3FDE
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MOUSE UHRF1 SRA DOMAIN BOUND WITH HEMI-METHYLATED CPG DNA, CRYSTAL STRUCTURE IN SPACE GROUP C222(1) AT 1.4 A RESOLUTION
Descriptor:E3 ubiquitin-protein ligase UHRF1, 5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', ...
Authors:Hashimoto, H., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2008-11-25
Release date:2009-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
2ZKD
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF MOUSE NP95 IN COMPLEX WITH HEMI-METHYLATED CPG DNA
Descriptor:DNA (5'-D(*DCP*DTP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DAP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DAP*DG)-3'), E3 ubiquitin-protein ligase UHRF1, ...
Authors:Arita, K., Ariyoshi, M., Tochio, H., Nakamura, Y., Shirakawa, M.
Deposit date:2008-03-19
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
Nature, 455, 2008
3BI7
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF E3 UBIQUITIN-PROTEIN LIGASE UHRF1
Descriptor:E3 ubiquitin-protein ligase UHRF1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
2ZKG
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CRYSTAL STRUCTURE OF UNLIGANDED SRA DOMAIN OF MOUSE NP95
Descriptor:E3 ubiquitin-protein ligase UHRF1, 1,2-ETHANEDIOL
Authors:Arita, K., Ariyoshi, M., Tochio, H., Nakamura, Y., Shirakawa, M.
Deposit date:2008-03-19
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
Nature, 455, 2008
2PB7
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF THE HUMAN UHRF1 PROTEIN
Descriptor:E3 ubiquitin-protein ligase UHRF1
Authors:Delagoutte, B., Birck, C., Samama, J.P.
Deposit date:2007-03-28
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mammalian SRA domain is a new nucleosome binding motif
To be Published
6A5K
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 1
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
Authors:Li, X., Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3DWH
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF SRA DOMAIN
Descriptor:E3 ubiquitin-protein ligase UHRF1, SULFATE ION, GLYCEROL
Authors:Qian, C., Jakoncic, J., Zhou, M.
Deposit date:2008-07-22
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1.
J.Biol.Chem., 283, 2008
2ZO1
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MOUSE NP95 SRA DOMAIN DNA SPECIFIC COMPLEX 2
Descriptor:DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), E3 ubiquitin-protein ligase UHRF1, ...
Authors:Hashimoto, H., Horton, J.R., Cheng, X.
Deposit date:2008-05-05
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
3F8J
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MOUSE UHRF1 SRA DOMAIN BOUND WITH HEMI-METHYLATED CPG, CRYSTAL STRUCTURE IN SPACE GROUP C222(1)
Descriptor:E3 ubiquitin-protein ligase UHRF1, 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', ...
Authors:Hashimoto, H., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2008-11-12
Release date:2009-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
4QEO
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CRYSTAL STRUCTURE OF KRYPTONITE IN COMPLEX WITH MCHH DNA, H3(1-15) PEPTIDE AND SAH
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4, DNA 5'-GGTACT(5CM)ATCAGTAT-3', ...
Authors:Du, J., Li, S., Patel, D.J.
Deposit date:2014-05-17
Release date:2014-07-30
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE.
Mol.Cell, 55, 2014
4PW7
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STRUCTURE OF UHRF2-SRA IN COMPLEX WITH A 5MC-CONTAINING DNA
Descriptor:E3 ubiquitin-protein ligase UHRF2, 5mC-containing DNA1, 5mC-containing DNA2
Authors:ZHou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu, R.M.
Deposit date:2014-03-19
Release date:2014-05-07
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
4QEN
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CRYSTAL STRUCTURE OF KRYPTONITE IN COMPLEX WITH MCHH DNA AND SAH
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4, DNA (5'-D(*GP*GP*TP*AP*CP*TP*(5CM)P*AP*TP*CP*AP*GP*TP*AP*T)-3'), ...
Authors:Du, J., Li, S., Patel, D.J.
Deposit date:2014-05-17
Release date:2014-07-30
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE.
Mol.Cell, 55, 2014
2ZO0
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MOUSE NP95 SRA DOMAIN DNA SPECIFIC COMPLEX 1
Descriptor:E3 ubiquitin-protein ligase UHRF1, DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3')
Authors:Hashimoto, H., Horton, J.R., Cheng, X.
