1ZBO
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X-RAY CRYSTAL STRUCTURE OF PROTEIN BPP1347 FROM BORDETELLA PARAPERTUSSIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET BOR27.
Descriptor:hypothetical protein BPP1347
Authors:Forouhar, F., Yong, W., Conover, K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2005-04-08
Release date:2005-04-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Hypothetical Protein BPP1347 from Bordetella parapertussis, Northeast Structural Genomics Target BoR27.
To be Published
3LJC
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CRYSTAL STRUCTURE OF LON N-TERMINAL DOMAIN.
Descriptor:ATP-dependent protease La
Authors:Li, M., Gustchina, A., Dauter, Z., Wlodawer, A.
Deposit date:2010-01-26
Release date:2010-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the N-terminal fragment of Escherichia coli Lon protease
Acta Crystallogr.,Sect.D, 66, 2010
3M65
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS LON N-TERMINAL DOMAIN
Descriptor:ATP-dependent protease La 1
Authors:Duman, R.E., Lowe, J.Y.
Deposit date:2010-03-15
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of Bacillus subtilis Lon Protease.
J.Mol.Biol., 401, 2010
4CI1
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STRUCTURE OF THE DDB1-CRBN E3 UBIQUITIN LIGASE BOUND TO THALIDOMIDE
Descriptor:DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ...
Authors:Fischer, E.S., Boehm, K., Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI2
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STRUCTURE OF THE DDB1-CRBN E3 UBIQUITIN LIGASE BOUND TO LENALIDOMIDE
Descriptor:DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ...
Authors:Fischer, E.S., Boehm, K., Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI3
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STRUCTURE OF THE DDB1-CRBN E3 UBIQUITIN LIGASE BOUND TO POMALIDOMIDE
Descriptor:DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ...
Authors:Fischer, E.S., Boehm, K., Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4TZ4
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CRYSTAL STRUCTURE OF HUMAN CEREBLON IN COMPLEX WITH DDB1 AND LENALIDOMIDE
Descriptor:DNA damage-binding protein 1, Protein cereblon, ZINC ION, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B., Riley, M.
Deposit date:2014-07-09
Release date:2014-08-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
5FQD
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STRUCTURAL BASIS OF LENALIDOMIDE INDUCED CK1A DEGRADATION BY THE CRL4CRBN UBIQUITIN LIGASE
Descriptor:DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, CASEIN KINASE I ISOFORM ALPHA, ...
Authors:Petzold, G., Fischer, E.S., Thoma, N.H.
Deposit date:2015-12-09
Release date:2016-02-24
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase.
Nature, 532, 2016
5HXB
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CEREBLON IN COMPLEX WITH DDB1, CC-885, AND GSPT1
Descriptor:Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Chamberlain, P.P., Matyskiela, M., Pagarigan, B.
Deposit date:2016-01-30
Release date:2016-06-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
5V3O
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CEREBLON IN COMPLEX WITH DDB1 AND CC-220
Descriptor:DNA damage-binding protein 1, Protein cereblon, (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, ...
Authors:Matyskiela, M., Pagarigan, B., Chamberlain, P.
Deposit date:2017-03-07
Release date:2017-05-03
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem., 61, 2018
6BN7
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CRYSTAL STRUCTURE OF DDB1-CRBN-BRD4(BD1) COMPLEX BOUND TO DBET23 PROTAC.
Descriptor:DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ...
Authors:Nowak, R.P., DeAngelo, S.L., Buckley, D., Bradner, J.E., Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BN8
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CRYSTAL STRUCTURE OF DDB1-CRBN-BRD4(BD1) COMPLEX BOUND TO DBET55 PROTAC.
Descriptor:DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ...
Authors:Nowak, R.P., DeAngelo, S.L., Buckley, D., Bradner, J.E., Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-06-06
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.990035 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BN9
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CRYSTAL STRUCTURE OF DDB1-CRBN-BRD4(BD1) COMPLEX BOUND TO DBET70 PROTAC
Descriptor:DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ...
Authors:Nowak, R.P., DeAngelo, S.L., Buckley, D., Bradner, J.E., Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (4.382 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BNB
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CRYSTAL STRUCTURE OF DDB1-CRBN-BRD4(BD1) COMPLEX BOUND TO DBET57 PROTAC
Descriptor:DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ...
Authors:Nowak, R.P., DeAngelo, S.L., Buckley, D., Ishoey, M., He, Z., Zhang, T., Bradner, J.E., Fischer, E.S.
Deposit date:2017-11-16
Release date:2018-05-30
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (6.343 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6BOY
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CRYSTAL STRUCTURE OF DDB1-CRBN-BRD4(BD1) COMPLEX BOUND TO DBET6 PROTAC.
Descriptor:DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ...
Authors:Nowak, R.P., DeAngelo, S.L., Buckley, D., Bradner, J.E., Fischer, E.S.
Deposit date:2017-11-21
Release date:2018-05-30
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6H0F
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STRUCTURE OF DDB1-CRBN-POMALIDOMIDE COMPLEX BOUND TO IKZF1(ZF2)
Descriptor:DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Ikaros (IKZF1), ...
Authors:Petzold, G., Bunker, R.D., Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6H0G
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STRUCTURE OF THE DDB1-CRBN-POMALIDOMIDE COMPLEX BOUND TO ZNF692(ZF4)
Descriptor:DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Zinc finger protein 692, ...
Authors:Bunker, R.D., Petzold, G., Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (4.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
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