Target BoR27.
To be Published
2ANE
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BU of 2ane by Molmil
Crystal structure of N-terminal domain of E.Coli Lon Protease
Descriptor: ATP-dependent protease La
Authors:Li, M, Rasulova, F, Melnikov, E.E, Rotanova, T.V, Gustchina, A, Maurizi, M.R, Wlodawer, A.
Deposit date:2005-08-11
Release date:2005-11-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of the N-terminal domain of E. coli Lon protease.
Protein Sci., 14, 2005
3LJC
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BU of 3ljc by Molmil
Crystal structure of Lon N-terminal domain.
Descriptor: ATP-dependent protease La
Authors:Li, M, Gustchina, A, Dauter, Z, Wlodawer, A.
Deposit date:2010-01-26
Release date:2010-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the N-terminal fragment of Escherichia coli Lon protease
Acta Crystallogr.,Sect.D, 66, 2010
3M65
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BU of 3m65 by Molmil
Crystal structure of Bacillus subtilis Lon N-terminal domain
Descriptor: ATP-dependent protease La 1
Authors:Duman, R.E, Lowe, J.Y.
Deposit date:2010-03-15
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of Bacillus subtilis Lon Protease.
J.Mol.Biol., 401, 2010
4CI3
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BU of 4ci3 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI1
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BU of 4ci1 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI2
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BU of 4ci2 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4TZ4
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BU of 4tz4 by Molmil
Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ...
Authors:Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M.
Deposit date:2014-07-09
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
5FQD
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BU of 5fqd by Molmil
Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase
Descriptor: CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ...
Authors:Petzold, G, Fischer, E.S, Thoma, N.H.
Deposit date:2015-12-09
Release date:2016-02-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase.
Nature, 532, 2016
5HXB
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BU of 5hxb by Molmil
Cereblon in complex with DDB1, CC-885, and GSPT1
Descriptor: 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
Authors:Chamberlain, P.P, Matyskiela, M, Pagarigan, B.
Deposit date:2016-01-30
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
5V3O
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BU of 5v3o by Molmil
Cereblon in complex with DDB1 and CC-220
Descriptor: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Matyskiela, M, Pagarigan, B, Chamberlain, P.
Deposit date:2017-03-07
Release date:2017-05-03
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem., 61, 2018
6BN9
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BU of 6bn9 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.382 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BNB
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BU of 6bnb by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (6.343 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BN7
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BU of 6bn7 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC.
Descriptor: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BOY
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BU of 6boy by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC.
Descriptor: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ...
Authors:Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
Deposit date:2017-11-21
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6H0F
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BU of 6h0f by Molmil
Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)
Descriptor: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ...
Authors:Petzold, G, Bunker, R.D, Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6H0G
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BU of 6h0g by Molmil
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
Descriptor: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Bunker, R.D, Petzold, G, Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6IHG
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BU of 6ihg by Molmil
N terminal domain of Mycobacterium avium complex Lon protease
Descriptor: Lon protease
Authors:Chen, X.Y, Zhang, S.J, Bi, F.K, Guo, C.Y, Yao, H.W, Lin, D.H.
Deposit date:2018-09-29
Release date:2019-08-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.
Protein Sci., 28, 2019
6U5Z
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BU of 6u5z by Molmil
Cryo-EM structure of E. coli LonA S679A
Descriptor: Lon protease
Authors:Botos, I, Lountos, G.T, Weimin, W, Wlodawer, A.
Deposit date:2019-08-28
Release date:2020-02-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery
Curr Res Struct Biol, 1, 2020
6UML
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BU of 6uml by Molmil
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P.
Deposit date:2019-10-09
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Nat.Struct.Mol.Biol., 27, 2020
6WQH
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BU of 6wqh by Molmil
Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ...
Authors:Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C.
Deposit date:2020-04-28
Release date:2021-06-09
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease.
J.Biol.Chem., 297, 2021
7CAY
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BU of 7cay by Molmil
Crystal Structure of Lon N-terminal domain protein from Xanthomonas campestris
Descriptor: ATP-dependent protease
Authors:Singh, R, Sharma, B, Deshmukh, S, Kumar, A, Makde, R.D.
Deposit date:2020-06-10
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of XCC3289 from Xanthomonas campestris: homology with the N-terminal substrate-binding domain of Lon peptidase.
Acta Crystallogr.,Sect.F, 76, 2020
6XK9
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BU of 6xk9 by Molmil
Cereblon in complex with DDB1, CC-90009, and GSPT1
Descriptor: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
Authors:Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P.
Deposit date:2020-06-25
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood, 137, 2021
7CR9
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BU of 7cr9 by Molmil
Crystal structure of the N-terminal fragment (residue 1-206) of LonA protease from Meiothermus taiwanensis
Descriptor: Lon protease
Authors:Lin, C.-C, Chang, C.-I.
Deposit date:2020-08-12
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease.
Elife, 10, 2021
7CRA
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BU of 7cra by Molmil
Crystal structure of the N-terminal fragment (residue 1-291) of LonA protease from Meiothermus taiwanensis
Descriptor: Lon protease, SULFATE ION
Authors:Lin, C.-C, Chang, C.-I.
Deposit date:2020-08-13
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease.
Elife, 10, 2021

 

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