Deposit date:2008-05-05
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
3CLZ
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THE SET AND RING ASSOCIATED (SRA) DOMAIN OF UHRF1 BOUND TO METHYLATED DNA
Descriptor:E3 ubiquitin-protein ligase UHRF1, 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3', 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3'
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Dong, A., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-03-20
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature, 455, 2008
3Q0B
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CRYSTAL STRUCTURE OF SUVH5 SRA- FULLY METHYLATED CG DNA COMPLEX IN SPACE GROUP P42212
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5, DNA (5'-D(*AP*CP*TP*AP*(5CM)P*GP*TP*AP*GP*T)-3')
Authors:Eerappa, R., Simanshu, D.K., Patel, D.J.
Deposit date:2010-12-15
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.
Genes Dev., 25, 2011
4PW5
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STRUCTURE OF UHRF2-SRA IN COMPLEX WITH A 5HMC-CONTAINING DNA, COMPLEX I
Descriptor:E3 ubiquitin-protein ligase UHRF2, 5hmC-containing DNA1, 5hmC-containing DNA2
Authors:ZHou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu, R.M.
Deposit date:2014-03-18
Release date:2014-05-07
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
Mol.Cell, 54, 2014
3F8I
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MOUSE UHRF1 SRA DOMAIN BOUND WITH HEMI-METHYLATED CPG, CRYSTAL STRUCTURE IN SPACE GROUP P21
Descriptor:E3 ubiquitin-protein ligase UHRF1, 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3'
Authors:Hashimoto, H., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2008-11-12
Release date:2009-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
3OLN
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF E3 UBIQUITIN-PROTEIN LIGASE UHRF2
Descriptor:E3 ubiquitin-protein ligase UHRF2
Authors:Walker, J.R., Xue, S., Avvakumov, G.V., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-08-26
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Set and Ring Associated (SRA) domain of human ubiquitin-like containing PHD and RING finger domains 2 (UHRF2)
To be Published
6A5M
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 2
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
Authors:Li, X., Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3Q0D
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CRYSTAL STRUCTURE OF SUVH5 SRA- HEMI METHYLATED CG DNA COMPLEX
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5, DNA (5'-D(*TP*CP*CP*AP*(5CM)P*GP*TP*CP*AP*G)-3'), ...
Authors:Eerappa, R., Simanshu, D.K., Patel, D.J.
Deposit date:2010-12-15
Release date:2011-02-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3704 Å)
Cite:A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.
Genes Dev., 25, 2011
4NJ5
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CRYSTAL STRUCTURE OF SUVH9
Descriptor:Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9, ZINC ION
Authors:Du, J., Patel, D.J.
Deposit date:2013-11-08
Release date:2014-01-22
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.
Nature, 507, 2014
6A5N
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH METHYLATED DNA
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, DNA (5'-D(*GP*AP*GP*TP*AP*CP*TP*(5CM)P*AP*GP*CP*AP*GP*T)-3'), ...
Authors:Li, X., Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2ZKF
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF MOUSE NP95 IN COMPLEX WITH HEMI-METHYLATED CPG DNA
Descriptor:E3 ubiquitin-protein ligase UHRF1, DNA (5'-D(P*DCP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DAP*DGP*DA)-3'), DNA (5'-D(*DCP*DTP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DGP*DA)-3')
Authors:Arita, K., Ariyoshi, M., Tochio, H., Nakamura, Y., Shirakawa, M.
Deposit date:2008-03-19
Release date:2008-09-09
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
Nature, 455, 2008
2ZKE
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CRYSTAL STRUCTURE OF THE SRA DOMAIN OF MOUSE NP95 IN COMPLEX WITH HEMI-METHYLATED CPG DNA
Descriptor:E3 ubiquitin-protein ligase UHRF1, DNA (5'-D(*DCP*DTP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DAP*DAP*DTP*DCP*(5CM)P*DGP*DGP*DTP*DAP*DG)-3')
Authors:Arita, K., Ariyoshi, M., Tochio, H., Nakamura, Y., Shirakawa, M.
Deposit date:2008-03-19
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
Nature, 455, 2008
4YGI
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CRYSTAL STRUCTURE OF SUVH5 SRA BOUND TO FULLY HYDROXYMETHYLATED CG DNA
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5, Polydeoxyribonucleotide, ...
Authors:Rajakumara, E.
Deposit date:2015-02-26
Release date:2016-02-17
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain
Sci Rep, 6, 2016
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