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8XP5	The Crystal Structure of p53/BCL-xL fusion complex from Biortus. Descriptor: Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION Authors: Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. Deposit date: 2024-01-03 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: The Crystal Structure of p53/BCL-xL fusion complex from Biortus. To Be Published
8WLS	Bcl-xL in complex with HBx BH3 delta C peptide Descriptor: Bcl-2-like protein 1, Protein X Authors: Kobayashi, N, Nagata, T, Kusunoki, H. Deposit date: 2023-10-01 Release date: 2024-03-20 Method: SOLUTION NMR Cite: Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-x L. Biochemistry, 63, 2024
8U27	Bcl-2-xL complexed with compound 35 Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate Authors: Rizo, J, Pan, Y.-Z. Deposit date: 2023-09-05 Release date: 2023-09-13 Last modified: 2023-11-08 Method: SOLUTION NMR Cite: Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Commun Biol, 6, 2023
8IQL	Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins Descriptor: Apoptosis regulator Bcl-2, Bcl-2-modifying factor Authors: Wang, H, Guo, M, Wei, H, Chen, Y. Deposit date: 2023-03-16 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (2.9577 Å) Cite: Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins. Comput Struct Biotechnol J, 21, 2023
8IQK	Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins Descriptor: Bcl-2-like protein 1, Bcl-2-modifying factor Authors: Wang, H, Guo, M, Wei, H, Chen, Y. Deposit date: 2023-03-16 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (2.879 Å) Cite: Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins. Comput Struct Biotechnol J, 21, 2023
8HLN	Crystal structure of p53/BCL2 fusion complex(complex3) Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION Authors: Guo, M, Wei, H, Wang, H, Chen, Y. Deposit date: 2022-11-30 Release date: 2023-07-26 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLL	Crystal structure of p53/BCL2 fusion complex (complex 1) Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION Authors: Wei, H, Guo, M, Wang, H, Chen, Y. Deposit date: 2022-11-30 Release date: 2023-07-26 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLM	Crystal structure of p53/BCL2 fusion complex (complex 2) Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION Authors: Guo, M, Wang, H, Wei, H, Chen, Y. Deposit date: 2022-11-30 Release date: 2023-07-26 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.522 Å) Cite: Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
7YB7	anti-apoptotic protein BCL-2-M12 Descriptor: Apoptosis regulator Bcl-2,Bcl-2-like protein 1, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide, cp2 peptide Authors: Li, F.W, Liu, C, Wu, D.L. Deposit date: 2022-06-29 Release date: 2023-11-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7YAA	Crystal structure analysis of cp3 bound BCLxl Descriptor: Bcl-2-like protein 1, GLYCEROL, N-(2-acetamidoethyl)-4-(4-methanoyl-1,3-thiazol-2-yl)benzamide, ... Authors: Li, F.W, Liu, C, Wu, C.L, Wu, D.L. Deposit date: 2022-06-27 Release date: 2023-11-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7YA5	Crystal structure analysis of cp1 bound BCL2/G101V Descriptor: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide Authors: Li, F.W, Liu, C, Wu, C.L, Wu, D.L. Deposit date: 2022-06-27 Release date: 2023-11-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7Y99	Crystal Structure Analysis of cp2 bound BCLxl Descriptor: Bcl-2-like protein 1, CP2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide Authors: Li, F.W, Liu, C, Wu, C.L, Wu, D.L. Deposit date: 2022-06-24 Release date: 2023-09-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7Y90	Crystal Structure Analysis of cp1 bound BCL2 Descriptor: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide Authors: Li, F.W. Deposit date: 2022-06-24 Release date: 2023-11-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7Y8D	Crystal structure of cp1 bound BCLxl Descriptor: (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Bcl-2-like protein 1, cp1 peptide Authors: Li, F.W, Liu, C, Wu, C.L, Wu, D.L. Deposit date: 2022-06-23 Release date: 2023-11-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
7XGF	Crystal structure of BCL-xL in complex with computationally designed inhibitor protein Descriptor: BCL-xL, BCL-xL and MCL-1 dual inhibitor 2 Authors: Oh, B.-H, Kim, S. Deposit date: 2022-04-04 Release date: 2022-07-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Comput Struct Biotechnol J, 20, 2022
7XGG	Crystal structure of BCL-xL in complex with computationally designed inhibitor protein Descriptor: BCL-xL and MCL-1 dual inhibitor, Bcl-2-like protein 1 Authors: Oh, B.-H, Kim, S. Deposit date: 2022-04-04 Release date: 2022-07-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Comput Struct Biotechnol J, 20, 2022
7WJH	Crystal structure of Bcl-xL bound to the BH3 domain of human Pxt1 Descriptor: Bcl-2-like protein 1, MAGNESIUM ION, Peroxisomal testis-specific protein 1, ... Authors: Lim, D, Ku, B. Deposit date: 2022-01-06 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1. Biochem.Biophys.Res.Commun., 625, 2022
7LHB	Crystal structure of Bcl-2 in complex with prodrug ABBV-167 Descriptor: Apoptosis regulator Bcl-2, Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester Authors: Judge, R.A, Salem, A.H. Deposit date: 2021-01-21 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.068 Å) Cite: Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol.Cancer Ther., 20, 2021
7LH7	Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor Descriptor: Bcl-2-like protein 1, N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide Authors: Judge, R.A, Tao, Z. Deposit date: 2021-01-21 Release date: 2021-06-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.409 Å) Cite: Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor ACS Medicinal Chemistry Letters, 12, 2021
7JGV	CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2 Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 Authors: Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. Deposit date: 2020-07-19 Release date: 2021-02-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
7JGW	Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1 Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 Authors: Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. Deposit date: 2020-07-19 Release date: 2021-02-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
6ZHC	PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL Descriptor: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... Authors: Chung, C. Deposit date: 2020-06-22 Release date: 2020-08-05 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
7CA4	The Crystal Structure of human Bcl-2-like protein 1 from Biortus Descriptor: Bcl-2-like protein 1, SULFATE ION Authors: Wang, F, Lv, Z, Lin, D, Huang, Y. Deposit date: 2020-06-08 Release date: 2020-07-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The Crystal Structure of human Bcl-2-like protein 1 from Biortus. To Be Published
6YLI	Crystal structure of human bcl-xL bound to trichoplax adhaerens trBak BH3 Descriptor: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1, SULFATE ION Authors: D Sa, J, Banjara, S, Kvansakul, M. Deposit date: 2020-04-07 Release date: 2021-03-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis. Sci Adv, 6, 2020
6VWC	Crystal structure of Bcl-xL in complex with tetrahydroisoquinoline-pyridine based inhibitors Descriptor: 6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}-3-{1-[(pyridin-4-yl)methyl]-1H-pyrazol-4-yl}pyridine-2-carboxylic acid, Bcl-2-like protein 1 Authors: Judge, R.A, Judd, A.S. Deposit date: 2020-02-19 Release date: 2020-10-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.604 Å) Cite: Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X L Inhibitor. Acs Med.Chem.Lett., 11, 2020

 

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